A5028523690- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Neurotransmitter Receptor Influence on Behavior
- Forensic Toxicology and Drug Analysis
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Diagnosis and treatment of tuberculosis
- Cannabis and Cannabinoid Research
- Human Rights and Development
- Immune responses and vaccinations
- Global Security and Public Health
- Inhalation and Respiratory Drug Delivery
- Oral and gingival health research
- Oral and Maxillofacial Pathology
- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- Oral Health Pathology and Treatment
- SARS-CoV-2 and COVID-19 Research
- TGF-β signaling in diseases
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Tumors Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Chemokine receptors and signaling
- Cancer Immunotherapy and Biomarkers
- Neuroscience of respiration and sleep
Science and Technology Policy Institute
2020
University of Pittsburgh
2014-2019
University of California, San Francisco
1994
Although recent studies in mice have shown that components of B cell and humoral immunity can modulate the immune responses against Mycobacterium tuberculosis, roles these human nonhuman primate infections are unknown. The cynomolgus macaque (Macaca fascicularis) model M. tuberculosis infection closely mirrors outcomes pathology (TB). present study used rituximab, an anti-CD20 antibody, to deplete cells tuberculosis-infected macaques examine contribution control TB primates during acute...
For many pathogens, including most targets of effective vaccines, infection elicits an immune response that confers significant protection against reinfection. There has been debate as to whether natural Mycobacterium tuberculosis (Mtb) Here we experimentally assessed the conferred by concurrent Mtb in macaques, a robust experimental model human (TB), using combination serial imaging and challenge strains differentiated DNA identifiers. Strikingly, ongoing provided complete establishment...
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis, continues to be a major global health problem. Lung granulomas are organized structures of host immune cells that function contain the bacteria. Cytokine expression is critical component protective response, but inappropriate cytokine can exacerbate TB. Although importance proinflammatory cytokines in controlling M. tuberculosis infection has been established, effects anti-inflammatory cytokines, such as IL-10, TB less well...
Tuberculosis (TB) chemotherapy clears bacterial burden in the lungs of patients and allows tuberculous lesions to heal through a fibrotic process. The healing process leaves pulmonary scar tissue that can impair lung function. goal this study was identify mediators as stepping-stone begin exploring mechanisms repair TB. Hematoxylin eosin staining Masson's trichrome stain were utilized determine levels collagenization granulomas from non-human primates. Immunohistochemistry then employed...
The hallmarks of pulmonary Mycobacterium tuberculosis infection are lung granulomas. These organized structures composed host immune cells whose purpose is to contain or clear infection, creating a complex hub and bacterial cell activity, as well limiting pathology in the lungs.
As of July 2020, COVID-19 has caused over 600,000 deaths, with 17 million confirmed cases, and counting. The World Health Organization (WHO), the global governance organization charged providing health for all, declared a pandemic on March 11, signaling beginning response to disease. Despite commitment human rights health, WHO others have been virtually silent how management go together, largely relied techniques that date back 1918 flu epidemic. made painfully obvious tension between...
Reported are oral mucosal warts (HPV common antigen‐positive) from 7 adult HIV + patients in which there was cytologic atypia and disordered growth. Lesions were papillary, white to red color, located on the lip, gingiya, palate, tongue, buccal mucosa. Histologically, keratinocytes lesions exhibited atypical features form of hyper‐chromatism karyomegaly. Koilocytes frequently seen upper level where HPV antigen identified. The dysplastic areas, ranged mild severe, typically showed abrupt...
Abstract Tuberculosis (TB) continues to be a major global health problem, causing 1.5 million deaths in 2014. To curb TB, several TB vaccine candidates are currently various stages of testing. We investigated the importance vaccination route immune response and protection against non-human primate (NHP) model. vaccinated cynomolgus macaques with protein subunit (H56) admixed novel adjuvant (CAF09) by three routes—intranasal, subcutaneous, aerosol. Immunogenicity was measured intracellular...
There has been a growing concern over human exposure to Mycobacterium avium subspecies hominissuis (MAH) through drinking water due its ubiquitous presence in natural waters and remarkable resistance both chemical physical disinfectants treatment processes. However, little is known about the effectiveness of physico-chemical processes remove MAH. Therefore, we determined removal MAH by alum coagulation, flocculation sedimentation optimized conditions using standard jar test equipment....
Abstract Tuberculosis (TB), a deadly infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). The is characterized development of granulomas consisting immune cells that form cluster around bacteria to limit bacterial growth and outcomes. Control TB epidemic limited complicated drug regimen, antibiotic resistance, lack an effective vaccine against infection disease. Fibrosis common in older granulomas, has been associated with both positive negative Little known about...
Abstract Tuberculosis (TB), caused by M. tuberculosis (Mtb), continues to be a global health problem. Lung granulomas, organized structures of host immune cells contain Mtb, are the pathologic hallmark TB. T cell cytokines play major role in containment Mtb infection within these granulomas. While importance pro-inflammatory IFN-γ and TNF controlling infections has been established, effects immunomodulatory cytokines, such as IL-10, less well understood. We used cynomolgus macaques,...
For many pathogens, including most targets of effective vaccines, infection elicits an immune response that confers significant protection against reinfection. There has been debate as to whether natural M. tuberculosis (Mtb) Here we experimentally assessed the conferred by concurrent Mtb nfection in macaques, a robust experimental model human (TB), using combination serial imaging and challenge strains differentiated DNA identifiers. Strikingly, ongoing provided complete establishment...
Abstract Tuberculosis (TB), caused by M. tuberculosis (Mtb), continues to be a leading cause of deaths from infectious diseases worldwide. Active TB disease has been associated with suppressed T cell responses and increased production immunosuppressive cytokines, particularly IL-10. However, published research focused on the systemic immune response Mtb as measured in blood. Little is known about local within individual granulomas. Using cynomolgus macaque model infection, we quantified...
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health problem. Several TB vaccine candidates are currently in various stages of development and clinical testing, including the protein subunit H56, from Statens Serum Institute (Copenhagen, Denmark). The cationic liposome adjuvant CAF09 was recently developed to enhance CD4 CD8 T cell response when administered with H56 vaccine. We vaccinated non-human primates (NHP) intranasal subcutaneous...