A5042445092- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Stress Responses and Cortisol
- Thyroid Disorders and Treatments
- Sexual Differentiation and Disorders
- Neuroblastoma Research and Treatments
- Pharmacological Effects of Natural Compounds
- COVID-19 Clinical Research Studies
- Pericarditis and Cardiac Tamponade
- Hormonal and reproductive studies
- Neuroendocrine Tumor Research Advances
- Diabetes and associated disorders
- Myasthenia Gravis and Thymoma
- Adrenal and Paraganglionic Tumors
- Thyroid Cancer Diagnosis and Treatment
- Diet and metabolism studies
- Bone health and treatments
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Chronic Disease Management Strategies
- Cancer, Hypoxia, and Metabolism
- Atrial Fibrillation Management and Outcomes
- Metabolism and Genetic Disorders
- Cardiac electrophysiology and arrhythmias
University of Cape Town
2015-2024
North Tees and Hartlepool NHS Foundation Trust
2024
Groote Schuur Hospital
2013-2023
Stellenbosch University
2022
Tygerberg Hospital
2022
Linköping University Hospital
1997
Aberdeen Royal Infirmary
1994
Valdimarsson T, Toss G, Ross I, Löfman O, Ström M. Bone mineral density in coeliac disease. Scand J Gastroenterol 1994;29:457-461.Patients with disease may have osteomalacia or osteoporosis, even the absence of abdominal symptoms. Little is known about effects a gluten-free diet and villous restitution on bone adult patients Of 288 our unit, 13 (5%) had persistent atrophy small bowel despite dietary recommendation over at least previous 4 years. For each these patients, 1 2 controls disease,...
Purpose Data on the prevalence of dyslipidaemia and associated risk factors in HIV-infected patients from sub-Saharan Africa is sparse. We performed a cross-sectional analysis cohort South African adults. Methods studied who were either antiretroviral therapy (ART)-naive or receiving non-nucleoside reverse transcriptase inhibitor (NNRTI)-based protease (PI)-based ART. Evaluation included fasting lipograms, oral glucose tolerance tests clinical anthropometry. Dyslipidemia was defined using...
We report a case of profound nephrogenic diabetes insipidus (NDI) in which renal resistance to antidiuretic hormone results dilute polyuria despite normal circulating concentrations. A 28-year-old man with bipolar mood disorder presented his local clinic symptoms suggestive lithium toxicity. Plasma concentrations and thyroid-stimulating (TSH) were taken, but not acted upon. One week later, he obtunded, severely dehydrated failure. His plasma concentration was 4.3 mmol/L (toxic threshold...
Patients with Addison’s disease (AD) have increased cardiovascular mortality. To study visceral fat and conventional exploratory risk factors in patients AD. A cross-sectional, single-center, case-control study. (n = 76; n 51 women) AD 76 healthy control subjects were matched for sex, age, body mass index (BMI), smoking habits. The primary outcome variable was abdominal adipose tissue (VAT) measured using computed tomography. Secondary variables prevalence of metabolic syndrome (MetS) 92...
COVID-19 outcomes and risk factors, including comorbidities medication regimens, in people living with diabetes (PLWD) are poorly defined for low- middle-income countries.
Background Information on clinical outcomes of coronavirus disease 19 (COVID-19) infection in patients with adrenal disorders is scarce. Methods A collaboration between the European Society Endocrinology (ESE) Rare Disease Committee and Reference Network Endocrine Conditions via Registries for allowed collection data 64 cases (57 insufficiency (AI), 7 Cushing’s syndrome) that had been reported by 12 centres 8 countries January 2020 December 2021. Results Of all patients, 23 were males 41...
Pericardial tuberculosis (TB) is associated with high therapy failure and mortality rates. Antibiotics have to penetrate site of infection at sufficient non-protein bound concentrations, then enter bacteria inhibit intracellular biochemical processes. The antibiotic concentrations achieved in pericardial fluid TB pericarditis never been measured before. We recruited two cohorts patients pericarditis, left a pigtail catheter in-situ for serial drug concentration measurements over 24 h....
