A5073835138- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Adenosine and Purinergic Signaling
- Neurogenesis and neuroplasticity mechanisms
- Cannabis and Cannabinoid Research
- Immune cells in cancer
- Neurological Disease Mechanisms and Treatments
- Gut microbiota and health
- Sleep and Wakefulness Research
- Nicotinic Acetylcholine Receptors Study
- Mitochondrial Function and Pathology
- Memory and Neural Mechanisms
- Neonatal Health and Biochemistry
- Vagus Nerve Stimulation Research
- Biochemical effects in animals
- Receptor Mechanisms and Signaling
- Prion Diseases and Protein Misfolding
- Immune Response and Inflammation
- Heme Oxygenase-1 and Carbon Monoxide
- Barrier Structure and Function Studies
- Diet and metabolism studies
- Bioactive Compounds and Antitumor Agents
- Medicinal Plants and Neuroprotection
University of Florence
2016-2025
Ageing is accompanied by a decline in cognitive functions; along with variety of neurobiological changes. The association between inflammation and ageing based on complex molecular cellular changes that we are only just beginning to understand. hippocampus one the structures more closely related electrophysiological, structural morphological during ageing. In present study examined effect normal LPS-induced astroglia-neuron interaction rat adult, aged LPS-treated adult rats. Astrocytes were...
Epilepsy is one of the most common brain disorder and, despite possible use several therapeutic options, many patients continue to have seizures for their entire lifespan and they need new approaches. In last years interest on non-psychoactive compounds present in Cannabis sativa has massively increased, cannabidiol (CBD) been shown be effective treatment different types neurological disorders neurodegenerative diseases such as epilepsy, ischemia, multiple sclerosis Alzheimer's Disease.We...
Chronic cerebral hypoperfusion during aging may cause progressive neurodegeneration as ischemic conditions persist. Proper functioning of the interplay between neurons and glia is fundamental for functional organization brain. The aim our research was to study pathophysiological mechanisms, particularly derangement astrocytes-microglia with formation "triads," in a model chronic induced by two-vessel occlusion (2VO) adult Wistar rats (n = 15). protective effect dipyridamole given early...
Ischemia is a multifactorial pathology characterized by different events evolving in time. Immediately after the ischemic insult, primary brain damage due to massive increase of extracellular glutamate. Adenosine increases dramatically during ischemia concentrations able stimulate all its receptors, A1, A2A, A2B and A3. Although adenosine exerts clear neuroprotective effects through A1 receptors ischemia, use selective receptor agonists hampered their undesirable peripheral side effects. So...
We investigated the different patterns of neurodegeneration and glia activation in CA1 CA3 hippocampal areas TgCRND8 mice. The main feature this transgenic model is rapid development amyloid pathology, which starts already at 3 months age. performed immunohistochemical analyses to compare sensibility two regions neurodegeneration. qualitative quantitative evaluations by fluorescence immunohistochemistry with double or triple staining, followed confocal microscopy digital image analysis...
It is well accepted that sphingolipids play an important role in the pathological process of cerebral ischemia. In present study we have investigated involvement sphingosine 1-phosphate (S1P) pathway two different vitro models global organotypic hippocampal slices exposed to oxygen and glucose deprivation (OGD) evaluated mRNA expression S1P metabolic enzymes receptors (S1P1-5) by Real Time-PCR. same model effect inhibitor lyase (SPL), LX2931, selective antagonists S1P2, JTE-013, S1P3,...
(1) Background: Over the past 10 years, a number of scientific studies have demonstrated therapeutic potential cannabinoid compounds present in Cannabis Sativa and Indica plants. However, their role mechanisms leading to neurodegeneration following cerebral ischemia is yet unclear. (2) Methods: We investigated effects extracts (Bedrocan, FM2) or selected cannabinoids (Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabigerol) rat organotypic hippocampal slices exposed oxygen-glucose...
The hippocampus is negatively affected by aging and neurodegenerative diseases leading to impaired learning memory abilities. A diverse series of progressive modifications in the intercellular communication among neurons, astrocytes microglia occur during or inflammation. detailed understanding neurobiological that contribute hippocampal dysfunction may reveal new targets for therapeutic intervention. current study focussed on interplay between neurons astroglia Granule Layer (GL)...
Aging and neurodegenerative diseases share a condition of neuroinflammation entailing the production endogenous cell debris in CNS that must be removed by microglia (i.e., resident macrophages), to restore tissue homeostasis. In this context, extension microglial branches toward underlies mechanisms migration phagocytosis. Amoeboid morphology consequent loss branch functionality characterizes dysregulated microglia. Microglial is assisted another glial population, astroglia, which forms...
Cerebral ischemia is a multifactorial pathology characterized first by an acute injury, due to excitotoxicity, followed secondary brain injury that develops hours days after ischemia. During ischemia, adenosine acts as endogenous neuroprotectant. Few studies have investigated the role of A 2B receptor in because low potency for it and few selective ligands developed so far. receptors are scarcely but widely distributed on neurons, glial endothelial cells hematopoietic cells, lymphocytes...
Cannabinoids, used for centuries recreational and medical purposes, have potential therapeutic value in stroke treatment. Cannabidiol (CBD), a non-psychoactive compound partial agonist of TRPV2 channels, is efficacious many neurological disorders. We investigated the effects CBD or Δ9-tetrahydrocannabinol (THC) rat organotypic hippocampal slices exposed to oxygen-glucose deprivation (OGD), an vitro model ischemia. Neuronal expression decreased after OGD, but it increased activated,...
Brain photobiomodulation (PBM) is an innovative treatment for a variety of neurological conditions, including cerebral ischemia. However, the capability PBM ischemic stroke needs to be further explored and its mechanisms action remain currently unclear. The aim present research was identify protocol capable inducing neuroprotection investigate molecular activated by dual-wavelength near infrared (NIR) laser source in organotypic hippocampal slice model hypoxia/ischemia. Hippocampal slices...