A5073810947- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Orthopedic Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
- Vitamin C and Antioxidants Research
- COVID-19 and healthcare impacts
- Mycobacterium research and diagnosis
- Telemedicine and Telehealth Implementation
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Mobile Health and mHealth Applications
- Parasite Biology and Host Interactions
- Hepatitis B Virus Studies
- Economic and Financial Impacts of Cancer
- Body Image and Dysmorphia Studies
- Viral Infections and Outbreaks Research
- Therapeutic Uses of Natural Elements
- Postcolonial and Cultural Literary Studies
- Vitamin K Research Studies
- Clostridium difficile and Clostridium perfringens research
- Liver Disease and Transplantation
Thomas Jefferson University Hospital
2021-2025
Thomas Jefferson University
2021-2024
Office of Infectious Diseases
2021-2022
Drexel University
2018-2020
University of Pennsylvania
2016
Hadassah Medical Center
2007
Beth Israel Deaconess Medical Center
2007
University of New Haven
2001
BackgroundIn 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2–6 weeks after transplantation from a common donor. We describe an investigation into cause of these patients.MethodsFrom Nov 7, to Feb 24, 2022, we conducted public health involving 15 agencies and medical centres USA. tested various specimens (blood, cerebrospinal fluid, intraocular serum, tissues) donor recipients by serology, RT-PCR, immunohistochemistry, metagenomic...
Abstract Background Xylazine is a non-opioid analgesic that has become prevalent additive in the illicit drug supply due to its low cost and synergistic effect with opioids. It associated soft tissue ulcers necrotic can lead infection, amputation, death. Our hospital created novel Infectious Diseases (ID) consultation service help manage xylazine-related other infectious sequelae of substance use disorder (SUD). Herein we describe characteristics patients SUD who presented our ulcers....
Despite the widespread availability of effective vaccines, new cases infection with severe acute respiratory syndrome coronavirus-2, cause coronavirus disease 2019 (COVID-19), remain a concern in settings vaccine hesitancy and breakthrough. In this randomized, controlled, phase 2 trial, we hypothesized that high-dose ascorbic acid delivered intravenously to achieve pharmacologic concentrations may target high viral COVID-19 thus improve early clinical outcomes. Sixty-six patients admitted...
During the early months of COVID-19 pandemic, mortality associated with disease declined in United States. The standard care for pharmacological interventions evolved during this period as new and repurposed treatments were used alone combination. Though these medications have been studied individually, data are limited regarding relative impact different medication combinations. objectives study to evaluate association COVID-19-related observed combinations determine whether changes...
Abstract CD4 Th cells play critical roles in stimulating Ab production and generating primary or maintaining memory CTL. The requirement for help CTL responses has been reported to vary depending on the vector method used immunization. In this study, we examined T cell an experimental AIDS vaccine based live recombinant vesicular stomatitis virus (VSV) expressing HIV Env protein. We found that CD8 short-term VSV nucleocapsid (VSV N) proteins were largely intact cell-deficient mice. These...
Summary Background: Adherence to antiretroviral medication leads HIV suppression and decreased morbidity mortality. In resource- limited settings, the dependence on paper medical charts unstable electronic health records creates a challenge monitoring adherence. A pharmacy-based strategy that utilizes existing cellular phone infrastructure may lead more stable system monitor Objectives: To develop evaluate usability of smartphone-based software application (app) for tracking refill data in...
The coronavirus disease of 2019 (COVID-19) pandemic exacerbated barriers to care for people living with human immunodeficiency virus (HIV) (PLWH). quick uptake telemedicine in the outpatient setting provided promise continuity. In this study, we compared appointment and laboratory no-show rates an urban HIV clinic during three time periods: (1) Pre-COVID-19: 9/15/2019-3/14/2020 (predominately in-person), (2) "Early" COVID-19: 3/15/2020-9/14/2020 telemedicine), (3) "Later" 9/15/2020-3/14/2021...
