A5021818780- Cardiovascular Health and Disease Prevention
- Birth, Development, and Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Antioxidant Activity and Oxidative Stress
- Electrochemical Analysis and Applications
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Ultrasound Imaging and Elastography
- MicroRNA in disease regulation
- Advanced Wireless Communication Technologies
- Genetics, Aging, and Longevity in Model Organisms
- Ion channel regulation and function
- Spaceflight effects on biology
- Mitochondrial Function and Pathology
- Optical Imaging and Spectroscopy Techniques
- Telomeres, Telomerase, and Senescence
- Cancer-related molecular mechanisms research
- Non-Invasive Vital Sign Monitoring
- Atrial Fibrillation Management and Outcomes
- Biomarkers in Disease Mechanisms
- Optical Wireless Communication Technologies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular and exercise physiology
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
Chinese PLA General Hospital
2021-2024
Air Force Medical University
2019-2024
Chinese People's Liberation Army
2021
PLA Academy of Military Science
2020-2021
Elucidating the impacts of long-term spaceflight on cardiovascular health is urgently needed in face rapid development human space exploration. Recent reports including NASA Twins Study vascular deconditioning and aging astronauts are controversial. The aims this study were to elucidate whether microgravity promotes underlying mechanisms.
Genetic variants among individuals have been associated with ineffective control of hypertension. Previous work has shown that hypertension a polygenic nature, and interactions between these loci variations in drug response. Rapid detection multiple genetic high sensitivity specificity is needed for the effective implementation personalized medicine treatment Here, we used cationic conjugated polymer (CCP)-based multistep fluorescence resonance energy transfer (MS-FRET) technique to...
The incidence of atrial fibrillation (AF) increases with age, and telomere length gradually shortens age. However, whether is related to AF still inconclusive, the exact mechanism by which aging causes increased unclear. We hypothesize that correlated aging‐related mitochondrial dysfunction plays a role in this. This research recruited 96 elderly male patients who were admitted Second Medical Center Chinese PLA General Hospital from April October 2018. After matching age gender, non‐AF...
Objectives The objective was to utilize a smartwatch sphygmomanometer predict new-onset hypertension within short-term follow-up among individuals with high-normal blood pressure (HNBP).
There is still lack of a simple, accurate, and noninvasive method for rat aortic pulse wave velocity (PWV) measurement, especially the transit distance cannot be accurately measured. Thus, we aimed to derive an equation as function nose-to-rump length (L) test hypothesis that PWV measured by new combined with Doppler ultrasound (the "equation method") may have stronger correlation invasive measurements than traditional "body surface method." Two-hundred male Sprague-Dawley (SD) rats (age...
Some essential hypertension (EH) patients show maternal inheritance, which is the mode of mitochondrial DNA inheritance. This study examines mechanisms by mutations cause EH characterized The enrolled 115 volunteers, who were divided into maternally inherited (group A, n = 17), non-maternally B, 65), and normal control C, 33) groups. A tRNA (15910 C>T) gene mutation was significantly correlated with may play an important role in pathogenesis EH. Examining two families carrying 15910...
The validation of various risk scores in elderly patients with comorbid atrial fibrillation (AF) and acute coronary syndrome (ACS) has not been reported. present study compared the predictive performance existing these patients.A total 1252 AF ACS comorbidities (≥ 65 years old) were consecutively enrolled from January 2015 to December 2019. All followed up for one year. predicting bleeding thromboembolic events was calculated compared.During 1-year follow-up, 183 (14.6%) had events, 198...
The aim was to study the effect of Allitridum (Allicin) on heterologous expression late sodium current ΔKPQ-SCN5A mutations in HEK293 cells, with a view screening new drugs for treatment long QT syndrome type 3 (LQT3).The plasmid transiently transferred into cells by liposome technology and administered extracellular perfusion, recorded whole-cell patch-clamp technology. Application Allicin 30 μM reduced (INa,L ) Nav1.5 channel encoded from 1.92 ± 0.12 0.65 0.03 pA/pF (P < 0.01, n = 15),...
Objective: Telomeres gradually shorten and the incidence of atrial fibrillation (AF) increases with age. However, association telomere length AF is still controversial. This study aims to determine correlation between leukocyte (LTL) presence AF. Methods: recruited 96 male patients 97 healthy controls (aged ≥60 years) Anthropometric, clinical laboratory analysis were performed on all subjects. Blood LTL was detected by quantitative real-time PCR assay. PGC-1α concentration evaluated ELISA...