Background Addison's disease is a potentially life-threatening disorder, and prompt diagnosis, introduction of steroid replacement has resulted in near normal life-expectancy. There are limited data describing the clinical presentation South Africa. It hypothesised that patients may present advanced state ill-health, compared to Western countries. Patients A national database was compiled from primary care, referral centres private practices. 148 were enrolled (97 white, 34 mixed ancestry, 5...
Patients with Addison's disease (AD) are believed to be at risk for cardiovascular (CVD). South Africa, like the rest of developing world is experiencing an increase in CVD and patients AD may double their peers. We wished explore patients' factors. A cross-sectional nationwide study Africa was conducted. cohort 147 healthy control subjects were matched by age, gender, ethnicity, BMI as far possible. Lipoproteins highly-sensitive C-reactive-protein (hs-CRP) main outcome measures. had...
Glucocorticoids have multiple therapeutic uses, but their impact on lipid metabolism and cardiovascular disease risk is not always considered during long-term treatment. Genetic variations, environmental factors the reasons for glucocorticoid treatment all influence profile atherosclerosis. Responses to may therefore be variable unpredictable. Despite frequency with which pharmacological doses of glucocorticoids are used, surprisingly few publications examine effects Patients managed should...
Background Patients with Addison's disease (AD) in Scandinavia have an increased risk for premature death due to cardiovascular (CVD). Serum lipids are important factors CVD and vascular mortality. Replacement doses of hydrocortisone historically been higher Sweden than South Africa. The primary aim was study the lipid profiles a large group patients AD hypothesis that profile would be worse Methods In cross-sectional study, 110 (55 from Africa, 55 Sweden) matched age, gender, ethnicity BMI...
OBJECTIVE--To determine whether serum myoglobin, creatine kinase, and kinase-MB measured at admission by rapid, compact, easy to use automated quantitative analysers (results within 10 min) helped the early identification of acute myocardial infarction. The results were compared with data obtained from electrocardiograms recorded admission. DESIGN--A prospective study. SETTING--Coronary care unit. PATIENTS--94 consecutive patients suspected Myocardial infarction was subsequently confirmed in...
The burden and management of primary adrenal insufficiency (PAI) in Africa have not been well documented. We aimed to identify specific disease characteristics, patient demographics, patterns clinical established PAI Africa.An online survey physicians' experience relating PAI.There were 1334 responses received, 589 complete, 332 respondents reported managing patients with hypoadrenalism. described related a calculated pool 5787 hypoadrenalism (2746 females, 3041 males), whom 2302 had PAI....
We sought to determine whether autoimmunity is the predominant cause of Addison's disease in South Africa and human leucocyte antigen (HLA) DQ association exists.We compiled a national registry patients from primary care, referral centres private practices.A total 144 patients, 94 European descent, 34 Mixed Ancestry, 5 Asian 11 Black Africans (mean age 45.9 years, range 2.7-88 years; mean duration 13.1 0-50 years) controls were matched for gender ethnicity. All potential causes...
Background Uncertainty exists whether glucocorticoid receptor (GCR) polymorphisms play a role in steroid-related side effects Addison's disease (AD) patients on hydrocortisone. The Bcl l and N363S appear to increase sensitivity cortisol, while the ER22/23EK polymorphism has been associated with resistance cortisol. Method One hundred forty seven AD patients, gender, ethnicity-matched controls were recruited South Africa. Three GCR studied, using PCR followed by restriction fragment length...
The watery diarrhoea, hypokalaemia and achlorhydria syndrome is a rare cause of secretory diarrhoea. In this case report, we highlight young female with as consequence vasoactive intestinal peptide producing composite adrenal phaeochromocytoma-ganglioneuroma. She made complete recovery after curative surgical resection.
Salivary cortisol has been used to monitor hydrocortisone replacement in patients with Addison's disease (AD). Since salivary is metabolised cortisone, it may be an adjunctive analyte assess adequacy of AD. We aimed characterise the exposure and cortisone healthy controls. measured by liquid chromatography-tandem mass spectrometry constructed a day curve (08:00 until 24:00 h) 16 time points 25 AD taking their usual dose 26 The median (interquartile range) area under (AUC) for was not...