A5071629456- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Viral Infections and Vectors
- Microbial infections and disease research
- Poxvirus research and outbreaks
- Tumors and Oncological Cases
- Rabies epidemiology and control
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Agriculture and Farm Safety
- Prion Diseases and Protein Misfolding
- Mycobacterium research and diagnosis
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
Istituto Zooprofilattico Sperimentale della Sardegna
2013-2024
Abstract Lagovirus is an emerging genus of Caliciviridae , which includes the Rabbit Hemorrhagic Disease Virus (RHDV) rabbits and European brown hare syndrome virus (EBHSV) hares that cause lethal hepatitis. In 2010, a new RHDV related (RHDV2) with unique genetic antigenic profile lower virulence was identified in France rabbits. Here we report identification RHDV2 as Sardinia several outbreaks acute hepatitis Cape ( Lepus capensis mediterraneus ). This first account lagovirus causes fatal...
Orf virus (ORFV) is distributed worldwide and the causative agent of contagious ecthyma that mainly occurs in sheep goats. This disease was reported for first time at end 18th century Europe but very little currently known about temporal geographic origins this virus. In present study, use new Italian whole genomes allowed better inference on evolutionary history ORFV. accordance with previous studies, two genome types (S G) were described infection goats, respectively. These...
Canine herpesvirus 1 (CaHV-1) infects dogs, causing neonatal death and ocular, neurological, respiratory, reproductive problems in adults. Although CaHV-1 is widespread canine populations, only four studies have focused on the whole genome. In such context, two strains from both kidney spleen of 20-day-old deceased French Bulldog puppies were recently isolated Sardinia, Italy. The extracted viral DNA underwent whole-genome sequencing using Illumina MiSeq platform. Italian genomes nearly...
ORF virus (ORFV) causes contagious ecthyma (“ORF”), a disease of sheep and goats characterized by lesions ranging from vesicles pustules to atypical papilloma-like angiomatous in the skin mucosae. The authors investigated molecular factors leading ORF-associated tumor-like changes. Fifteen lambs, 15 kids, an adult ram clinically affected natural ORFV infection were enrolled study examined several methods. was detected viral culture or real-time polymerase chain reaction (RT-PCR) lesioned...
Orf virus (ORFV) represents the causative agent of contagious ecthyma, clinically characterized by mild papular and pustular to severe proliferative lesions, mainly occurring in sheep goats. In order provide hints on evolutionary history this virus, we carried out a study aimed assess genetic variation ORFV Sardinia that hosts large affected small ruminant population. We also found high worldwide mutational viral rate, which resulted, turn, higher than rate detected for strains isolated...
This paper reports that Bluetongue virus serotype 1 (BTV-1) infected blood collected during the 2006 Sardinia (Italy) epidemic from a ewe with clinical disease and stored at ~ 5°C for 10 years, caused (BT)-like death when inoculated into susceptible Sarda breed ram. Anatomo-histopathological examination Real-Time Reverse Transcriptase PCR (Real-Time RT-PCR) confirmed presence of BTV-1 in several tissues proving isolate has maintained its infectivity virulence.
Abstract Bluetongue disease (BT), caused by virus (BTV), infects wild and domestic ruminants, causing severe economic damage in the cattle sheep industry. Proven vectors of BTV are biting midges belonging to Culicoides genus, but other arthropods considered potential vectors, such as ticks, mosquitoes, wingless flies, sand flies. The present study represents first attempt evaluate vectorial capacity Culex pipiens Aedes albopictus for BTV. Mosquitoes were artificially fed with blood...
Abstract Most viral diseases display a variable clinical outcome due to differences in virus strain virulence and/or individual host susceptibility infection. Understanding the biological mechanisms differentiating infection displaying severe manifestations from its milder forms can provide intellectual framework toward therapies and early prognostic markers. This is especially true arbovirus infections, where most cases are present as mild febrile illness. Here, we used naturally occurring...
Most viral diseases display a variable clinical outcome due to differences in virus strain virulence and/or individual host susceptibility infection. Understanding the biological mechanisms differentiating infection displaying severe manifestations from its milder forms can provide intellectual framework toward therapies and early prognostic markers. This is especially true arbovirus infections, where most cases are present as mild febrile illness. Here, we used naturally occurring...
Using a multidisciplinary approach, this report describes clinical case of malignant catarrhal fever (MCF) occurring in calf, which shared the pasture with sheep on farm located island Sardinia (Italy). We confirmed conventional clinico-histopathological features MCF, as well was presence Ovine herpesvirus type 2 (OvHV-2) DNA several tissues, employing histological and virological investigations. The phylogenetic analysis revealed that Sardinian OvHV-2 strain is genetically similar to all...