A5061418660- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- BRCA gene mutations in cancer
- Prenatal Screening and Diagnostics
- Global Cancer Incidence and Screening
- Endometriosis Research and Treatment
- Genital Health and Disease
- Advances in Oncology and Radiotherapy
- Cancer survivorship and care
- Diversity and Career in Medicine
- Reproductive System and Pregnancy
- Glutathione Transferases and Polymorphisms
- Reconstructive Surgery and Microvascular Techniques
- Chemotherapy-induced organ toxicity mitigation
- Research in Cotton Cultivation
- Estrogen and related hormone effects
- Acute Lymphoblastic Leukemia research
- CRISPR and Genetic Engineering
- Family Support in Illness
- Urinary and Genital Oncology Studies
- Childhood Cancer Survivors' Quality of Life
- Neuroendocrine regulation and behavior
- Colorectal and Anal Carcinomas
The University of Texas at Austin
2017-2025
Medical College of Wisconsin
2023
DELL (United States)
2020
Baylor College of Medicine
2016-2019
Texas Children's Hospital
2014
The University of Texas Medical Branch at Galveston
2009-2013
Tulane University
2005
Agricultural Research Service
2002
Preeclampsia/eclampsia is a disorder of human pregnancy that continues to exact significant maternal morbidity and mortality fetal wastage. Therapy these disorders has not changed in over 50 years there are no proven preventive measures. We describe model the development syndrome pregnant rat resembles preeclampsia, which results from imposition excessive volume expansion early gestation. administered desoxycorticosterone acetate (DOCA) animals whose drinking water had been replaced with...
Context Development of optimal medicinal treatments uterine leiomyomas represents a significant challenge. 2-Methoxyestradiol (2ME) is an endogenous estrogen metabolite formed by sequential action CYP450s and catechol-O-methyltransferase (COMT). Our previous study demonstrated that 2ME potent antiproliferative, proapoptotic, antiangiogenic, collagen synthesis inhibitor in human cells (huLM). Objectives objectives were to investigate whether COMT expression, the virtue formation, affects...
What is known and objective Nephrotoxicity a recognized side effect of cisplatin chemotherapy. However, the optimal strategy for preventing cisplatin-induced nephrotoxicity, if any, remains unclear. The primary this study was to determine whether mannitol or furosemide provides better nephroprotection when administered with hydration prior weekly, low-dose concurrently whole pelvic radiotherapy. Methods Clinical data were abstracted from all women who underwent chemoradiation FIGO IB2-IVA...
Experts in gynecological cancer care recommend that all patients with invasive or high-grade ovarian (OC) undergo genetic testing. However, even who intend to take have taken tests many unaddressed information needs regarding Existing counseling falls short of adequately addressing this challenge.This study aims investigate the testing-related OC inform design interactive technology-based interventions can enhance communication testing patients.We interviewed 20 had and gathered messages...
Although cervical cancer is preventable, significant disparities exist in access to screening and prevention services. In medically underserved areas (MUAs) of Texas, these rates are 55% higher compared the remainder US. 2019, we expanded a multicomponent, comprehensive program improve partnership with 13 clinics mobile vans MUAs Texas. Our multicomponent intervention consists community education patient navigation coupled training/mentoring for local medical providers perform diagnostic...
(Abstracted from Gynecol Oncol 2024;183:85–92) The rate of gynecologic oncologists (GOs) experiencing burnout has increased in the United States since 2015, reflecting a nationwide trend across health care but intensified by stressors such as facing surgical complications and providing end-of-life care. Some most unique aspects GO practice, including longitudinal relationships, opportunities to offer complex care, availability ever-growing cancer therapeutics can be or sources secondary trauma.
5522 Background: The Normal Risk Ovarian Screening Study (NROSS) tested a two-stage screening strategy in post-menopausal women at conventional hereditary risk where significantly rising CA125 prompted transvaginal sonography (TVS) and abnormal TVS surgery to detect ovarian cancer. Methods: A total of 7,856 healthy postmenopausal were screened annually for 50,596 women-years single arm study ( NCT00539162 ). Serum was analyzed with the Cancer Algorithm (ROCA) each year. If normal <...
Abstract Knowledge of ovarian cancer patients' information practices around genetic testing (GT) is needed to inform interventions that promote patient access GT‐related information. We interviewed 21 patients and survivors who had GT as part the treatment process analyzed transcripts using qualitative content analysis method. found practices, manifested in their information‐seeking mode, sources utilized, assessment, use, showed three distinct styles: passive, semi‐active, active. Patients...
INTRODUCTION: To assess the role of routine endocervical curettage (ECC) and additional excisional biopsies (eg, top hat) performed with loop electrosurgical procedure (LEEP) in management severe cervical dysplasia. METHODS: Clinicopathologic data were abstracted from all patients who underwent LEEP for high grade dysplasia (CIN2-3) within a safety net health system between 2001 2013. Persistent disease was defined as uninterrupted abnormal cytology following LEEP, whereas recurrent ≥1 year...
Context: Development of optimal medicinal treatments uterine leiomyomas represents a significant challenge.2-Methoxyestradiol (2ME) is an endogenous estrogen metabolite formed by sequential action CYP450s and catechol-Omethyltransferase (COMT).Our previous study demonstrated that 2ME potent antiproliferative, proapoptotic, antiangiogenic, collagen synthesis inhibitor in human cells (huLM).Objectives: Our objectives were to investigate whether COMT expression, the virtue formation, affects...