A5073816029- LGBTQ Health, Identity, and Policy
- HIV/AIDS Research and Interventions
- Pregnancy and Medication Impact
- HIV/AIDS drug development and treatment
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Bipolar Disorder and Treatment
- Pharmacological Effects and Toxicity Studies
- Hypothalamic control of reproductive hormones
- Ethics in Clinical Research
- Statistical Methods in Clinical Trials
- Tuberculosis Research and Epidemiology
- Menopause: Health Impacts and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Myeloid Leukemia Treatments
- Mycobacterium research and diagnosis
- Estrogen and related hormone effects
- Contact Dermatitis and Allergies
- Reproductive Health and Technologies
- HIV Research and Treatment
- Reproductive Health and Contraception
- Cytokine Signaling Pathways and Interactions
- Adolescent Sexual and Reproductive Health
- Sex and Gender in Healthcare
University of Washington
2020-2024
Rutgers, The State University of New Jersey
2023
University of Nebraska Medical Center
2018-2020
University of Pittsburgh
2016
Although recent studies in mice have shown that components of B cell and humoral immunity can modulate the immune responses against Mycobacterium tuberculosis, roles these human nonhuman primate infections are unknown. The cynomolgus macaque (Macaca fascicularis) model M. tuberculosis infection closely mirrors outcomes pathology (TB). present study used rituximab, an anti-CD20 antibody, to deplete cells tuberculosis-infected macaques examine contribution control TB primates during acute...
Tuberculosis (TB) chemotherapy clears bacterial burden in the lungs of patients and allows tuberculous lesions to heal through a fibrotic process. The healing process leaves pulmonary scar tissue that can impair lung function. goal this study was identify mediators as stepping-stone begin exploring mechanisms repair TB. Hematoxylin eosin staining Masson's trichrome stain were utilized determine levels collagenization granulomas from non-human primates. Immunohistochemistry then employed...
Transgender people have unmet health needs related to chronic conditions such as dementia, osteoporosis and hypertension. Community-driven advocacy increased transgender representation in phase III trials for pharmacological prevention of HIV, but the extent which drug other included is unknown. We investigated drugs biologics represented across therapeutic areas on ClinicalTrials.gov.
Transwomen have an increased risk of HIV acquisition compared with other adults. Drug-drug interactions between pre-exposure prophylaxis (PrEP) and gender-affirming therapy are cited as a reason for poor PrEP uptake among transwomen. We evaluated plasma tenofovir emtricitabine pharmacokinetics their active intracellular anabolites, tenofovir-diphosphate emtricitabine-triphosphate, in transwomen receiving feminizing hormones.We enrolled HIV-negative (≥19 years) not PrEP. Participants took...
We evaluated the pharmacokinetics of double-dose levonorgestrel (LNG) implants to overcome drug-drug interaction with efavirenz-based antiretroviral therapy (ART).We conducted a nonrandomized, open-label, parallel-group, longitudinal pharmacokinetic study among Ugandan women ages 18-45 years. Participants HIV on ART containing efavirenz 600 mg received 300 LNG (Jadelle®, Bayer, New Zealand): 300LNG+ART group. compared our outcomes without using standard dose, 150 implants: 150LNG The implant...
Purpose: Serum hormone profiles among different feminizing gender-affirming therapies (GAHT) are poorly characterized. To address this gap, we described the serum estrogen of three 17β-estradiol preparations, taken with or without an antiandrogen, using a novel liquid chromatography–mass spectrometry (LC-MS/MS) assay in adults taking GAHT. Methods: This was secondary analysis 93 healthy transgender women and gender nonbinary GAHT prospective cross-sectional study. Eligible participants took...
Recently, an estradiol immunoassay manufacturer (Beckman Coulter, USA) issued 'important product notice' alerting clinical laboratories that their assay (Access Sensitive Estradiol) was not indicated for patients undergoing exogenous treatment. The objective of this analysis to evaluate bias relative liquid chromatography tandem mass spectrometry (LC-MS/MS) in transgender women and examine the influence unconjugated estrone on measurements.
Background Clinicians use sex-based kidney function estimating equations, but the appropriate sex modifier for transgender adults undergoing hormone therapy (HT) is undetermined. Objectives Compare median estimated creatinine clearance (eCrCL; Cockcroft-Gault) and glomerular filtration rates (eGFRs; Modification of Diet in Renal Disease [MDRD] Chronic Kidney Epidemiology Study [CKD-EPI]) before during HT when with without assigned at birth. Methods Single-system retrospective cohort study...
Background: Transgender and gender diverse (TGD) people have a high prevalence of psychotropic medication use, yet knowledge about the patient-level burden is limited.TGD patients may take hormone therapy to meet their expression goals.Potential drug-hormone interactions exist between medications therapy, requiring increased use for TGD adults undergoing therapy. Conclusion:Among on within two years one-third had polypharmacy.Most polypharmacy types appeared align with mental health...