A5007480658- Asymmetric Synthesis and Catalysis
- Diversity and Career in Medicine
- Synthesis and Biological Activity
- Peptidase Inhibition and Analysis
- Allergic Rhinitis and Sensitization
- Tryptophan and brain disorders
- Signaling Pathways in Disease
- Microbial Metabolism and Applications
- Mast cells and histamine
- Clinical Nutrition and Gastroenterology
- Mesenchymal stem cell research
- Political Economy and Marxism
- Global Cancer Incidence and Screening
- Dermatology and Skin Diseases
- Osteoarthritis Treatment and Mechanisms
- Synthetic Organic Chemistry Methods
- Nutrition and Health in Aging
- Microbial Natural Products and Biosynthesis
- COVID-19 and healthcare impacts
- Reconstructive Surgery and Microvascular Techniques
- Plant biochemistry and biosynthesis
- Neonatal Respiratory Health Research
- Oxidative Organic Chemistry Reactions
- Ethics and Legal Issues in Pediatric Healthcare
- Historical Gender and Feminism Studies
Duke Medical Center
2020-2024
Duke University
2021-2023
Emory University
2014-2022
Durham Technical Community College
2022
Texas Tech University Health Sciences Center
2022
Texas Tech University
2022
University Hospital of Wales
2001-2020
Winship Cancer Institute
2015-2016
Piedmont Cancer Institute
2015-2016
Boston Children's Hospital
2012-2015
Background Articular cartilage displays a poor repair capacity. The aim of cell-based therapies for defects is to damaged joint surfaces with functional replacement tissue. Currently, chondrocytes removed from healthy region the are used but they unable retain their phenotype in expanded culture. resulting tissue fibrocartilaginous rather than hyaline, potentially compromising long-term repair. Mesenchymal stem cells, particularly bone marrow stromal cells (BMSC), interest due inherent...
We have previously demonstrated that cryopreservation and thawing lead to altered Mesenchymal stromal cells (MSC) functionalities. Here, we further analyzed MSC's fitness post freeze-thaw. observed thawed MSC can suppress T-cell proliferation when separated from them by transwell membrane the effect is lost in a MSC:T-cell coculture system. Unlike actively growing MSCs, MSCs were lysed upon with activated autologous Peripheral Blood Mononuclear Cells (PBMCs) lysing was enhanced allogeneic...
Journal Article Reminiscing and Self-Concept in Old Age Get access Charles N. Lewis, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar of Gerontology, Volume 26, Issue 2, April 1971, Pages 240–243, https://doi.org/10.1093/geronj/26.2.240 Published: 01 1971
Atopic dermatitis (AD) skin lesions exhibit epidermal and dermal thickening, eosinophil infiltration, increased levels of the cysteinyl leukotriene (cys-LT) C 4 (LTC ). Epicutaneous sensitization with ovalbumin WT mice but not ΔdblGATA mice, latter which lack eosinophils, caused collagen deposition, mRNA expression cys-LT generating enzyme LTC synthase S). Skin thickening deposition were significantly reduced in ovalbumin-sensitized S-deficient type 2 receptor (CysLT R)–deficient 1...
The catabolism of tryptophan (Trp) by indoleamine 2,3-dioxygenase (IDO) is a key step in tolerance effected variety cell types, including mesenchymal stromal cells (MSCs). Trp generates molecules known as kynurenines, whose mechanisms involve activation the Aryl Hydrocarbon Receptor (AHR). A synthetic analog Trp, 1-methyl (1MT), selective inhibitor IDO enzymatic activity being utilized cancer immunotherapy trials. We hypothesized 1MT might activate AHR independently its effects on IDO....
Extracellular vesicles (EVs) from bone marrow (BM)-derived mesenchymal stromal cells (BM-MSC) are novel mechanisms of cell-cell communication over short and long distances. BM-MSC have been shown to support human antibody secreting (ASC) survival ex vivo, but whether the crosstalk between MSC-ASC interaction can occur via EVs is not known. Thus, we evaluated role in ASC IgG secretion. were isolated irradiated non-irradiated primary quantified. They further characterized by electron...
On July 3, 2014, the Organ Procurement and Transplantation Network (OPTN) began overseeing vascularized composite allotransplantation/allografts (VCA) in United States. For past 6 years, centers performing VCAs have been requested to submit data into a biometric repository, parallel with systems used by solid organ transplant centers. Currently, 62 are reported entire OPTN database, 36 of these transplants as performed after VCA was added Final Rule. Of recipients, 16 received uterus...
The reaction of N-methoxy-N-methylamides with the anion ethyl 2-methoxy- , or 2,4-dimethoxy-6-methylbenzoate gives corresponding ketones, which are cyclised to give 3-substituted 8-methoxy- and 6,8-dimethoxy-isocoumarins in good overall yield.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of dihydromevinolin and a series related 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitorsChristopher M. Blackwell, Alan H. Davidson, Steven B. Launchbury, Christopher N. Lewis, Elizabeth Morrice, Maxwell Reeve, Jonathon A. R. Roffey, Andrew S. Tipping, Richard ToddCite this: J. Org. Chem. 1992, 57, 21, 5596–5606Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October...
The Internal Revenue Service (IRS) and the University of Minnesota are conducting a multi-year study GDSS use in small group meetings. paper presents some initial findings on extent types uses that quality teams making IRS Manhattan District Office.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The biosynthesis of canescin (1), a metabolite Aspergillus malignus, has been studied using [Me13C2H3] methionine, sodium [1,2-13C2]- and [1-13C, 2-2H3]acetate, [2,3-13C2]- [2-13C, 2-2H2]-succinate as simple precursors, deuterium labelled isocoumarins potential advanced precursors. Analysis the products by both n.m.r. mass spectrometry suggests that 6,8-dihydroxy-3,7-dimethylisocoumarin (13) is first enzyme-free intermediate produced polyketide synthase,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn improved procedure for the introduction of .delta.-lactone portion HMG-CoA reductase inhibitorsChristopher M. Blackwell, Alan H. Davidson, Steven B. Launchbury, Christopher N. Lewis, Elizabeth Morrice, Maxwell Reeve, Jonathon A. R. Roffey, Andrew S. Tipping, and Richard ToddCite this: J. Org. Chem. 1992, 57, 6, 1935–1937Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March...
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