A5016545677- Emotional Labor in Professions
- Statistical Methods in Clinical Trials
- Single-cell and spatial transcriptomics
- Parkinson's Disease Mechanisms and Treatments
- Andrographolide Research and Applications
- Consumer Retail Behavior Studies
- Radiomics and Machine Learning in Medical Imaging
- Birth, Development, and Health
- Head and Neck Cancer Studies
- Phytochemical compounds biological activities
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Berberine and alkaloids research
- Drug Transport and Resistance Mechanisms
- Molecular Biology Techniques and Applications
- Genetically Modified Organisms Research
- Folate and B Vitamins Research
- Evolutionary Psychology and Human Behavior
- Alkaloids: synthesis and pharmacology
- Advanced Biosensing Techniques and Applications
- Lung Cancer Treatments and Mutations
- Psychology of Moral and Emotional Judgment
- Political Influence and Corporate Strategies
- FinTech, Crowdfunding, Digital Finance
- Supply Chain Resilience and Risk Management
Southern Connecticut State University
2021-2024
Cardiovascular Institute of the South
2023
Yale University
2021-2022
Stony Brook School
2022
Sanofi (United States)
2019-2021
Massachusetts Institute of Technology
2008-2020
Wolfson Medical Center
2019
London Cancer
2018
Queen Mary University of London
2016-2017
Bentley University
2016
Abstract The progressive nature of Parkinson’s disease, its complex treatment regimens and the high rates comorbid conditions make self-management adherence a challenge. Clinicians have limited face-to-face consultation time with disease patients, making it difficult to comprehensively address non-adherence. Here we share results from multi-centre (seven centres) randomised controlled trial conducted in England Scotland assess impact using smartphone-based tracker app promote patient...
Immune checkpoint blockade elicits durable anti-cancer responses in the clinic, however a large proportion of patients do not benefit from treatment. Several mechanisms innate and acquired resistance to have been defined include mutations MHC I IFNγ signaling pathways. However, such occur low frequency additional yet be elucidated. In an effort better understand blockade, we generated mouse tumor model exhibiting vivo anti-PD-1 antibody MC38 tumors PD-1 following serial passaging. Lack...
Human lymphoblastoid cells derived from different healthy individuals display considerable variation in their transcription profiles. Here we show that such gene expression underlies interindividual susceptibility to DNA damaging agents. The results demonstrate the massive differences sensitivity across a diverse cell line panel exposed an alkylating agent. Computational models identified 48 genes with basal predicts 94% accuracy. Modulating transcript levels for two member genes, MYH and...
<h3>Importance</h3> The association of micronutrient supplementation during pregnancy with the intellectual development adolescent offspring is unknown. <h3>Objective</h3> To assess long-term antenatal development. <h3>Design, Setting, and Participants</h3> This 14-year follow-up study a randomized clinical trial in was conducted 2 counties rural western China 2118 (aged 10 to 14 years) mothers who were take daily capsule either folic acid, acid plus iron, or multiple micronutrients from...
Abstract KRas mutations are frequently seen in solid tumors such as lung (~25%), colorectal (~40%) and pancreatic (~90%) cancers. The G12C mutation accounts for ~50% of all cancer to a lower percentage other tumor types. Recently, selective inhibitors targeting the KRas-G12C through covalent link cysteine mutated protein have been advanced early clinical development exhibited encouraging response patients with cancer. Here, we present novel small molecule compound that specifically inhibits...
We investigated the ethnic differences in risk of several cancers population Nairobi, Kenya, using data from Nairobi Cancer Registry. The registry records variable “Tribe” for each case, a categorisation that includes, as well 22 tribal groups, categories Kenyans European and Asian origin, non‐Kenyan Africans. Tribes included final analysis were Kikuyu, Kamba, Kisii, Kalenjin, Luo, Luhya, Somalis, Asians, non‐Kenyans, Caucasians, Other tribes unknown. largest group was taken reference...
Generating social networks is essential for many applications, such as epidemic modeling and simulations. Prior approaches either involve deep learning models, which require observed training, or stylized are limited in their realism flexibility. In contrast, LLMs offer the potential zero-shot flexible network generation. However, two key questions are: (1) LLM's generated realistic, (2) what risks of bias, given importance demographics forming ties? To answer these questions, we develop...
Studies in Saccharomyces cerevisiae show that many proteins influence cellular survival upon exposure to DNA damaging agents. We hypothesized human orthologs of these S. would also be required for after treatment with For this purpose, homologs were identified and mapped onto the protein-protein interaction network. The resulting network was highly modular a series selection rules implemented identify 45 candidates toxicity-modulating proteins. corresponding transcripts targeted by RNA...
Andrographolide, a natural product, putatively functions through covalent inhibition of NF-κB, transcription factor that modulates tumor survival and metastasis. Previous studies found functionalization the C-19 hydroxyl alters primary mode action from NF-κB to modulation Wnt1/β-catenin signaling pathway. Here, we synthesized series trityl silyl ether analogs. MTT assays reveal cell line selectivity between colorectal breast cancer cells, which is consistent with known mechanisms...
Highly substituted pyridine scaffolds are found in many biologically active natural products and therapeutics. Accordingly, numerous complementary de novo approaches to obtain differentially pyridines have been disclosed. This article delineates the evolution of synthetic strategies designed assemble demanding tetrasubstituted core present limonoid alkaloids isolated from Xylocarpus granatum, including xylogranatopyridine B, granatumine A related congeners. The most efficient convergent...
Highly substituted pyridine scaffolds are found in many biologically active natural products and therapeutics. Accordingly, numerous complementary de novo approaches to obtain differentially pyridines have been disclosed. This article delineates the evolution of synthetic strategies designed assemble demanding tetrasubstituted core present limonoid alkaloids isolated from Xylocarpus granatum, including xylogranatopyridine B, granatumine A related congeners. The most efficient convergent...
From the seclusion of monastic life to noise Silicon Valley, ancient practice mindfulness has 'come out cloister.' As an antidote mindless cognition and behavior, — with its principle grounding attention in present moment been shown have powerful positive effects at both individual collective level fields as wide-ranging medicine, schooling, prison programs, law negotiation, business, even army. This installment Marketing & Technology introduces managers explores potential for enhancing...
Abstract Background Tusamitamab ravtansine is an antibody-drug conjugate of a humanized carcinoembryonic antigen (CEA)-related cell adhesion molecule 5 (CEACAM5)-specific monoclonal antibody linked to DM4. A Phase 1/2 study (NCT02187848) showed tusamitamab antitumor activity in pretreated patients (pts) with advanced nonsquamous NSCLC and high CEACAM5 expression. Here, we explore biomarker associations tumor expression by immunohistochemistry (IHC), whether biomarkers predict objective...
Introduction: Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that activate immunity against tumor cells but can cause immune related adverse events such as myocarditis, a rare serious side effect with up to 40% mortality. Hypothesis: Macrophages contribute recruitment of cytotoxic T-cell subsets the heart in setting ICI, causing myocarditis. Methods: To study role macrophage depletion on ICI we treated MRL/Pdcd1-/- mice liposomal clodronate. identify timing infiltration,...
ABSTRACT There is continuous debate regarding the impact of genetically modified (GM) products on human health and planet. The inconclusive nature scientific research concerning safety GM effect technology environment triggers further examination in this paper. This study evaluates positive negative impacts that foods have health. Effective testing regulation are key mechanisms to ensuring fit for humans free from adverse environmental effects. Keywords Genetic Engineering; Genetically...