A5051709695- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Advanced biosensing and bioanalysis techniques
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- CRISPR and Genetic Engineering
- Sex work and related issues
- Vitamin D Research Studies
- Cervical Cancer and HPV Research
- Mosquito-borne diseases and control
- Adolescent Sexual and Reproductive Health
- Poxvirus research and outbreaks
- Sexuality, Behavior, and Technology
- Maternal Mental Health During Pregnancy and Postpartum
- Travel-related health issues
- COVID-19 and healthcare impacts
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Family Caregiving in Mental Illness
- Pelvic floor disorders treatments
- Medication Adherence and Compliance
- Bone and Joint Diseases
- Prenatal Substance Exposure Effects
University of Pennsylvania
2010-2024
Philadelphia VA Medical Center
2024
Drexel University
2013-2023
Institute for Molecular Medicine
2017-2019
Comenius University Bratislava
2003
Visual inspection of the cervix with application 4% acetic acid (VIA) is an inexpensive alternative to cytology-based screening in areas where resources are limited, such as many developing countries. We have examined diagnostic agreement between off-site (remote) expert diagnosis using photographs (photographic acid, PIA) and in-person VIA. The images for remote evaluation were taken a mobile phone transmitted by MMS. study population consisted 95 HIV-positive women Gaborone, Botswana. An...
The Health Belief Model has been useful for studying uptake of HIV prevention behaviors and had limited application to understanding utilization pre-exposure prophylaxis (PrEP), a biomedical strategy reduce acquisition. We recruited 90 persons undergoing screening educated them about PrEP. followed up with 35 participants approximately 3 weeks later quantitatively assessed PrEP uptake. No participant initiated conducted in-depth interviews 15 explore situational factors impacting this...
Introduction Pre-exposure prophylaxis (PrEP) is an effective tool to reduce HIV transmission. The primary objective of this study was assess awareness PrEP by individuals living with (HIV+) and acceptance its use for their negative (HIV-) partners. Methods A cross sectional survey conducted among who received care at urban clinic between January 2013 June 2013. examined knowledge, attitudes, acceptability PrEP, perception transmission risk HIV. Chi-Square test Fisher's Exact were used...
To gauge the safety and utility of extended tecovirimat/cidofovir for severe mpox, here we report our experience caring 4 patients with mpox advanced human immunodeficiency virus (HIV) at Hospitals University Pennsylvania during 2022 global outbreak. Three had recurrent courses complicated by superinfections, coinfections insufficient nutrition/housing, requiring tecovirimat (5-16 weeks) cidofovir (1-12 doses) probenecid fluids. At follow-up, undetectable HIV RNA on antiretrovirals, improved...
Metabolic complications, including type 2 diabetes mellitus and metabolic syndrome, are increasingly recognized among HIV-infected individuals. Low vitamin D levels increase the risk of mellitus, supplementation has been shown to decrease in patients without HIV infection.The primary objective was determine whether deficiency (serum 25-hyrdoxyvitamin <20 ng/ml) associated with patients. Our secondary syndrome HIV.We conducted a cross-sectional study participants enrolled prospective Modena...
Abstract The CRISPR/Cas9 system has been proposed as a cure strategy for HIV. However, few published guide RNAs (gRNAs) are predicted to cleave the majority of HIV-1 viral quasispecies (vQS) observed within and among patients. We report design novel pipeline identify gRNAs that target HIV across large number infected individuals. Next generation sequencing (NGS) LTRs from 269 HIV-1-infected samples in Drexel CARES Cohort was used select with broad-spectrum activity. In silico ,...
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9 system has been used to excise the HIV-1 proviral genome from latently infected cells, potentially offering a cure for HIV-infected patients. Recent studies have shown that most published guide RNAs (gRNAs) do not account diverse viral quasispecies within or among patients, which continue diversify with time even in long-term antiretroviral therapy (ART)-suppressed Given this observation, genomes were deep...
