A5049362735- Muscle activation and electromyography studies
- Musculoskeletal pain and rehabilitation
- Transcranial Magnetic Stimulation Studies
- Spinal Cord Injury Research
- Motor Control and Adaptation
- Sports Performance and Training
- Pain Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Peripheral Nerve Disorders
- Stroke Rehabilitation and Recovery
- Sports injuries and prevention
- Pain Management and Treatment
- Spine and Intervertebral Disc Pathology
- Vestibular and auditory disorders
- Advanced Neuroimaging Techniques and Applications
- Nerve Injury and Rehabilitation
- Thermoregulation and physiological responses
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Thermal Regulation in Medicine
- Infrared Thermography in Medicine
- Pain Management and Placebo Effect
- Balance, Gait, and Falls Prevention
- Neuroendocrine regulation and behavior
- Ergonomics and Musculoskeletal Disorders
Imperial College London
2016-2025
Charing Cross Hospital
2007-2021
University of Miami
2018
ZNA Middelheim Hospital
2018
Australian Federation of Graduate Women New South Wales
2018
University Hospital of Wales
2018
King's College London
1996-2006
St Mary's Hospital
2005
This study was designed to investigate corticospinal excitability of lumbar muscles using transcranial magnetic stimulation (TMS) in patients with chronic low back pain and correlate this self-rated measures disability pain.Twenty-four 11 healthy control subjects were used study. TMS delivered through an angled double-cone coil, its cross-over on the vertex a posterior-to-anterior current flow brain. Electromyographic (EMG) recordings made from erector spinae (ES) at fourth level. Motor...
Several features of the surface electromyography (sEMG) signal are related to muscle activity and fatigue. However, time-evolution these non-stationary vary between subjects. The aim this study is investigate use adaptive algorithms forecast sEMG feature trunk muscles.Shallow models a deep convolutional neural network (CNN) were used simultaneously learn 5 common in real-time provide tailored predictions. This was investigated for: up 25 second horizon; for 14 different muscles trunk; across...
Many individuals with incomplete spinal cord injury (SCI) exhibit reduced volitional control of trunk muscles, such as impaired voluntary contractions the erector spinae (ES), due to damage neural pathways regulating sensorimotor function. Studies using conventional bipolar electromyography (EMG) showed alterations in overall, or global, activation muscles people SCI. However, how varied across specific regions within ES, referred regional activation, remains unknown. The aim study was...
Increases in activity of trunk muscles that occur prior to, or concurrent with, a voluntary limb movement are termed anticipatory postural adjustments (APAs). APAs important for maintaining stability response to perturbations but the neural mechanisms underlying remain unclear. Our results showed corticospinal excitability erector spinae (ES) muscle increased at 40 ms rapid shoulder flexion, with reduction intracortical inhibition and no change spinal excitability. Changes were observed ES,...
In anatomical education three-dimensional (3D) visualization technology allows for active and stereoscopic exploration of anatomy can easily be adopted into medical curricula along with traditional 3D teaching methods. However, most often knowledge is still assessed two-dimensional (2D) paper-and-pencil tests. To address the growing misalignment between learning assessment, this viewpoint commentary highlights development a virtual assessment scenario perspectives from students teachers on...
Evidence suggests that the primary motor cortex (M1) is involved in both voluntary, goal-directed movements and postural control. Trunk muscles are tasks, however, extent to which M1 controls these trunk flexion/extension (voluntary movement) rapid shoulder flexion (postural control) remains unclear. The purpose of this study was investigate question by examining excitability corticospinal inputs during voluntary tasks. Twenty healthy adults participated. Transcranial magnetic stimulation...
Oestradiol (E 2 ) has been shown to exacerbate the inhibitory effect of hypoglycaemic stress on gonadotrophin‐releasing hormone pulse generator (GnRH) activity in primates. The mechanism by which this is mediated not yet known. We therefore aimed establish whether there a sensitizing influence E suppression LH pulsatility response hypoglycaemia female rat, thus providing more amenable model study phenomenon. In ovariectomized Wistar rats with replacement, insulin‐induced (0.5 U/kg iv)...
Abstract Background Control of trunk movement relies on the integration between central neuronal circuits and peripheral skeletomuscular activities it can be altered by pain. There is increasing evidence that there are deficits within nervous system controlling muscles in people with low back pain ( LBP ). However, unclear how impacts upon neural drive to at different levels voluntary contraction. Therefore, purpose this study was investigate if impaired these patients. Methods Seventeen...
Anodal transcranial direct current stimulation over the primary cortex has been shown to activate regions of brain involved in descending modulation pain sensitivity. However, more research is required dissect spinal cord analgesic mechanisms associated with development central sensitization.In this randomized, double blind, crossover study 12 healthy participants had baseline mechanical stimulus response (S/R) functions measured before and after capsaicin-induced ongoing The effects 20 min...
Functional motor redundancy enables humans to move with distinct muscle activation patterns while achieving a similar outcome. Since select strategies, there seems be an optimal control. However, older adults differently young adults. The question is whether this due altered reinforcement scheme, sensory inputs, or alterations in the neuromusculoskeletal systems, so that it no longer possible execute same movement strategies. aim of study was analyse natural compensation strategies vital...
To establish intra- and inter-session reliability of high-density surface electromyography (HDEMG)-derived parameters from the thoracic erector spinae (ES) during static dynamic goal-directed voluntary movements trunk, functional reaching tasks.Twenty participants performed: 1) trunk extension, 2) forward lateral flexion, 3) multidirectional tasks on two occasions separated by 7.5 ± 1.2 days. Muscle activity was recorded bilaterally ES. Root mean square (RMS), coordinates barycentre,...
Muscle fatigue has high relevance in human performance yet little research evaluated how it should be assessed.To perform a pilot study to identify suitable methods of generating and assessing the trunk flexor extensor muscles.Sixteen university rugby players (mean (SEM) age 21.9 (0.2) years) were recruited subjected four protocols (A, B, C, D), separated by week allow recovery, with peak torque being recorded during each test: A, isokinetic measurements before after fatigue, 10 repetition...
People with chronic low back pain (LBP) exhibit changes in postural control. Stereotypical muscle activations resulting from external perturbations include anticipatory (APAs) and compensatory (CPAs) adjustments. The aim objective of this study was to determine differences control strategies (peak amplitude, APAs CPAs) between symptomatic asymptomatic adults without Lumbar Disc Degeneration (LDD) using surface electromyography during forward perturbation. Ninety-seven subjects participated...
The central regulation of the preovulatory LH surge requires a complex sequence interactions between neuronal systems that impinge on LH-releasing hormone (LHRH)-synthesizing neurons. reported absence estrogen receptors (ERs) in LHRH neurons indicates estrogen-receptive are afferent to involved mediating effects this steroid. We now present evidence indicating histaminergic neurons, exclusively located tuberomammillary caudal diencephalon, serve as an important relay system. Evaluation...