A5016090338- Mesenchymal stem cell research
- Hair Growth and Disorders
- RNA Research and Splicing
- RNA regulation and disease
- Cell Adhesion Molecules Research
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- RNA modifications and cancer
- Blood properties and coagulation
- Cancer and Skin Lesions
- Reconstructive Facial Surgery Techniques
- Ear and Head Tumors
- Wnt/β-catenin signaling in development and cancer
- Tissue Engineering and Regenerative Medicine
- Hematopoietic Stem Cell Transplantation
Jiamusi University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Peking Union Medical College Hospital
2019-2023
Plastic Surgery Hospital
2023
Academy of Military Medical Sciences
2015
Abstract Stem cell therapy has emerged as a new strategy for treatment of ischemic heart disease. Although umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have been used preferentially in the acute ischemia model, data chronic model are lacking. In this study, we investigated effect UC-MSCs originated from Wharton's jelly myocardial porcine induced by ameroid constrictor. Four weeks after constrictor placement, surviving animals were divided randomly into two groups to undergo...
Pursuing compounds capable of stimulating hair follicle growth or regeneration presents a significant challenge in dermatological research. Dermal papilla (DP) cells, which serve as dynamic niche for stem are often used to identify growth-promoting agents screening model. Here, we integrated human scalp single-cell RNA sequencing data with DP cells (hDPCs) gene expression profiles develop panel assessing inductive potential, then applied high-throughput sequencing-based (HTS2) method...
Abstract The advent of mesenchymal stem cell (MSC)-based therapies has been an exciting innovation for the treatment degenerative and inflammatory diseases. However, surface markers that accurately reflect self-renewal differentiation potential MSCs their sensitivity to environmental cues remain poorly defined. Here, we studied role CD49f in bone marrow (BMSCs) mechanism by which it regulates behavior BMSCs under conditions. We found is preferentially expressed fetal cells rather than adult...
Abstract The molecular mechanism underlying white adipogenesis in humans has not been fully elucidated beyond the transcriptional level. Here, we found that RNA-binding protein NOVA1 is required for adipogenic differentiation of human mesenchymal stem cells. By thoroughly exploring interactions between and its binding RNA, proved deficiency resulted aberrant splicing DNAJC10 with an in-frame premature stop codon, reduced expression at level hyperactivation unfolded response (UPR). Moreover,...
Neural crest-derived cells play essential roles in skin function and homeostasis. However, how they interact with environmental cues differentiate into functional remains unclear. Using a combination of single-cell data analysis, neural crest lineage tracing, flow cytometry, we found that the expression integrin α6 (ITGA6) its derivatives was developmentally regulated ITGA6 could serve as surface marker for distinguishing skin. Based on ITGA6, Wnt1-Cre be categorized three subpopulations,...
Abstract The human auricle has a complex structure, and microtia is congenital malformation characterized by decreased size loss of elaborate structure in the affected ear with high incidence. Our previous studies suggest that inadequate cell migration primary cytological basis for pathogenesis microtia, however, underlying mechanism unclear. Here, we further demonstrate chondrocytes show directional persistence during migration. Directional can define leading edge associated oriented...