A5078538181- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Ion channel regulation and function
- Molecular Biology Techniques and Applications
- Memory and Neural Mechanisms
- Neonatal and fetal brain pathology
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Mentoring and Academic Development
- Contact Dermatitis and Allergies
- Mitochondrial Function and Pathology
- AI in cancer detection
- Speech and Audio Processing
- Virus-based gene therapy research
- Traumatic Brain Injury Research
- Heavy Metal Exposure and Toxicity
- CRISPR and Genetic Engineering
- Career Development and Diversity
- Interdisciplinary Research and Collaboration
University of Tübingen
2024
New York Stem Cell Foundation
2019-2022
University of Pennsylvania
2005-2007
Children's Hospital of Philadelphia
2005-2006
Drug discovery for diseases such as Parkinson's disease are impeded by the lack of screenable cellular phenotypes. We present an unbiased phenotypic profiling platform that combines automated cell culture, high-content imaging, Cell Painting, and deep learning. applied this to primary fibroblasts from 91 patients matched healthy controls, creating largest publicly available Painting image dataset date at 48 terabytes. use fixed weights a convolutional neural network trained on ImageNet...
Abstract Traumatic brain injury (TBI) is a significant health issue that often causes enduring cognitive deficits, in particular memory dysfunction. The hippocampus, structure crucial learning and memory, frequently damaged during TBI. Since long‐term potentiation (LTP) the leading cellular model underlying this study was undertaken to examine how affects area CA1 LTP mice using lateral fluid percussion (FPI). Brain slices derived from FPI animals demonstrated an inability induce 7 days...
Traumatic brain injury is a leading cause of death and disability in the United States. Pathological examinations humans animal models after demonstrate hippocampal neuronal damage, which may contribute to cognitive impairments. Data from our laboratories have shown that, at 1 week injury, mice possess significantly fewer neurons all ipsilateral subregions impairment. Since function distributed across both cerebral hemispheres, present paper explores morphological physiological response...
Drug discovery for diseases such as Parkinson’s disease are impeded by the lack of screenable cellular phenotypes. We present an unbiased phenotypic profiling platform that combines automated cell culture, high-content imaging, Cell Painting, and deep learning. applied this to primary fibroblasts from 91 patients matched healthy controls, creating largest publicly available Painting image dataset date at 48 terabytes. use fixed weights a convolutional neural network trained on ImageNet...
Crows, known for advanced cognitive abilities and vocal communication, rely on intricate auditory systems. While the neuroanatomy of corvid pathways is partially explored, underlying neurophysiological mechanisms are largely unknown. This study used functional ultrasound imaging (fUSi) to investigate sound-induced cerebral blood volume (CBV) changes in field L complex crow's telencephalon, a analogue mammalian cortex. FUSi revealed frequency-specific CBV responses, showing tonotopic...