A5025447036- Thyroid Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Growth Hormone and Insulin-like Growth Factors
- Bioactive Compounds and Antitumor Agents
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Estrogen and related hormone effects
- Plant-derived Lignans Synthesis and Bioactivity
- Stress Responses and Cortisol
- Phytochemical compounds biological activities
- Cancer, Hypoxia, and Metabolism
- Trace Elements in Health
- Retinoids in leukemia and cellular processes
- Essential Oils and Antimicrobial Activity
- DNA Repair Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Protein Kinase Regulation and GTPase Signaling
- Cancer-related Molecular Pathways
- Biochemical effects in animals
- Tryptophan and brain disorders
- Bioactive natural compounds
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Clinical Nutrition and Gastroenterology
- Cell death mechanisms and regulation
- Plant chemical constituents analysis
Consejo Nacional de Investigaciones Científicas y Técnicas
2009-2023
Pontificia Universidad Católica Argentina
2013-2023
University of Buenos Aires
2006-2019
Fundación Ciencias Exactas y Naturales
2014-2019
Institute of Astronomy and Space Physics
2007
Thyroid hormones play critical roles in differentiation, growth and metabolism, but their participation immune system regulation has not been completely elucidated. Modulation of vivo thyroid status was used to carry out an integrative analysis the role hypothalamus–pituitary–thyroid (HPT) axis T B lymphocyte activity. The protein kinase C (PKC) signaling pathway release some cytokines upon antigenic stimulation were analyzed. Lymphocytes from hyperthyroid mice displayed higher T-and B-cell...
Long-term exposure to stressful situations can affect the immune system. The T-cell response is an important component of anti-tumoral immunity. Hence, impairment function induced by a chronic stressor has been postulated alter immunosurveillance tumors, thus leading worse neoplastic prognosis. Here, we show that restraint stress affects mediated immunity in mice. This was evidenced decrease mitogen-induced proliferation, reduction CD4(+)T lymphocyte number and tumor necrosis factor-alpha...
Thyroid hormones (THs) exert a broad range of actions on development, growth, and cell differentiation by both genomic nongenomic mechanisms. THs regulate lymphocyte function, but the participation is still unknown. Here contribution effects TH-induced division T cells was studied using free noncell permeable coupled to agarose (TH-ag). THs-ag led division, lesser extent than hormones. induced nongenomically rapid translocation protein kinase C (PKC) ζ isoform membranes,...
Hyperthyroidism is an endocrine disorder characterized by excessive secretion of thyroid hormones T3 and T4. Thyroid exert pleiotropic actions on numerous tissues induce overall increase in metabolism, with energy demand oxygen consumption. Therefore, the purpose this study was to investigate effects hyperthyroidism production reactive species (ROS) lymph node spleen cells euthyroid hyperthyroid mice, analyzing antioxidant mechanisms involved restitution cellular redox state. For this,...
D-limonene is a common monoterpene found in nature. Previously, it has been demonstrated that antiproliferative effects on lymphoma cell line by increasing the nitric oxide (NO) level. In present work this mechanism analyzed evaluating participation of MAP38 and ERK pathways. Limonene increased NO levels inducing apoptosis two mechanisms: through production H2O2 pathway activation at low concentrations, inhibition farnesylation proteins O2− high concentrations. Both mechanisms were related...
Aqueous extracts or infusions obtained from the flowers of Tilia species are widely used for treatment anxiety in folk medicine. In this work, antiproliferative action aqueous, dichloromethane and ethanol cordata Mill. on tumoral (BW 5147 lymphoma) normal lymphocytes is described. Both showed a selective cells, inducing apoptosis. case T cells these suppressed mitogen-induced proliferation without affecting viability, suggesting suppressive but not cytotoxic effect. These effects were...
Regulation of cell proliferation by thyroid hormone (TH) has been demonstrated, but the effect THs and mechanisms involved in lymphocyte activity have not elucidated. Differential expression PKC isoenzymes high nitric oxide synthase (NOS) described tumor T lymphocytes. We analyzed direct actions TH on normal lymphocytes BW5147 lymphoma cells relation to NOS activities. increased mitogen-induced proliferation. isoenzyme-selective blockers impaired these effects both types, indicating...
Larrea divaricata is a plant with antiproliferative principles. We have previously identified the flavonoid quercetin-3-methyl ether (Q-3-ME) in an ethyl acetate fraction (EA). Both extract and Q-3-ME were found to be effective against EL-4 T lymphoma cell line. However, mechanism underlying inhibition of tumor proliferation remains elucidated. In this work, we analyzed role nitric oxide (NO) induction apoptosis mediated by EA. treatments able induce concentration-dependent time-dependent...
We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects THs on tumor development been studied, but results are still controversial. Herein, we show modulatory action status vivo growth For this purpose, euthyroid, hypothyroid, hyperthyroid mice received inoculations EL4 cells to allow solid tumors. Tumors animals exhibited a higher rate, as evidenced by early appearance palpable tumors increased volume....
The patient's hormonal context plays a crucial role in the outcome of cancer. However, association between thyroid disease and breast cancer risk remains unclear. We evaluated effect status on growth dissemination an immunocompetent mouse model. For this, hyperthyroid hypothyroid Balb/c mice were orthotopically inoculated with triple-negative 4T1 cells. Tumors from showed increased rate immunosuppressive tumor microenvironment, characterized by IL-10 levels decreased percentage activated...
Oxidative stress is an imbalance between the levels of reactive oxygen species (ROS), nitrogen (RNS) and endogenous antioxidants. The aetiology pathogenesis several oral diseases are attributed to this process. antioxidant enzymes secreted in saliva by submandibular glands maintain health through scavenging ROS. objective work was study capacity aqueous extract L. divaricata (AE), its majority compound, nordihydroguariaretic acid (NDGA), modulate pro-oxidant/antioxidant status a model...