A5068707033- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Neutropenia and Cancer Infections
- Protein Tyrosine Phosphatases
- Colorectal Cancer Treatments and Studies
- Signaling Pathways in Disease
- Invertebrate Immune Response Mechanisms
- Immune Response and Inflammation
- Chemokine receptors and signaling
- SARS-CoV-2 and COVID-19 Research
- Inflammatory mediators and NSAID effects
- COVID-19 Clinical Research Studies
- Macrophage Migration Inhibitory Factor
- Toxin Mechanisms and Immunotoxins
- Cancer Cells and Metastasis
- Axon Guidance and Neuronal Signaling
- Lung Cancer Treatments and Mutations
- Nerve injury and regeneration
- Bioactive Compounds and Antitumor Agents
Experimental Medicine and Biology Institute
2014-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2023
University of Buenos Aires
2010-2015
Instituto de Oncología de Rosario
2010
Significance Although immune checkpoint blockade therapies have achieved long-term responses in several malignancies, colorectal cancer (CRC) patients clinical benefit is observed only heavily mutated tumors that are mismatch-repair–deficient or high microsatellite instability. This limitation urges the identification of novel escape mechanisms and design additional immunotherapeutic modalities. We show Galectin-1 (Gal-1) confers privilege to CRC by increasing frequency CD8 + CD122 PD-1...
Hypoxia, angiogenesis, and immunosuppression have been proposed to be interrelated events that fuel tumor progression impair the clinical effectiveness of anti-tumor therapies. Here we present new mechanistic data highlighting role hypoxia in fine-tuning CD8 T cell exhaustion vitro , an attempt reconcile seemingly opposite evidence regarding impact on functional features exhausted cells. Focusing recently characterized terminally-differentiated progenitor cells, found both its regulated...
Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role allergic airway inflammation has not yet been elucidated. We evaluated the effects of Gal-1 on eosinophil function mouse model asthma. Allergen exposure resulted recruitment Gal-1-expressing cells, including eosinophils, well increased extracellular spaces lungs. In vitro, exerted divergent eosinophils that...
Abstract Myeloid cells (MCs) promote tumor progression by suppressing antitumor immunity and inducing angiogenesis. GAL1 is a carbohydrate-binding protein associated with poor prognosis, immune vascular reshaping across various cancers. Its binding can be disrupted ST6GAL1, sialyltransfase that adds α(2, 6)-linked sialic acid to poly-LacNAc structures. We studied the impact of ST6GAL1 in modulating immunoregulatory tumorigenic activity tumor-associated MCs exposure ligands. To study...
Abstract The Six Transmembrane Epithelial Antigen of the Prostate (STEAP1 and 2) metalloreductases are therapeutic targets for advanced PCa, their expression has been linked to androgen receptor (AR) signaling; however, regulatory mechanism function STEAP in PCa progression remains elusive. In this study, we explore how vitro modulation influences family cell lines with varying reliance on signaling. Our data show that response deprivation, STEAP1 STEAP2 exhibit elevated transcript levels,...
Abstract Myeloid-derived suppressor cells (MDSCs) are key regulatory that control inflammation and promote tumor-immune escape. To date, no specific immunomodulatory drug has proven efficacy in targeting the expansion and/or function of these different pathophysiologic settings. In this study, we identified a context-dependent effect nonsteroidal anti-inflammatory indomethacin (IND) on MDSCs, depending whether they were derived from tumor microenvironments (TME) or tumor-free (TFME)....
Bidirectional cross-talk between the neuroendocrine and immune systems orchestrates responses in both physiologic pathologic settings. In this study, we provide vivo evidence of a critical role for thyroid hormone triiodothyronine (T3) controlling maturation antitumor functions dendritic cells (DC). We used receptor (TR) β mutant mouse (TRβPV) to establish relevance T3-TRβ system vivo. model, TRβ signaling endowed DCs with ability stimulate antigen-specific cytotoxic T-cell during tumor...
Abstract Non-melanoma skin cancer (NMSC) has risen dramatically as a result of chronic exposure to sunlight ultraviolet (UV) radiation, climatic changes and clinical conditions associated with immunosuppression. In spite considerable progress, our understanding the mechanisms that control NMSC development their molecular immunological landscapes is still limited. Here we demonstrated critical role for galectin-7 (Gal-7), β-galactoside-binding protein preferentially expressed in tissue,...