A5085401966- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Cancer Research and Treatments
- Immune responses and vaccinations
- vaccines and immunoinformatics approaches
- Single-cell and spatial transcriptomics
- Peptidase Inhibition and Analysis
- Fungal Infections and Studies
- Inflammasome and immune disorders
- Genetic factors in colorectal cancer
- Immune cells in cancer
- Electrochemical sensors and biosensors
- Circular RNAs in diseases
- Analytical Chemistry and Sensors
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Signaling Pathways in Disease
- Immune Cell Function and Interaction
Universidad Argentina de la Empresa
2023-2024
Experimental Medicine and Biology Institute
2019-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2019-2023
Instituto de Desarrollo Tecnológico para la Industria Química
2023
Although immune checkpoint blockers have yielded significant clinical benefits in patients with different malignancies, the efficacy of these therapies is still limited. Here, we show that disruption transmembrane protein 176B (TMEM176B) contributes to CD8+ T cell-mediated tumor growth inhibition by unleashing inflammasome activation. Lack Tmem176b enhances antitumor activity anti-CTLA-4 antibodies through mechanisms involving caspase-1/IL-1β Accordingly, responding blockade display an...
Abstract Non-melanoma skin cancer (NMSC) has risen dramatically as a result of chronic exposure to sunlight ultraviolet (UV) radiation, climatic changes and clinical conditions associated with immunosuppression. In spite considerable progress, our understanding the mechanisms that control NMSC development their molecular immunological landscapes is still limited. Here we demonstrated critical role for galectin-7 (Gal-7), β-galactoside-binding protein preferentially expressed in tissue,...
The accurate quantification of tumor-infiltrating immune cells turns crucial to uncover their role in tumor escape, determine patient prognosis and predict response checkpoint blockade. Current state-of-the-art methods that quantify from biopsies using gene expression data apply computational deconvolution present multicollinearity estimation errors resulting the overestimation or underestimation diversity infiltrating quantity. To overcome such limitations, we developed MIXTURE, a new...
Abstract RNA sequencing has proved to be an efficient high-throughput technique robustly characterize the presence and quantity of in tumor biopsies at a given time. Importantly, it can used computationally estimate composition immune infiltrate infer immunological phenotypes those cells. Given significant impact anti-cancer immunotherapies role associated microenvironment (ITME) on its prognosis therapy response, estimation cell-type content is crucial for designing effective strategies...
e15154 Background: The analysis of somatic genomic alterations, evaluation DNA mismatch repair (MMR) proteins, and examination PD-L1 expression in tumor biopsies are crucial for prognosis informed therapeutic decisions. However, their clinical implementation Argentina faces challenges due to economic costs lack evidence. To address this, we conducted a retrospective study assess the impact this molecular panel testing on treatment decisions management cancer patients Argentina. Additionally,...
e15198 Background: Immunotherapies have revolutionized cancer treatment, but responses are not universal and patients who initially respond to therapy develop resistance. The accurate quantification of tumor-infiltrating immune cells holds the promise reveal role system in human cancers its involvement tumor escape mechanisms response therapy. We present MIXTURE, a new algorithm for cell-type proportions deconvolution from transcriptomic data that overcomes competitive methods revealed novel...
Background: In spite of compelling evidence demonstrating safety and immunogenicity adenoviral-based SARS-CoV-2 vaccines in the general population, its effects socially vulnerable elderly individuals are poorly understood. Here we aimed to investigate efficacy two doses combined vector vaccine, Gam-COVID-Vac (Sputnik-V vaccine), at 14, 42, 180 days after immunization, a nursing home for underprivileged population homeless individuals. Methods: A phase 3, open-label clinical trial involving...
Abstract Both targeted therapies (TT) and immunotherapies have revolutionized the treatment of metastatic melanoma patients. Particularly, TT with BRAFi or BRAFi/MEKi leads to prompt but not durable responses in most patients due development resistance within 1 year. Tumors refractory derive little benefit from subsequent immunotherapy. Here we aim elucidate how previous treatments shape tumor-immune landscape it could be overcome therapeutically. Firstly, analyzed gene expression profile a...
Abstract Although the development of single-cell RNAseq (scRNAseq) has improved knowledge tumor microenvironment (TME), there is not a clear understanding specific cell subtypes, markers that define these populations, nor interaction between them. Previously, we showed inflammasome activation correlated with antitumor responses triggered by immune checkpoint blockade (ICB). This highlights central role for TMEM176B, mostly expressed in myeloid cells, impairs recruitment cytotoxic cells TME...
Abstract Aberrant glycosylation has emerged as an important hallmark of cancer playing a critical role in the modulation tumor cell aggressiveness, invasiveness, and immune vascular programs. However, cellular molecular mechanisms implicated glycan-driven progression remain poorly understood. In this study, we explored expression profile glycosylation-related gene signature (Affymetrix, GlycoV4) its association with tumors from different primary sites. First, analyzed published...
<h3>Background</h3> Although immunotherapies have emerged as efficient strategies for treating cancer, biomarkers outcome prediction are still under debate. Relevant such PD-L1, tumor mutational burden, and microsatellite instability (MSI) shown limited efficacy stand-alone markers.<sup>1 2</sup> Moreover, aberrant glycosylation has been associated to development, but its potential predict immunotherapy outcomes barely explored.<sup>3</sup> We studied the expression of glyco-immune genes...
Endogenous lectins play key roles in cell homeostasis by decoding the information encrypted glycans present on surface or extracellular matrix. Galectins, a family of soluble lectins, have emerged as central regulators innate and adaptive immune responses. In this article, we review seminal work demonstrating immunoregulatory Galectin-1 (Gal-1), proto-type member galectin family, highlight mechanisms that control its functions cancer autoimmune inflammation. Understanding cellular pathways...
Abstract Most melanoma patients who develop resistance to targeted therapies do not respond subsequent immunotherapy. Therefore, establishing which would derive clinical benefit from immunotherapy is a compelling question. We performed meta-analysis of published transcriptome datasets biopsies before and after development BRAFi or BRAFi/MEKi. observed an increase in M2-macrophages infiltrate by CIBERSORT relapsed as well T-cell exhaustion markers immunosuppressive cytokines. Our preliminary...
<title>Abstract</title> <bold>Background </bold>In spite of compelling evidence demonstrating safety and immunogenicity adenoviral-based SARS-CoV-2 vaccines in the general population, its effects socially vulnerable elderly individuals is poorly understood Here we aimed to investigate efficacy two doses combined vector vaccine, Gam-COVID-Vac (Sputnik V), at 14, 42 180 days after immunization, a nursing home for low-income homeless individuals. <bold>Methods: </bold>A phase 3, open-label...