A5006934979- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Adenosine and Purinergic Signaling
- Adolescent and Pediatric Healthcare
- Biochemical and Molecular Research
- Bipolar Disorder and Treatment
- Synthesis and Biological Evaluation
- Insect Resistance and Genetics
- Biotechnology and Related Fields
- Pharmaceutical studies and practices
- Enzyme Structure and Function
- Mosquito-borne diseases and control
- Protein Structure and Dynamics
- Protein Kinase Regulation and GTPase Signaling
- Insect and Pesticide Research
- Youth, Drugs, and Violence
- Respiratory viral infections research
- Complement system in diseases
- Phytochemical compounds biological activities
- Education during COVID-19 pandemic
- Environmental Sustainability and Education
- Blood groups and transfusion
Universidade Federal de Viçosa
2012-2024
Background Visceral leishmaniasis is an important tropical disease, and Leishmania infantum chagasi (synonym of infantum) the main pathogenic agent visceral in New World. Recently, ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases) were identified as enablers infection virulence factors many pathogens. Two putative E-NTPDases (∼70 kDa ∼45 kDa) have been found L. genome. Here, we studied E-NTPDase from to describe its natural occurrence, biochemical characteristics influence on...
Canine visceral leishmaniasis is an important public health concern. In the epidemiological context of human leishmaniasis, dogs are considered main reservoir Leishmania parasites; therefore, must be epidemiologically monitored constantly in endemic areas. Furthermore, dog to transmission has been correlated with emerging urbanization and increasing rates infection worldwide. (Leishmania) infantum (L. chagasi) etiologic agent New World. this work, a new L. (L.) recombinant antigen, named ATP...
Previous work has suggested that Trypanosoma cruzi diphosphohydrolase 1 (TcNTPDase-1) may be involved in the infection of mammalian cells and serve as a potential target for rational drug design. In this work, we produced recombinant TcNTPDase-1 evaluated its nucleotidase activity, cellular localization role parasite adhesion to host cells. was able utilize broad range triphosphate diphosphate nucleosides. The enzyme's Km ATP (0.096 mM) capability influence host's ATP-dependent purinergic...
Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences 1.2 and 0.4 million cases per year, respectively. The treatment these relies on multiple parenteral injections pentavalent antimonials or amphotericin B. However, pharmaceuticals either too toxic expensive for routine use in developing countries. These facts call safer, cheaper, more effective new antileishmanial...
Canine visceral leishmaniasis (CVL) has been the theme of several studies given importance dog as natural reservoir pathogen Leishmania infantum in endemic regions and its role on dissemination CVL human Lesihmaniasis (VL). The current immunodiagnosis limitations concerning accuracy, specificity sensitivity. Therefore, improvements are required. rLiNTPDase2 previously highlighted a new recombinant antigen from L. to diagnosis by ELISA assay (rLiNTPDase2-ELISA). In this study, we aimed...