Zhan Hu

ORCID: 0000-0002-5152-8951
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Research Areas
  • X-ray Diffraction in Crystallography
  • Natural Compounds in Disease Treatment
  • Crystallization and Solubility Studies
  • Plant Parasitism and Resistance
  • Phytochemical compounds biological activities
  • Natural product bioactivities and synthesis
  • Plant tissue culture and regeneration
  • Insect and Pesticide Research
  • Plant and animal studies
  • Nematode management and characterization studies
  • Insect Pest Control Strategies
  • Chemical synthesis and alkaloids
  • Plant and fungal interactions
  • Fungal Plant Pathogen Control
  • Solid-state spectroscopy and crystallography
  • Crystal Structures and Properties
  • Allelopathy and phytotoxic interactions
  • Plant Pathogens and Fungal Diseases
  • Advanced Semiconductor Detectors and Materials
  • Plant-Microbe Interactions and Immunity
  • Catalytic C–H Functionalization Methods
  • Catalytic Cross-Coupling Reactions
  • Traditional and Medicinal Uses of Annonaceae
  • Legume Nitrogen Fixing Symbiosis
  • Phytochemicals and Antioxidant Activities

Anhui Agricultural University
2025

Hainan University
2019-2025

Nankai University
2018-2025

Hunan University
2024

Northwest A&F University
2011-2019

Hunan University of Science and Engineering
2018

Yong In University
2018

Dalian University of Technology
2006

Shanghai University of Traditional Chinese Medicine
1993

Heinrich Heine University Düsseldorf
1992

Two new triterpenoid saponins, namely camsinsaponins A and B (1, 2), along with two known congeners (3, 4) were isolated from Camellia sinensis flowers. Their structures determined by extensive spectroscopic data. All compounds assessed for antifungal bioactivity against Candida albicans, glabrata, tropicalis. Compounds 1–4 showed excellent inhibitory effects. Notably, in regard to 1 2, their MIC values C. albicans close those of the positive control, fluconazole. Furthermore, elements on...

10.3390/ijms26031147 article EN International Journal of Molecular Sciences 2025-01-28

A convenient and efficient indium-catalyzed approach to synthesize alkenyl iodides has been developed through direct iodoalkylation of alkynes with alcohols aqueous HI under mild conditions. This catalytic protocol offers an attractive for the synthesis a diverse range in good excellent yields.

10.1039/c8ob00183a article EN Organic & Biomolecular Chemistry 2018-01-01

Plant viral diseases cause great harm to crops in terms of yield and quality. Natural products have been providing an excellent source novel chemistry, inspiring the development synthetic pesticides. The Amaryllidaceae alkaloids crinasiadine (3a), trisphaeridine (4a), bicolorine (5a) were selected as parent structures, a series their derivatives designed, synthesized, investigated for anti-plant virus effects first time. Compounds 13b 18 exhibited comparable inhibitory activities...

10.3390/ijms26031103 article EN International Journal of Molecular Sciences 2025-01-27

Ralstonia solanacearum is an important pathogen causing bacterial wilt in pepper (Capsicum annuum L.). The concurrent infection of R. and root-knot nematodes (Meloidogyne spp.) exacerbates the severity pepper. Utilizing plant endophytic bacteria to control these mixed diseases a viable strategy. Waltheria indica L. (Sterculiaceae) traditional medicine plant. A total 209 were isolated from W. indica, Pseudomonas aeruginosa W-126 showed efficient antagonistic effect against solanacearum. Based...

10.3390/ijms26073335 article EN International Journal of Molecular Sciences 2025-04-03

polysaccharides have a variety of pharmacological effects. The commonly used extraction methods include traditional hot water extraction, alkaline enzymatic hydrolysis method, ultrasonic-assisted etc., but there are problems such as low yield, high temperature, cost, strict conditions, and insufficient environmental protection. In this study, crude polysaccharide from the

10.3390/molecules29204879 article EN cc-by Molecules 2024-10-14

A series of N-aryl-pyridine-4-one derivatives were designed and synthesized using maltol antidesmone as lead compounds, then their fungicidal/bactericidal activities possible mechanism action against Colletotrichum musae explored. Most these compounds exhibited significant fungicidal activity in vitro. Especially, compound 23 has more than 90% inhibitory nine plant pathogenic fungi at 50 μg mL–1, which is superior to azoxystrobin. Moreover, an vivo bioassay also demonstrated that...

10.1021/acs.jafc.9b06296 article EN Journal of Agricultural and Food Chemistry 2019-11-25

Abstract BACKGROUND Botanical pesticides play an important role in organic agricultural practices and are widely used integrated pest management (IPM). Uvaria grandiflora was mainly reported as traditional medicines possessed antibacterial, antioxidant, antiprotozoal activities. Therefore, biological activities of U. may suggest that they have the potential to be botanical pesticides. RESULTS The extract exhibited broad‐spectrum inhibitory activity toward phytopathogenic fungi oomycetes,...

10.1002/ps.6580 article EN Pest Management Science 2021-07-27

The discovery of novel leads and new mechanisms action is vital significance to the development pesticides. To explore lead compounds for botanical insecticides, 77 β-dihydroagarofuran derivatives were designed synthesized. Their structures mainly confirmed by 1H NMR, 13C DEPT-135°, IR, MS, HRMS. insecticidal activity was evaluated against third-instar larvae Mythimna separata Walker, results indicated that, these derivatives, eight exhibited more promising than positive control,...

