A5091572094- Sarcoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Protein Degradation and Inhibitors
- Ear and Head Tumors
- RNA modifications and cancer
- Tumors and Oncological Cases
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Urologic and reproductive health conditions
- MicroRNA in disease regulation
- Hedgehog Signaling Pathway Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Epigenetics and DNA Methylation
- Insect and Arachnid Ecology and Behavior
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Renal cell carcinoma treatment
- Vitamin C and Antioxidants Research
- Redox biology and oxidative stress
- Ferroptosis and cancer prognosis
- Cardiac tumors and thrombi
- Insect and Pesticide Research
- RNA Research and Splicing
Tulane University
2022-2024
National University Cancer Institute, Singapore
2022
National University of Singapore
2022
SRM Institute of Science and Technology
2020-2021
Novartis (Switzerland)
2011
National Institute of Mental Health and Neurosciences
2006
Abstract Desmoplastic small round cell tumors (DSRCT) are a type of aggressive, pediatric sarcoma characterized by the EWSR1::WT1 fusion oncogene. Targeted therapies for DSRCT have not been developed, and standard multimodal therapy is insufficient, leading to 5-year survival rate only 15% 25%. Here, we depleted in established its essentiality vivo. Transcriptomic analysis revealed that induces unique transcriptional alterations compared with WT1 other oncoproteins binding directly mediates...
Abstract Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. The refractory to treatment with a 5-year survival rate of only 15–25%, necessitating development novel therapeutics, especially those able target chemoresistant subpopulations. Novel in vitro stem cell-like (CSC-like) culture conditions increase expression stemness markers (SOX2, NANOG) and reduce DSRCT line susceptibility chemotherapy while maintaining ability...
Abstract Desmoplastic Small Round Cell Tumor (DSRCT) is a rare, pediatric cancer caused by the EWSR1::WT1 fusion protein. DSRCT predominantly occurs in males, which comprise 80-90% of patient population. While reason for this male predominance remains unknown, one hypothesis that androgen receptor (AR) plays critical role and elevated testosterone levels males help drive tumor growth. Here, we demonstrate AR highly expressed relative to other fusion-driven sarcomas antagonists enzalutamide...
Abstract Background: The addition of bevacizumab (bev) to atezolizumab (atezo) has demonstrated enhanced anti-tumor immune responses in pts with solid tumors (Wallin 2016). In IMmotion150 (NCT01984242), a phase II trial that compared atezo+/-bev vs sunitinib (sun) untreated mRCC, encouraging antitumor activity atezo+bev sun was observed PD-L1 expressing tumors. We performed integrated tumor genomic analyses correlate molecular signatures clinical outcomes. Methods: status on infiltrating...
Lens explant cultures were used to assess the mechanism of drug-induced cataractogenic potential NVS001, a peroxisome proliferator–activated receptor delta (PPARδ) agonist, which resulted in cataract all treated animals during 13-week rat study. Ciglitazone, PPARγ agonist and compound, was as positive control validate this model. Rat lenses extracted cultured medium supplemented with antibiotics for 24-h preincubation pretreatment. Lenses showing no signs damage at end pretreatment period...
Abstract Desmoplastic Small Round Cell Tumor (DSRCT) is a rare, pediatric cancer caused by the EWSR1::WT1 fusion protein. DSRCT predominantly occurs in males, which comprise 80-90% of patient population. While reason for male prevalence remains unknown, one hypothesis that androgen receptor (AR), when stimulated testosterone plays critical role tumor growth. As rare cancer, model systems including cell lines and patient-derived xenografts are scarce. Further, have been thought to seed...
Abstract Desmoplastic small round cell tumor (DSRCT) is an aggressive, pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. Targeted therapies are lacking and current standard of care, multimodal therapy, insufficient, leading to a 5-year survival rate less than 25%. While oncoprotein critical growth in vitro, its importance has yet be examined vivo. Further, set downstream targets oncogenesis mechanism which two isoforms regulate them remain underinvestigated. Here we generate...
<div>Abstract<p>Desmoplastic small round cell tumors (DSRCT) are a type of aggressive, pediatric sarcoma characterized by the EWSR1::WT1 fusion oncogene. Targeted therapies for DSRCT have not been developed, and standard multimodal therapy is insufficient, leading to 5-year survival rate only 15% 25%. Here, we depleted in established its essentiality <i>in vivo</i>. Transcriptomic analysis revealed that induces unique transcriptional alterations compared with WT1...
<p>EWSR1::WT1 Upregulated Pathways</p>
<p>Supplementary Figures and Tables</p>
<p>EWSR1::WT1 Downregulated Pathways</p>
<div>Abstract<p>Desmoplastic small round cell tumors (DSRCT) are a type of aggressive, pediatric sarcoma characterized by the EWSR1::WT1 fusion oncogene. Targeted therapies for DSRCT have not been developed, and standard multimodal therapy is insufficient, leading to 5-year survival rate only 15% 25%. Here, we depleted in established its essentiality <i>in vivo</i>. Transcriptomic analysis revealed that induces unique transcriptional alterations compared with WT1...
<p>Supplementary Figures and Tables</p>
<p>EWSR1::WT1 Downregulated Pathways</p>
<p>EWSR1::WT1 Upregulated Pathways</p>
Abstract Desmoplastic Small Round Cell Tumor (DSRCT) is a rare, pediatric cancer caused by the EWSR1::WT1 fusion protein. DSRCT predominantly occurs in males, which comprise 80-90% of patient population. While reason for this male predominance remains unknown, one hypothesis that androgen receptor (AR) plays critical role and elevated testosterone levels males help drive tumor growth. Here, we demonstrate AR highly expressed relative to other fusion-driven sarcomas antagonists enzalutamide...
Reactive oxygen species are ubiquitous in nature, and function as signalling molecules biological systems; they may also contribute to oxidative stress several pathobiological disease states. In this report, we describe a simple, reliable, sensitive, specific assay for the detection quantitation of hydrogen peroxide (H2O2) release by living cells, organoids, or tissues. Furthermore, low cost reagents required makes it inexpensive relative commercial kits. The high sensitivity specificity...