A5026468961- Pneumonia and Respiratory Infections
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
- Pneumocystis jirovecii pneumonia detection and treatment
- Monoclonal and Polyclonal Antibodies Research
- Photodynamic Therapy Research Studies
- Tryptophan and brain disorders
- Helicobacter pylori-related gastroenterology studies
- Electrolyte and hormonal disorders
- Fungal Infections and Studies
- Respiratory viral infections research
- Antifungal resistance and susceptibility
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Neuropeptides and Animal Physiology
- Medical and Biological Ozone Research
- Retinoids in leukemia and cellular processes
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- Cancer Cells and Metastasis
- Pediatric health and respiratory diseases
- Glycosylation and Glycoproteins Research
BioNTech (Germany)
2021-2023
Jena University Hospital
2013-2017
Charité - Universitätsmedizin Berlin
2013
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2013
Friedrich Schiller University Jena
2013
University of Rostock
2010
Kiel University
1994
ABSTRACT The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis . pulmonary epithelium serves an important interface for interactions between these tract. Therefore, we analyzed expression pattern of in human lung. Immunohistochemically stained lung sections from 17 out 19 individuals were positive Dectin-1, which was apically bronchial alveolar...
Abstract Background The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung. They play a role innate adaptive immunity targets for various bacterial viral adhesins. Two pathogens that colonize the normally sterile lower respiratory tract patients with chronic obstructive pulmonary disease (COPD) non-typable Haemophilus influenzae (NTHI) Moraxella catarrhalis . Both bind to CEACAMs...
Immune checkpoint blockade elicits durable anti-cancer responses in the clinic, however a large proportion of patients do not benefit from treatment. Several mechanisms innate and acquired resistance to have been defined include mutations MHC I IFNγ signaling pathways. However, such occur low frequency additional yet be elucidated. In an effort better understand blockade, we generated mouse tumor model exhibiting vivo anti-PD-1 antibody MC38 tumors PD-1 following serial passaging. Lack...
Lower respiratory tract bacterial infections are characterized by neutrophilic inflammation in the airways. The carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 8 is expressed and released human granulocytes. Our study demonstrates that granulocytes release CEACAM8 response to DNA a TLR9-dependent manner. Individuals with high percentage of bronchial lavage fluid (BALF) were more likely have detectable levels BALF than those normal granulocyte count. Soluble, recombinant...
Candida albicans colonizes human mucosa, including the gastrointestinal tract, as a commensal. In immunocompromised patients, C. can breach intestinal epithelial barrier and cause fatal invasive infections. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1; CD66a), CEACAM5 (CEA), CEACAM6 (CD66c) are immunomodulatory receptors expressed on mucosa recruited by bacterial viral pathogens. Here we show for first time that fungal pathogen (i.e., albicans) also binds directly to...
The human restricted pathogen Moraxella catarrhalis is an important causal agent for exacerbations in chronic obstructive lung disease adults. In such patients, increased numbers of granulocytes are present the airways, which correlate with bacteria-induced and severity disease. Our study investigated whether interaction M. granulocyte-specific carcinoembryonic antigen-related cell adhesion molecule (CEACAM)-3 linked to NF-κB activation, resulting chemokine production. Granulocytes from...
Beyond its well-documented role in reproduction, embryogenesis and maintenance of body tissues, vitamin A has attracted considerable attention due to immunomodulatory effects on both the innate adaptive immune responses. In infectious diseases, been shown have a host-protective effect infections bacterial, viral or protozoan origin. Nevertheless, impact fungal remains unknown. Meanwhile, frequency invasive mycoses keeps growing, with Candida albicans being major opportunistic pathogen...
Chronic obstructive pulmonary disease (COPD) is complicated by infectious exacerbations with acute worsening of respiratory symptoms. Coinfections bacterial and viral pathogens are associated more severe exacerbations. Moraxella catarrhalis one the most frequent lower tract detected in COPD. We therefore studied impact M. on antiviral innate immune response that mediated via TLR3 p53. Molecular interactions between normal human bronchial epithelial (NHBE) cells as well Beas-2B were using...
Chronic lower airway inflammation is considered to be a major cause of pathogenesis and disease progression in chronic obstructive pulmonary (COPD). Moraxella catarrhalis COPD-associated pathogen causing exacerbations bacterial colonization the airways patients, which may contribute inflammation. Increasing evidence suggests that epidermal growth factor receptor (EGFR) modulates inflammatory processes human airways. The goal this study was investigate role EGFR M. catarrhalis-induced...
Helicobacter pylori infection is the most common cause of gastroduodenal ulcerations worldwide.Adaptation H. to acidic environment mediated by urease splitting urea into carbon dioxide and ammonia.Whereas neutralization acid ammonia essential for gastric colonization, catalytic activity nickel ions.Therefore, uptake metabolism play key roles in considered first line target drug development vaccination.Since binding within cells Histidine-rich protein designated Hpn, we investigated whether a...
The effect of renal function on cytokine secretion capacity mononuclear cells was analysed in patients who had not been subjected to any form replacement therapy. aim the study especially determine whether there is a defect monocyte function. were divided into three groups 12 basis function: group I, serum creatinine 1.5-3 mg/dl; II, 3-6 and III, > 6 mg/dl. Serving as controls 36 age- sex-matched healthy volunteers. IL-1 beta, IL-6, TNF-alpha, IL-2 IF-gamma concentrations measured...
Background We previously developed a saline-formulated mixture of 4 synthetic messenger ribonucleic acids (mRNAs) encoding the cytokines IL-12, IFN-α, GM-CSF, and IL-15 sushi (IL-15-IL-15Rα receptor fusion) that promoted systemic immunity tumor eradication upon intratumoral administration in multiple mouse models. Here, we explored whether stabilization mRNAs through lipoplex (LPX) formulation could confer increased expression encoded to result improved antitumor efficacy. To this end,...
Abstract Immune checkpoint blockade elicits durable anti-cancer responses in the clinic, however a large proportion of patients do not benefit from treatment. In an effort to better understand acquired resistance blockade, we generated mouse tumor model exhibiting vivo anti-PD-1 antibody MC38 tumors PD-1 following serial passaging. Lack sensitivity was attributed dysregulation PD-L1 or β2M expression, as both were expressed at similar levels parental and resistant cells. Similarly, IFNγ...