Abstract Mycobacterium avium complex (MAC) colitis is a rare complication of immunosuppression in solid organ transplant (SOT) recipients. Here, we describe case disseminated MAC infection with following renal transplantation. Despite common pathways immunosuppression, SOT recipients and human immunodeficiency virus (HIV)‐infected patients differ their typical presentations infection. Intestinal infections have been more commonly reported HIV‐infected than The explanation for this difference...
People living with HIV (PLWH) engaged in medical care represent an accessible group to focus prevention efforts. In analysis of 1,883 PLWH from 2007 and 2015, we determined the proportion at risk transmission identified factors associated using multivariable mixed effects logistic regression models random intercepts. was defined by viral load > 1,500 copies/mL self-reported unprotected sex. We found that 174 (9.2%) individuals were for least once. Factors included younger age (adjusted OR...
In 2012, the Centers for Disease Control and Prevention released updated guidelines recommending universal, one-time hepatitis C virus screening all individuals born between 1945 1965. Prior to implementation of these guidelines, testing rates were inappropriately low, but unnecessary duplicate antibody was also problematic. era increased efforts screen "baby boomers", prevalence social determinants initial have not been well described.A program implemented at six urban primary care clinics...
Background Elevated cytokine release and T cell exhaustion have been associated with COVID-19 disease severity. activity may be indirectly measured through interferon gamma assays (IGRAs), which use mitogen stimulation of lymphocytes as a positive control. In our institution, an unexpectedly high rate indeterminate IGRAs was noted in COVID-19–positive patients. We aimed to evaluate the clinical characteristics IGRA results difference responses between COVID-19–negative Methods reviewed all...
Hepatitis C virus (HCV) infection disproportionately affects HIV-infected patients. Co-infected patients have worse prognoses than mono-infected HCV treatment with new oral direct acting antiviral (DAA) therapy is effective in HIV/HCV co-infected cure rates similar to Despite the treatments, only a small proportion of are treated for infection. This study aims describe barriers hepatitis We performed retrospective observational seen at an urban HIV clinic year 2016 Drexel University,...
Infections are a common cause of morbidity and mortality in solid organ transplantation (SOT) recipients. Procalcitonin (PCT) has garnered attention as an inflammatory marker that been shown to be valuable for early identification systemic bacterial infection. However, interpretation PCTs value the different types infections, transplanted organs, post-operative courses can challenging. We review role PCT management infections SOT First, level elevated immediately after transplant surgery,...
Abstract Background In areas with a high prevalence of hepatitis C virus (HCV) infection, emergency department (ED) visits may provide unique opportunities for screening. The catchment area Hahnemann University Hospital (HUH) has an HCV seroprevalence rate >20%. However, limited data exist addressing testing strategies in the ED. This study describes experience piloting nurse-driven screening protocol urban hospital Methods A was developed and implemented on August 1, 2018. We performed...
Introduction: Cytomegalovirus (CMV) colitis is a rare disease among immunocompetent patients presenting with inflammatory bowel (IBD). CMV can cause steroid-refractory IBD, which may require antiviral and infliximab (IFX) combination therapy. Case Description/Methods: A 23-year-old woman was admitted for dehydration poor oral intake in the setting of eight bloody movements per day, tenesmus, weight loss. She presented to an outside hospital 5-weeks prior abdominal cramps bright red blood...
Abstract Background C. difficile (CD) testing is frequently ordered inappropriately. Highly sensitive polymerase chain reaction (PCR) tests can detect CD colonization leading to misdiagnosis. Providers often overlook other causes of diarrhea, notably laxatives. To improve diagnostic stewardship, our hospital introduced an electronic medical record (EMR)-based order set (OS). Methods In a 926-bed, teaching hospital, we conducted 3-step intervention stewardship. (1) A retrospective analysis...
Non-interferon based treatment regimens have transformed the therapeutic paradigm for hepatitis C infection. Universal one-time antibody testing is recommended by Centers Disease Control (CDC) Americans born between 1945 and 1965 (the Baby Boomer “birth-cohort”). Limited data exists addressing strategies in primary care settings. This study aims to describe experience of universal birth-cohort six large setting clinics. We performed a cross sectional clinics from 2007 2016. Patients who were...