A5032813658- Metabolism and Genetic Disorders
- Glycogen Storage Diseases and Myoclonus
- Diet and metabolism studies
- Corneal surgery and disorders
- Neurological and metabolic disorders
- Mitochondrial Function and Pathology
- Neonatal Health and Biochemistry
- Dermatological and Skeletal Disorders
- Biochemical and Molecular Research
- Lysosomal Storage Disorders Research
- Metabolomics and Mass Spectrometry Studies
- Connective tissue disorders research
- Biomedical Research and Pathophysiology
- Liver Disease Diagnosis and Treatment
- Carbohydrate Chemistry and Synthesis
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Blood disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Vasculitis and related conditions
- Genetic Neurodegenerative Diseases
- Amino Acid Enzymes and Metabolism
- Biliary and Gastrointestinal Fistulas
- Renal Diseases and Glomerulopathies
- Gallbladder and Bile Duct Disorders
North-West University
2011-2023
University of Pretoria
1986-2003
Tuberculosis meningitis (TBM) is the most severe form of extra-pulmonary tuberculosis and particularly intense in small children; there no universally accepted algorithm for diagnosis substantiation TB infection, which can lead to delayed intervention, a high risk factor morbidity mortality. In this study proton magnetic resonance (1H NMR)-based metabolomics analysis several chemometric methods were applied data generated from lumber cerebrospinal fluid (CSF) samples three experimental...
ABSTRACT Functional hypoxia is a stress condition caused by the abalone itself as result of increased muscle activity, which generally necessitates employment anaerobic metabolism if activity sustained for prolonged periods. With that being said, are highly reliant on to provide partial compensation energy production during oxygen-deprived episodes. However, current knowledge holistic metabolic response functional hypoxia, and contribution different pathways various tissues towards overall...
Benzoic acid is widely used as a preservative in food products and detoxified humans through glycine conjugation. Different viewpoints prevail on the physiological significance of conjugation reaction concerns have been raised potential public health consequences following uncontrolled benzoic ingestion. We performed metabolomics study which commercial containing flavored water vehicle for designed interventions, report here controlled consumption by 21 cases across 6 time points total 126...
Metabolomics studies of diseases associated with chronic alcohol consumption provide compelling evidence several perturbed metabolic pathways. Moreover, the holistic approach such gives insights into pathophysiological risk factors alcohol-induced disability, morbidity and mortality. Here, we report on a GC-MS-based organic acid profiling study acute consumption. Our investigation - involving 12 healthy, moderate-drinking young men simulated single binge drinking event, indicated its...
We sought to determine whether autoimmunity is the predominant cause of Addison's disease in South Africa and human leucocyte antigen (HLA) DQ association exists.We compiled a national registry patients from primary care, referral centres private practices.A total 144 patients, 94 European descent, 34 Mixed Ancestry, 5 Asian 11 Black Africans (mean age 45.9 years, range 2.7-88 years; mean duration 13.1 0-50 years) controls were matched for gender ethnicity. All potential causes...
Metabolomics studies of disease conditions related to chronic alcohol consumption provide compelling evidence several perturbed metabolic pathways underlying the pathophysiology alcoholism. The objective present study was utilize proton nuclear magnetic resonance (1H-NMR) spectroscopy metabolomics holistic consequences acute in humans. experimental design a cross-over intervention which included number substances be consumed—alcohol, nicotinamide adenine dinucleotide (NAD) supplement, and...
Abalone is currently considered South Africa's most successfully produced aquaculture export product, with a 76% share of the total value generated by sector. A major risk factor for this sector slow growth rates experienced during farming. feeds are often supplemented amino acids in an attempt to enhance abalone growth. This first investigation effect added proline standard feed, on metabolite profile slow-growing abalone. targeted liquid chromatography tandem mass spectrometry metabolomics...
Abstract: The objective was to determine the effect of combined antituberculosis (anti‐TB) drug therapy and an antioxidant, melatonin, on free radical organic acid profiles in experimental rat model. A anti‐TB drug, Rifater, consisting 12.0 mg rifampicin, 0.8 isoniazid, 23.0 pyrazinamide 18.56 μ g melatonin/kg body weight per day (corresponding average physiological human intake) were orally administered Sprague–Dawley rats. Hydroxyl production monitored by quantifying 2,3‐dihydroxybenzoic...
ALG6-CDG (formerly named CDG-Ic) (phenotype OMIM 603147, genotype 604566), is caused by defective endoplasmic reticulum α-1,3-glucosyltransferase (E.C 2.4.1.267) in the N-glycan assembly pathway (Grünewald et al. 2000). It second most frequent N-glycosylation disorder after PMM2-CDG; some 37 patients have been reported with 21 different ALG6 gene mutations (Haeuptle & Hennet 2009; Al-Owain 2010). We report on clinical and biochemical findings of five novel Caucasian South African patients....