A5078517744- Ovarian cancer diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Pancreatic function and diabetes
- Gut microbiota and health
- Bacillus and Francisella bacterial research
- Mitochondrial Function and Pathology
- Endometrial and Cervical Cancer Treatments
- DNA Repair Mechanisms
- ATP Synthase and ATPases Research
- Lung Cancer Treatments and Mutations
- Antimicrobial Peptides and Activities
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Sperm and Testicular Function
- Pancreatic and Hepatic Oncology Research
- Reproductive Biology and Fertility
- Cannabis and Cannabinoid Research
University of Ottawa
2017-2024
Ottawa Hospital
2017-2024
Ottawa Hospital Research Institute
2017-2024
The University of Texas MD Anderson Cancer Center
2020-2024
Western University
2012-2014
Metabolic reprogramming is a common phenomenon in cancers. Thus, glycolytic enzymes could be exploited to selectively target cancer cells therapy. Hexokinase 2 (HK2) converts glucose glucose-6-phosphate, the first committed step metabolism. Here, we demonstrated that HK2 was overexpressed ovarian and displayed significantly higher expression ascites metastatic foci. associated with advanced stage high-grade cancers, an independent prognostic factor. Functionally, knockdown of cell lines...
Abstract Early detection of ovarian cancer remains an important unmet medical need. Effective screening could reduce mortality by 10%–30%. Used individually, neither serum CA125 nor transvaginal sonography (TVS) is sufficiently sensitive or specific. Two-stage strategies have proven more effective, where a significant rise above woman's baseline prompts TVS and abnormal sonogram surgery. Two major trials documented that this strategy has adequate specificity, but sensitivity for early-stage...
Non-small cell lung cancer (NSCLC) is the leading cause of deaths primarily due to chemoresistance. Somatic mutation TP53 (36%) and epidermal growth factor receptor (EGFR; > 30%) are major contributors cisplatin (CDDP) resistance. Substantial evidence suggests elevated levels reactive oxygen species (ROS) a key determinant in cancer. The ROS can affect cellular responses chemotherapeutic treatments. Although role EGFR PI3K/Akt signaling cascade NSCLC extensively studied, molecular link...
The Normal Risk Ovarian Screening Study (NROSS) tested a two-stage screening strategy in postmenopausal women at conventional hereditary risk where significantly rising cancer antigen (CA)-125 prompted transvaginal sonography (TVS) and abnormal TVS surgery to detect ovarian cancer.
Abstract Background Multiple antigens, autoantibodies (AAb), and antigen-autoantibody (Ag-AAb) complexes were compared for their ability to complement CA125 early detection of ovarian cancer. Methods Twenty six biomarkers measured in a single panel sera from women with stage (I-II) cancers ( n = 64), late (III-IV) (186), benign pelvic masses (200) healthy controls (502), then split randomly (50:50) into training set identify the most promising classifier validation compare its performance...
Abstract Metabolic reprogramming (including the Warburg effect) is a hallmark of cancer, yet association between altered metabolism and chemoresistance remains elusive. Hexokinase II (HKII) key metabolic enzyme upregulated in multiple cancers. In this study, we examined impact targeting via silencing HKII on ovarian cancer (OVCA). addition, regulatory molecular mechanism tumor was using gain‐ loss‐of‐function approaches epithelial OVCA cell lines various histological subtypes. We...
The destiny of the ovarian follicle (growth or atresia) is tightly regulated by actions and interactions endocrine, paracrine, autocrine factors. Although androgens are known to be important in regulation folliculogenesis, whether they facilitate suppress follicular growth has been controversial, mechanisms involved not fully understood. Moreover, role androgen receptor (AR) mediating signaling during development clear. Here, we report that active dihydrotestosterone upregulates expression...
A recent ovarian cancer screening trial found no reduction in mortality, despite increased detection of early stage disease. Here, we discuss these findings and examine next steps to develop more effective approaches for the cancer.
Cellular adaptation to different stresses related survival and function has been demonstrated in several cell types. Anthrax lethal toxin (LeTx) induces rapid death, termed "pyroptosis," by activating NLRP1b/caspase-1 murine macrophages. We others (S. D. Ha et al., J. Biol. Chem. 282:26275-26283, 2007; I. Salles Proc. Natl. Acad. Sci. U. S. A. 100:12426 -12431, 2003) have shown that RAW264.7 cells preexposed sublethal doses of LeTx become resistant subsequent high cytolytic LeTx,...
Macrophages pre-exposed to a sublethal dose of anthrax lethal toxin (LeTx) are refractory subsequent high cytolytic doses LeTx, termed toxin-induced resistance (TIR). A small population TIR cells (2-4%) retains characteristics for up 5-6 wk. Through studying these long-term cells, we found that level histone deacetylase (HDAC)8 expression was crucial TIR. Knocking down or inhibition HDAC8 by interfering RNAs the HDAC8-specific inhibitor PCI-34051, respectively, induced mitochondrial death...
To assess the contributions of circulating metabolites for improving upon performance risk ovarian malignancy algorithm (ROMA) prediction cancer among women with cysts.
In epithelial ovarian cancer (EOC), carboplatin/cisplatin-induced chemoresistance is a major hurdle to successful treatment. Aerobic glycolysis common characteristic of cancer. However, the role glycolytic metabolism in and its impact on clinical outcomes EOC are not clear. Here, we show functional interaction between key enzyme hexokinase II (HKII) activated P-p53 (Ser15) regulation bioenergetics chemosensitivity. Using translational approaches with proximity ligation assessment cells human...
Mitochondrial dynamics (e.g. fission/fusion) play an important role in controlling chemoresistance representative gynecologic malignancies, ovarian and cervical cancer. Processing the long form of Optic atrophy (L-Opa)1 is a distinctive character mitochondrial fragmentation, associated with chemosensitivity. Here, we examined prohibitin (Phb)1 increasing L-Opa1 processing via regulating protease, Oma1 its direct interaction p-p53 (ser15) pro-apoptotic Bcl-2 antagonist/killer (Bak) 1...
5522 Background: The Normal Risk Ovarian Screening Study (NROSS) tested a two-stage screening strategy in post-menopausal women at conventional hereditary risk where significantly rising CA125 prompted transvaginal sonography (TVS) and abnormal TVS surgery to detect ovarian cancer. Methods: A total of 7,856 healthy postmenopausal were screened annually for 50,596 women-years single arm study ( NCT00539162 ). Serum was analyzed with the Cancer Algorithm (ROCA) each year. If normal <...
Supplementary Data from A Blood-Based Metabolite Panel for Distinguishing Ovarian Cancer Benign Pelvic Masses
Supplementary Figure from A Blood-Based Metabolite Panel for Distinguishing Ovarian Cancer Benign Pelvic Masses
Supplementary Figure from A Blood-Based Metabolite Panel for Distinguishing Ovarian Cancer Benign Pelvic Masses
Supplementary Figure from A Blood-Based Metabolite Panel for Distinguishing Ovarian Cancer Benign Pelvic Masses