A5003715846- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Autoimmune Neurological Disorders and Treatments
- Mosquito-borne diseases and control
- Metabolism and Genetic Disorders
- Glioma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- RNA regulation and disease
- Nanoplatforms for cancer theranostics
- Viral Infections and Outbreaks Research
- Advanced biosensing and bioanalysis techniques
- Ultrasound and Hyperthermia Applications
- Radiation Therapy and Dosimetry
- Adrenal Hormones and Disorders
- Platelet Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Climate Change and Health Impacts
- Mitochondrial Function and Pathology
- Hematological disorders and diagnostics
- RNA Interference and Gene Delivery
- Radiopharmaceutical Chemistry and Applications
- Vaccine Coverage and Hesitancy
- vaccines and immunoinformatics approaches
Soochow University
2024-2025
Peking University
2022-2024
Peking University International Hospital
2022-2024
Beijing Children’s Hospital
2020-2024
Capital Medical University
2020-2024
Beijing Ditan Hospital
2020-2022
Changzhi Medical College
2022
As the coronavirus disease 2019 (COVID-19) pandemic is still ongoing and severe acute respiratory syndrome 2 (SARS-CoV-2) variants are circulating worldwide, an increasing number of breakthrough infections being detected despite good efficacy COVID-19 vaccines. Data on 88 cases (breakthrough group) 41 unvaccinated (unvaccinated from June 1 to August 22, 2021, were extracted a cloud database established at Beijing Ditan Hospital evaluate clinical, immunological, genomic characteristics...
RNA degradation using ribonuclease targeting chimeras (RiboTACs) is a promising approach for cancer therapy. However, potential off-target serious issue. Here, RiboTAC designed tumor microenvironment triggered activation. The activated (TaRiboTAC) incorporates two pre-miR-21 binders, near-infrared fluorophore IR780, an RGD peptide and phenylboronic acid caged recruiter. recruiter embedded in the molecule exposed acidic pH, cage removed by H2O2 making TaRiboTAC responsive to high levels...
Abstract C‐reactive protein‐to‐albumin ratio (CAR) can be used to assess the prognosis of various diseases. This study aimed evaluate relationship between CAR on patients with severe fever thrombocytopenia syndrome (SFTS). included 155 SFTS from Public Health Clinical Center Dalian January December 2021. They were divided into survival and deceased groups based clinical prognosis. The independent risk factors for poor at an early stage determined by Cox regression. efficacy prediction was...
Radiotherapy (RT)-induced in situ vaccination greatly promotes the development of personalized cancer vaccines owing to massive release antigens initiated by tumor-localized RT eliciting tumor-specific immune response. However, its broad application treatment is seriously impeded poor antigen cross-presentation, low response rate, and short duration efficacy. Herein, tumor-antigen-capturing nanosystem dAuNPs@CpG consisting gold nanoparticles, 3,5-cyclohexanedione (CHD), immunoadjuvant CpG...
Background Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne phlebovirus a high fatality rate. Previous studies have demonstrated the poor prognostic role of eosinophils (EOS) and basophils (BAS) in predicting multiple viral infections. This study aimed to explore EOS BAS prognosis patients SFTS. Methodology A total 194 SFTS who were admitted Yantai City Hospital from November 2019 2021 included. Patients’ demographic clinical data collected....
Objective. The purpose of this paper is to analyse the correlation between cardiac ultrasound-related indicators and function in patients with coronary heart disease failure. Methods. In experiment, a total 160 failure who were diagnosed treated our hospital from June 2019 March 2021 recruited as study group. All examined by colour Doppler ultrasound instrument, SPSS statistical software was used data obtained, Spearman Results. group, there 68 grade II function, accounting for 42.50%; 74...
Objective: To summarize the clinical and genetic characteristics of children with mitochondrial epilepsy. Methods: Clinical data 62 who were clinically genetically diagnosed epilepsy by Department Neurology, Beijing Children's Hospital from October 2011 to December 2018 analyzed retrospectively, control was followed up. T test or χ(2) used analyze related factors affecting prognosis between effective group ineffective group. Results: Of patients, 33 male 29 female. The age onset 3.38...
To summarize the clinical and prognostic features of children with opsoclonus-myoclonus-ataxia syndrome (OMAS).
Objective: To investigate the clinical features, imaging findings and prognosis of children with overlapping syndrome myelin oligodendrocyte glycoprotein (MOG) antibody disease anti-N-methyl-D aspartate receptor (NMDAR) encephalitis (MNOS). Methods: The manifestations, immunological antibodies in blood cerebrospinal fluid, cranial image, treatment follow-up 11 patients diagnosed as MNOS Department Neurology, Beijing Children's Hospital from January 2011 to April 2019 were analyzed...
Objective: To characterize fever-induced paroxysmal weakness and encephalopathy (FIPWE) caused by ATP1A3 gene pathogenic variant. Methods: Phenotypic genotypic characteristics of 4 FIPWE patients (3 boys 1 girl), who were ascertained from October 2016 to March 2018 in Beijing Children's Hospital due heterozygous variants, retrospectively analyzed. The whole exsome sequencing was used for genetic testing. Results: onset ages 2 years 9 months, 8 5 months respectively. episode ranged 3 times,...
Objective: To describe the clinical features of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-positive cortical encephalitis in children. Methods: Patients who were hospitalized Beijing Children's Hospital from June 2018 to October 2019, with positive MOG antibodies and phenotype retrospectively analyzed. Cell-based assays (CBAs) used test antibodies. Results: Five patients had during follow-up, 3 females 2 males. The age onset ranged 8 years 12 1 month. At last cases exhibited a...
Objective: To summarize the clinical characteristics of SYNGAP1-related epilepsy in children. Methods: Data 13 patients with SYNGAP1 gene variants diagnosed at Department Neurology, Beijing Children's Hospital were collected retrospectively from March 2017 to October 2020 and followed up. The features, electroencephalogram(EEG), brain imaging, results treatment summarized. Results: Twelve up successfully among variants. last follow-up age was 5 years 7 months (3 1 month 9 years).The onset...
Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Methods: A comprehensive literature search of PubMed, Web Science, Embase, Cochrane Library, Chinese National Knowledge Infrastructure databases, Wan Fang Data, Sinomed Database, and VIP Database was conducted on articles which have described the gender differences. Data from selected studies were pooled using STATA VERSION 15.0 software.Results: Finally, four...
Abstract Objectives As the COVID-19 pandemic is still ongoing and SARS-CoV-2 variants are circulating worldwide, an increasing number of breakthrough infections have been detected despite good efficacy vaccines. Methods A prospective, comparative cohort study was conducted in Beijing Ditan Hospital to evaluate clinical, immunological genomic characteristics infections. Data on 88 cases (vaccinated group) 41 unvaccinated (unvaccinated from June 1 August 20, 2021 were extracted a cloud...