10.1021/acs.jafc.5b05782 article EN Journal of Agricultural and Food Chemistry 2016-02-06

In order to develop new biorational pesticides, ten 6-substituted ester derivatives of Celangulin-V were designed and synthesized. The structures the confirmed by IR, 1H-NMR, 13C-NMR ESI-MS spectral analysis. Insecticidal activities these compounds tested against third-instar larvae Mythimna separata. Two (1.1, 1.2) showed higher insecticidal than Celangulin-V, with mortality 75.0% 83.3%, respectively. While four (1.3, 1.4, 1.7, 1.8) denoted lower activities, others (1.5, 1.6, 1.9, 1.10)...

10.3390/ijms12129596 article EN cc-by International Journal of Molecular Sciences 2011-12-20

Abstract BACKGROUND Lycoris aurea (L' Herit.) Herb (Amaryllidaceae) is a native pesticide in China. The ethanolic extract of aureate bulbs, the total alkaloids L. bulbs and main were systematically investigated as part novel project to study their antiviral, fungicidal (phytopathogenic) insecticidal activities. We also prepared 18 lycorine derivatives evaluated bioactivities. RESULTS Lycorine had excellent larvicidal activity against Plutella xylostella (LC 50 = 10.6 mg L −1 ) was effective...

10.1002/ps.5065 article EN Pest Management Science 2018-05-08

To identify natural nematicides that can replace chemical nematicides, 2-naphthol with high activity against Meloidogyne incognita was isolated from Actephila merrilliana. The nematicidal of M. 100% at 100 μg/mL an EC50 value 38.00 μg/mL. Moreover, had a significant negative effect on egg incubation. 2-Naphthol effectively inhibited the invasion into crops in both pot experiment and field trial. In addition, structure-activity relationship indicated naphthalene ring its β-site hydroxyl group...

10.1021/acs.jafc.3c02580 article EN Journal of Agricultural and Food Chemistry 2023-08-29

1β, 2β, 4α, 6α, 8β, 9α, 12-hepthydroxyl-β-dihydroagarofuran is the main skeleton of β-dihydroagarofuran sesquiterpenoids, which exhibit excellent insecticidal activity. To study further structure-activity relationship sesquiterpenoids towards finding novel botanical pesticides, two series new structurally modified ether analogues were designed and synthesised, their activities evaluated.Twenty-two derivatives synthesised using as starting material. Bioassay results indicated that most...

10.1002/ps.4049 article EN Pest Management Science 2015-05-28

In the current work, a series of 1-trifluoromethyl cinnamyl alcohol derivatives were designed and synthesized their antifungal activities evaluated. The bioassay result showed that most compounds exhibited excellent activity in vitro at 10 μg mL–1. Next, photostable easily compound 2 with broad-spectrum was selected as potential candidate to evaluate its antibacterial activities. EC50 values against eight fungal plant pathogens ranged from 3.806 17.981 mL–1; same time, could effectively...

10.1021/acs.jafc.1c00272 article EN Journal of Agricultural and Food Chemistry 2021-05-04

In order to develop new biorational pesticides and clarify the potential structural factors needed for biological activity of celangulin-V analogues, thirty novel nitrogenous derivatives were designed synthesized. The single crystal structure is reported first time provides a more accurate than that previously reported. structures all confirmed by either NMR or ESI-MSn analysis. Insecticidal activities these compounds tested against third-instar larvae Mythimna separata. One derivative (1-6)...

10.1177/1934578x1400900603 article EN Natural Product Communications 2014-06-01

Twelve new triazole derivatives of Phrymarolin were prepared from I and the structures all fully characterized by 1H-NMR, 13C-NMR MS spectral data analyses. Larvicidal activities against 4rd instar larvae Culex pipiens pallens these analogues assayed. Although showed certain larvicidal activity, they lower activity than I. The typical non-natural groups substituents reduced derivatives.

10.3390/ijms141224064 article EN cc-by International Journal of Molecular Sciences 2013-12-10

The title compound, [Co(C2H8N2)3]AsS4, was synthesized under solvothermal conditions in ethyl­enediamine (en) at 413 K. compound consists of octa­hedral [Co(en)3]3+ cations and tetra­hedral AsS43− anions.

10.1107/s1600536806039031 article EN Acta Crystallographica Section E Structure Reports Online 2006-09-30

The title compound, [Ni(C2H8N2)3]2[Sn2Se6], was synthesized under solvothermal conditions in an ethyl­enediamine/water solution at 453 K. compound contains discrete centrosymmetric [Sn2Se6]4− anions, which are dimers of two tetra­hedral SnSe4 groups sharing a common edge. transition metal cation is six-coordinated by three ethyl­enediamine mol­ecules octa­hedral geometry.

10.1107/s1600536806038050 article EN Acta Crystallographica Section E Structure Reports Online 2006-09-27

Southern root-knot nematodes are among the most pernicious phytoparasites; they responsible for substantial yield losses in agricultural crops worldwide. The limited availability of nematicides prevention and control plant-parasitic necessitates urgent development novel nematicides. Natural products have always been a key source discovery pesticides. Waltherione A, an alkaloid, exhibits potent nematocidal activity. In this study, we designed synthesized series quinoline quinolone derivatives...

10.3390/ijms25179209 article EN International Journal of Molecular Sciences 2024-08-25

Imidacloprid (IMI) stress positively correlates with the potential of coumarins to alleviate abiotic stress. However, little is known about pathways and mechanisms by which coumarin reduces IMI residue regulating plant secondary metabolism plant–microbe interactions. This study examined impact on uptake, translocation, in pepper plants modulating signal molecule levels microbial communities rhizosphere phyllosphere. Analysis 2 h─28 d pesticide dynamics revealed that dramatically reduced...

10.1021/acs.jafc.4c10038 article EN Journal of Agricultural and Food Chemistry 2024-12-28
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