A5101803359- Probiotics and Fermented Foods
- Biofuel production and bioconversion
- Microbial Metabolites in Food Biotechnology
- Microbial Metabolic Engineering and Bioproduction
- Protein Hydrolysis and Bioactive Peptides
- Telomeres, Telomerase, and Senescence
- Mitochondrial Function and Pathology
- Meat and Animal Product Quality
- Medicinal Plants and Bioactive Compounds
- Plant-based Medicinal Research
- Anaerobic Digestion and Biogas Production
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Effects of Environmental Stressors on Livestock
- Food Quality and Safety Studies
- Cardiac Arrhythmias and Treatments
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Catalysis for Biomass Conversion
- Endoplasmic Reticulum Stress and Disease
- Animal Behavior and Welfare Studies
- Fungal Biology and Applications
- Cardiovascular Function and Risk Factors
- Food composition and properties
- Thermoregulation and physiological responses
Chinese PLA General Hospital
2020-2025
Chinese People's Liberation Army
2021
PLA Academy of Military Science
2020-2021
Academy of Military Medical Sciences
2016
Enshi Tujia and Miao Autonomous Prefecture Academy of Agricultural Sciences
2015
MEI Research (United States)
2010
Washington State University
1996-2009
University of North Dakota
2007
Dalian University of Technology
1998
Abstract Stem cell therapy has emerged as a new strategy for treatment of ischemic heart disease. Although umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have been used preferentially in the acute ischemia model, data chronic model are lacking. In this study, we investigated effect UC-MSCs originated from Wharton's jelly myocardial porcine induced by ameroid constrictor. Four weeks after constrictor placement, surviving animals were divided randomly into two groups to undergo...
Heat stress (HS) threatens the worldwide dairy industry by decreasing animal production performance and health. Holstein cows buffaloes are most important animals, but their differences in metabolic mechanism of thermotolerance remain elusive. In this study, we used serum metabolomics to evaluate between crossbred under chronic heat thermal-neutral conditions. response HS, body temperatures respiratory rates were increased more for than (38.78 vs 38.24 °C, p < 0.001; 43.6 32.5 breaths/min,...
Objective: Radiotherapy is an essential method for treating cancerous tumors, and the resultant radiation-induced heart disease (RIHD) has emerged as leading non-cancerous cause of mortality among cancer survivors. However, mechanisms RIHD are still unknown, specific biomarkers effective treatment methods needing to be found. Methods: Fourteen male C57BL/6J mice, each 8 weeks old, were randomly assigned into two groups: experimental group (n = 7) a control 7). The test underwent irradiation...
The predictive value of the neutrophil-to-lymphocyte ratio (NLR) for immune checkpoint inhibitors (ICIs) in various tumors remains uncertain despite its use forecasting effectiveness immunotherapy. purpose our research was to determine prognostic significance NLR inhibitor-related myocarditis non-small-cell lung cancer (NSCLC) patients. We enrolled and monitored patients with NSCLC who received ICI therapy at Fifth Medical Center Chinese PLA General Hospital between January 1, 2018, February...
The incidence of atrial fibrillation (AF) increases with age, and telomere length gradually shortens age. However, whether is related to AF still inconclusive, the exact mechanism by which aging causes increased unclear. We hypothesize that correlated aging‐related mitochondrial dysfunction plays a role in this. This research recruited 96 elderly male patients who were admitted Second Medical Center Chinese PLA General Hospital from April October 2018. After matching age gender, non‐AF...
Background: Non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) are major health burdens, with emerging evidence suggesting NAFLD as a significant risk factor for AF, but the mechanism is remain unclear. Methods: In this study, we analyzed gene expression data from (GSE89632) AF (GSE75092) datasets Gene Expression Omnibus. We identified co-upregulated co-downregulated genes between assessed diagnostic potential of specific genes, conducted immune infiltration analysis,...
Telomeres, essential DNA-protein complexes located at chromosome ends, play a critical role in preventing fusion, recombination, and degradation, thus ensuring genomic stability. When telomeres reach limiting shortened length, they will activate DNA damage checkpoints, stop cell division trigger replicative senescence. Telomerase is composed of RNA protein, which can synthesize repeat sequences, elongate telomeres. Studies have shown that telomere length (TL) telomerase activity are closely...
Obesity is an independent risk factor for atrial fibrillation (AF). However, the mechanisms underlying this crosstalk are still being uncovered. Co-differentially expressed genes (co-DEGs) of AF and obesity microarrays were identified by bioinformatics analysis. Subsequently, functional enrichment, cell-type protein-protein interaction network analyses co-DEGs carried out. Then, we validated hub qRT-PCR patients' blood samples. Finally, CIBERSORT was utilized to evaluate microarray determine...
Background: Telomere shortening is strongly associated with cardiovascular aging and disease, patients shorter telomeres in peripheral blood leukocytes are at higher risk of diseases such as heart failure atrial fibrillation (AF). Telomerase reverse transcriptase (TERT) maintains telomere length, overexpression TERT has been shown to reduce cardiomyocyte apoptosis myocardial infarct size, extend the lifespan aged mice. However, specific impact on electrophysiology cardiomyocytes remains be...
Atrial fibrillation (AF) relapse following radiofrequency catheter ablation (RFCA) for persistent atrial (PeAF) continues to be a concern. This study establishes connection between left appendage peak flow velocity (LAAV) and recurrence of AF in individuals having PeAF first RFCA.We retrospectively studied 164 successive patients who had RFCA January 2018 December 2019. Before the ablation, LAAV was recorded using transesophageal echocardiography (TEE). The demographic clinical data were...