Background Research surrounding attitudes and intentions concerning pre-exposure prophylaxis (PrEP) among at-risk heterosexuals, women ethnic racial minorities is needed to inform programs scale this effective HIV prevention intervention these populations. Methods:The study sample includes 192 HIV-negative heterosexuals recruited from testing sites operating in high prevalence neighbourhoods a mid-Atlantic city. Participants received brief educational sessions on PrEP completed...
Background: Interventions to promote medication adherence and viral suppression are needed among HIV-positive individuals. We aimed determine the feasibility, acceptability, preliminary impact of daily financial incentives linked real-time monitoring treatment-experienced Methods: At an HIV clinic in Philadelphia, we conducted a pilot randomized trial adults with unsuppressed loads (>400 copies/mL). Participants intervention group were eligible for lottery-based rewards dependent on...
Throughout the developing world, delivery of women’s health care, specifically cervical cancer screening, is limited by cost and access to trained personnel. Visual inspection with application 4% acetic acid (VIA) a practical, inexpensive alternative cytology-based screening in areas where resources are limited. Mobile telemedicine using cellular phone photograph cervix after VIA allows clinicians “see treat” clinics capture high-quality images cervix, which can then be transmitted through...
Adoption of pre-exposure prophylaxis (PrEP) to prevent HIV infection has been slow. The purpose this study was evaluate knowledge, attitudes and referral practices for PrEP among non-prescribing providers, who may play key role.We performed a cross-sectional survey on attitudes, 66 prevention providers (1st August 31st December, 2016), in Philadelphia, followed by qualitative interviews with 12 them (5th April 10th May, 2017).Participants had mean age 36 years, 62% females. Majority were...
Existing screening tools for HIV-associated neurocognitive disorders (HAND) are often clinically impractical detecting milder forms of impairment. The formal diagnosis HAND requires an assessment both cognition and impairment in activities daily living (ADL). To address the critical need identifying patients who may have disability associated with HAND, we implemented a low-cost tool, Virtual Driving Test (VDT) platform, vulnerable cohort people HIV (PWH). VDT presents opportunity to...
Vpr is an HIV-1 accessory protein that plays numerous roles during viral replication, and some of which are cell type dependent. To test the hypothesis tropism extends beyond envelope into vpr gene, studies were performed to identify associations between coreceptor usage variation in HIV-1-infected patients. Colinear Env-V3 amino acid sequences obtained from LANL sequence database well-suppressed patients Drexel/Temple Medicine CNS AIDS Research Eradication Study (CARES) Cohort. Genotypic...
Abstract Among 146 urban heterosexuals screening negative for human immunodeficiency virus, one third anticipated increased sexual risk taking with virus preexposure prophylaxis. Men (vs. women) and black white) participants had odds anticipating decreased condom use. persons reporting transactional sex expected to increase partnerships. Risk compensation could affect reproductive health disease control.
Hepatitis C virus (HCV) infection disproportionately affects HIV-infected patients. Co-infected patients have worse prognoses than mono-infected HCV treatment with new oral direct acting antiviral (DAA) therapy is effective in HIV/HCV co-infected cure rates similar to Despite the treatments, only a small proportion of are treated for infection. This study aims describe barriers hepatitis We performed retrospective observational seen at an urban HIV clinic year 2016 Drexel University,...
Abstract Background In areas with a high prevalence of hepatitis C virus (HCV) infection, emergency department (ED) visits may provide unique opportunities for screening. The catchment area Hahnemann University Hospital (HUH) has an HCV seroprevalence rate >20%. However, limited data exist addressing testing strategies in the ED. This study describes experience piloting nurse-driven screening protocol urban hospital Methods A was developed and implemented on August 1, 2018. We performed...
Abstract Background Pre-exposure prophylaxis (PrEP) is a highly effective daily oral antiretroviral medication that was approved by the FDA in 2012 and has been shown to reduce risk of HIV 95% real-world studies. Despite this, many healthcare providers are not offering PrEP their patients who at for HIV. Methods We performed cross-sectional study among Drexel Internal Medicine, Family Obstetrics Gynecology residents. The survey included questions about experience, knowledge, attitudes toward...