A5068789148- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Infections and Vaccines
- Fungal Infections and Studies
- Herpesvirus Infections and Treatments
- Nail Diseases and Treatments
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Toxoplasma gondii Research Studies
- Animal Virus Infections Studies
- Sepsis Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Vaccine Coverage and Hesitancy
- Neonatal and Maternal Infections
- Antibiotic Use and Resistance
- Tuberculosis Research and Epidemiology
- Cytokine Signaling Pathways and Interactions
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Renal Transplantation Outcomes and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
University of Helsinki
2010-2024
Helsinki University Hospital
2012-2024
Skaraborg Hospital
1987
Uppsala University Hospital
1987
Abstract Background No licensed human vaccines are available against enterotoxigenic Escherichia coli (ETEC), a major diarrhoeal pathogen affecting children in low- and middle-income countries foreign travellers alike. ETVAX®, multivalent oral whole-cell vaccine containing four inactivated ETEC strains the heat-labile enterotoxin B subunit (LTB), has proved promising Phase 1 1/ 2 studies. Methods We conducted 2b double-blinded, randomized, placebo-controlled trial amongst Finnish to Benin,...
In a population based epidemiological survey of juvenile chronic arthritis (JCA), performed in Western Sweden 1983, an incidence 12/100,000 was found. The estimated prevalence 56/100,000. Subgroup distribution showed preponderance mono- and pauciarticular forms. peak age onset between 0 4 years age. Girls predominated over boys ratio 3:2. Overall, 30% were antinuclear antibody (ANA) positive, 9% rheumatoid factor (RF) eye involvement occurred 10% the children. results suggest differences...
The performance of the interferon gamma release assays (IGRAs) and tuberculin skin test (TST) was reviewed retrospectively in patients with psoriasis, inflammatory musculoskeletal diseases, or miscellaneous conditions. study carried out over a 22-month period using 109 records psoriasis (), disease other conditions (). Forty-four (48%) were on immunosuppressive therapy 38/109 (35%) systemic glucocorticoid therapy. agreement between IGRAs substantial () whilst that TST low Logistic regression...
The risk of invasive pneumococcal disease is significant among solid organ transplant (SOT) recipients. optimal vaccination strategy for SOT patients not known.The potential kidney recipients in dialysis were randomized into two arms: to receive a 23-valent polysaccharide vaccine (PPV23) before transplantation or 13-valent conjugate (PCV13) and second dose PCV13 six months after the transplantation. Serotype-specific antibody concentrations opsonophagocytic activity (OPA) measured first...
Cytomegalovirus (CMV) remains an important pathogen in solid organ transplant patients.We executed a hybrid prophylactic and pre-emptive valganciclovir (VGCV) prophylaxis to prevent CMV infection heart patients with anti-thymocyte globulin (ATG) induction retrospectively evaluated the efficacy safety of this regimen.Hundred adult between 2004 2010 were included. Recipients serostatus D+/R- received VGCV 900 mg OD for 6 months 94.2% (81/86) R+ recipients low-dose 450 3 months. Blood was...
Cryptococcosis is one of the major causes mortality among HIV patients worldwide. Though most often associated with late stage infection/AIDS, a significant number cases occur in other immunocompromised such as solid organ transplant recipients and hematological malignancies. Immunocompromised are heterogeneous group their increases constantly. Since little known about incidence clinical features cryptococcosis Northern Europe, our aim was to investigate characteristics Finland.We...
Abstract Background Necrotizing myopathies and muscle necrosis can be caused by immune-mediated mechanisms, drugs, ischemia, infections, differential diagnosis may challenging. Case presentation We describe a case of diabetic myonecrosis complicated pyomyositis abscess Escherichia coli . A white woman in her late forties was admitted to the hospital with 1.5 week history bilateral swelling, weakness, mild pain lower extremities inability walk. She had type 1 diabetes retinopathy, neuropathy,...
Journal Article Efficacy and safety of cefpirome (FLR810) Get access S. R. Norrby, Norrby aDepartment Infectious Diseases, University UmeåUmeå Address for correspondence: Professor Ragnar Department Lasarettet, S-22185 Lund, Sweden Search other works by this author on: Oxford Academic PubMed Google Scholar L. Dotevall, Dotevall bDepartment Clinical Bacteriology, M. Eriksson, Eriksson B. Settergren, Settergren P. Larsson, Larsson cDepartment GothenburgGothenburg, Lundholm, Lundholm...
Abstract An outbreak of SARS-CoV-2 was confirmed after an academic party in Helsinki, Finland, 2022. All 70 guests were requested to fill follow-up questionnaires; serologic analyses and whole-genome sequencing (WGS) conducted when possible. Of those participating – all but one with ≥3 vaccine doses 21/53 (40%) had test-confirmed symptomatic COVID-19: 7% earlier episodes 76% without. Half (11/21) febrile, none needed hospitalisation. WGS revealed subvariant BA.2.23. Compared vaccination...