A5033723294- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Receptor Mechanisms and Effects
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Anesthesia and Neurotoxicity Research
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Pain Management and Opioid Use
- Pharmacogenetics and Drug Metabolism
- Child and Adolescent Psychosocial and Emotional Development
- Cancer, Stress, Anesthesia, and Immune Response
- Functional Brain Connectivity Studies
- Neural Networks and Reservoir Computing
- Cholinesterase and Neurodegenerative Diseases
- Advanced Memory and Neural Computing
- Optical Imaging and Spectroscopy Techniques
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Retinal Development and Disorders
- Alzheimer's disease research and treatments
Molloy College
2023
Marymount Manhattan College
2023
Rockefeller University
2012-2022
University of Minnesota Rochester
2008
Emory University
2003
The κ-opioid receptor (KOP-r) system and its endogenous ligands, the dynorphins, are involved in neurobiological regulation of addictive states, mood. There limited data on impact selective KOP-r antagonism humans basic biobehavioral functions, or diseases mood disorders. Previously studied antagonists have unusual pharmacodynamic pharmacokinetic properties (slow development selectivity, extremely long duration action) that limit translation to human studies. A recently developed...
Biased ligands preferentially activate certain signaling pathways downstream of their target receptor, leading to differential physiological or behavioral responses downstream. The kappa opioid receptor (KOR) is a drug for diseases involving mood and reward, such as depression addiction. KOR offer the potential overcome negative side effects that have previously hampered therapeutic development agonists by activating pathways. Understanding relationships between ligand bias behavior...
The kappa opioid receptor system has been revealed as a potential pharmacotherapeutic target for the treatment of addictions to substances abuse. Kappa agonists have shown block rewarding and dopamine-releasing effects psychostimulants. Recent investigations profiled in vivo compounds biased towards G-protein-mediated signaling, with less potent arrestin-mediated signaling. studied here derive from series trialkylamines: N-substituted-N- phenylethyl-N-3-hydroxyphenylethyl-amine,...
Abstract The biotransformation of the opioid peptide dynorphin A(1–17) was investigated in striatum freely moving Fischer rats, by direct infusion this peptide, followed recovery resulting products via microdialysis and identification using matrix‐assisted laser desorption/ionization mass spectrometry. observed peptides are consistent with enzymatic cleavage at Arg 7 ‐Ile 8 position A(1–17), terminal degradation A(1–7) A(8–17) peptides. Unexpectedly, novel post‐translational modifications...
Brief anesthesia, such as after exposure to high levels of carbon dioxide, prior decapitation is considered a more humane alternative for the euthanasia rodents, compared with use alone. Studies certain stress hormones in plasma corticosterone and ACTH have supported this method endocrinological molecular studies. In current study, rats were briefly exposed chamber filled dioxide until recumbent (20–25 sec), immediately killed via decapitation, trunk blood collected; findings no dioxide....
Numerous studies have investigated the behavioural effects of β‐endorphin, both endogenous and exogenously applied. However, potential for biotransformation β‐endorphin in extracellular space brain has not been previously directly addressed vivo . Utilising microinfusion/microdialysis matrix‐assisted laser desorption/ionisation mass spectrometry, we striatum rats. We infused 1.0 nmol into adult male Fischer rats observed rapid cleavage resulting 1–18, as well several fragments from further...
Selected Reaction Monitoring (SRM) is a method of choice for accurate quantitation low-abundance proteins in complex backgrounds. This strategy is, however, sensitive to interference from other components the sample that have same precursor and fragment masses as monitored transitions. We present here an approach detect by using expected relative intensity SRM also designed algorithm automatically linear range calibration curves. These approaches were applied experimental data Clinical...
This paper describes a second-generation one-time programmable read-only memory (OTPROM) that provides these features through balanced bitline, resistor pull-up, differential sense amp with reference.
Abstract The effect of increased tonicity on procaine-induced vacuolation in the H.Ep.2 cell has been investigated. An increase equivalent to about 1·3% NaCl was found reduce formation drug-induced vacuoles and also established vacuolation. There appeared be no difference effectiveness osmotic adjusting substances used (sodium chloride, sodium sulphate, glucose, fructose sucrose) when employed osmotically amounts.