A5101986497- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Olfactory and Sensory Function Studies
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Allergic Rhinitis and Sensitization
- Cancer-related gene regulation
- Nicotinic Acetylcholine Receptors Study
- Nanoplatforms for cancer theranostics
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Receptor Mechanisms and Signaling
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- Frailty in Older Adults
- Cancer, Stress, Anesthesia, and Immune Response
- Thermal Regulation in Medicine
- Respiratory and Cough-Related Research
- Anesthesia and Neurotoxicity Research
- Heme Oxygenase-1 and Carbon Monoxide
- Ear Surgery and Otitis Media
- Barrier Structure and Function Studies
- Genomics and Chromatin Dynamics
- Laser Applications in Dentistry and Medicine
- Pediatric health and respiratory diseases
Shenzhen Bay Laboratory
2023-2025
Huadong Hospital
2010-2022
Fudan University
2010-2022
Zhejiang A & F University
2022
Shanghai Medical College of Fudan University
2013
Abstract Upper airway diseases including sinonasal disorders may be caused by exposure to fine particulate matter (≤2.5 μm; PM2.5), as proven epidemiological studies. PM2.5 is a complex entity whose chemical constituents and physicochemical properties are not confined single, independent “particle” but which in this study means distinctive environmental “toxin.” The mechanism whereby induces nasal epithelial barrier dysfunction leading pathology remains unknown. In the present study, human...
Exposure to fine particulate matter (particulate ≤2.5 μm [PM2.5]) increases the risk of allergic rhinitis (AR), but underlying mechanisms remains unclear. Thus, we investigated roles T-helper (Th)1-Th2 cytokines and nasal remodeling after ambient PM2.5 exposure in a rat model AR.Female Sprague-Dawley rats were randomized into six groups: negative control group, group healthy exposed 3000 μg/m3 PM2.5, an ovalbumin (OVA) induced AR model, three PM2.5-exacerbated groups different concentrations...
Presbycusis (age-related hearing loss) is a potential risk factor for tinnitus and cognitive deterioration, which result in poor life quality. Presbycusis-related with impairment common phenotype the elderly population. In these subjects, central auditory system shows similar pathophysiological alterations as those observed Alzheimer's disease (AD), including cholinergic hypofunction, epileptiform-like network synchronization, chronic inflammation, reduced GABAergic inhibition neural...
Fried physical frailty, with mobility frailty and non-motor phenotypes, is a heterogeneous syndrome. The coexistence of the two phenotypes cognitive impairment referred to as (CF). It remains unknown whether phenotype has different association hearing loss (HL) tinnitus.Of 5,328 community-dwelling older adults, 429 participants aged ≥58 years were enrolled in study. divided into robust, mobility, non-mobility CF (subdivided reversible potentially CF, RCF, PRCF), decline [subdivided mild...
Abstract Aim To examine how the severity of age‐related hearing loss (ARHL) and tinnitus or presentation ARHL with is associated overall cognition, in terms specific cognitive domains older community‐dwelling Chinese adults. Methods The study recruited 429 participants aged ≥58 years (mean age, 72.91 ± 7.014 years; female proportion, 57.30%), excluding those dementia, disability, severe mental illness. Patients were classified into normal pre‐mild impairment (pre‐MCI), MCI according to...
Objective: To investigate the impact of severity age-related hearing loss (ARHL) and tinnitus, presence ARHL and/or physical frailty on health-related quality life (HRQoL) domain-specific HRQoL in Chinese community-dwelling older adults. Design: This was a cross-sectional study community-based cohort. Participants: We evaluated adults (n = 429, 183 men 246 women) aged ≥ 58years. Measurements: The HL tinnitus were measured using pure-tone audiometry Tinnitus Handicap Inventory (THI),...
Histone lysine methyltransferase SUV420H1, which is responsible for site-specific di-/tri-methylation of histone H4 20 (H4K20), has crucial roles in DNA-templated processes, including DNA replication, damage repair, and chromatin compaction. Its mutations frequently occur human cancers. Nucleosomes containing the variant H2A.Z enhance catalytic activities SUV420H1 on H4K20 di-methylation deposition, regulating early replication origins. However, molecular mechanism by specifically recognizes...
Ketamine is commonly used for sedation, analgesia and anesthetics, many evidences have shown that it has an immune-regulatory effect. The cholinergic anti-inflammatory pathway mediated by α7nAChR a prominent target of therapy. But whether ketamine suppresses inflammatory levels in nerve cells activating remains unknown. Lipopolysaccharide (LPS) was to establish the neuroinflammation model PC12 vitro, siRNA transfected into 30 min before LPS inhibit gene expression α7nAChR. were stimulated...
Objective:The aim of this study is to explore the characteristics ocular muscle vestibular evoked myogenic potential （oVEMP） in patients with Meniere's disease and benign paroxysmal positional vertigo （BPPV-MD）, clinical oVEMP frequency amplitude ratio （FAR）. Methods:Forty-one unilateral MD diagnosed outpatient clinic from January 2016 April 2019 were selected, which 15 BPPV-MD set as group, 26 group. During same period, 30 healthy volunteers matched age gender selected control All...