A5103094088- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Dermatology and Skin Diseases
- Bacterial biofilms and quorum sensing
- Drug Transport and Resistance Mechanisms
- Antimicrobial agents and applications
- Pharmacological Effects of Natural Compounds
- Inflammatory mediators and NSAID effects
- RNA Interference and Gene Delivery
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Natural product bioactivities and synthesis
- Analytical Methods in Pharmaceuticals
- Essential Oils and Antimicrobial Activity
- Oral and gingival health research
- Nanoplatforms for cancer theranostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Protein Interaction Studies and Fluorescence Analysis
- Ginkgo biloba and Cashew Applications
- Proteins in Food Systems
- Botulinum Toxin and Related Neurological Disorders
- Genomics, phytochemicals, and oxidative stress
Kangwon National University
2020-2025
Nanyang Technological University
2017-2025
Chungnam National University
2010-2018
Nanyang Institute of Technology
2018
// Jong-Suep Baek 1 , Cheong-Weon Cho College of Pharmacy and Institute Drug Research Development, Chungnam National University, Yuseong-gu, Daejeon 34134, South Korea Correspondence to: Cho, email: chocw@cnu.ac.kr Keywords: solid lipid nanoparticle, multidrug resistance, p-glycoprotein, targeting delivery system, folate-mediated Received: January 20, 2017 Accepted: February 08, Published: March 13, 2017 ABSTRACT The objective the work was to develop a...
Purpose: Multi-walled carbon nanotubes (MWCNTs) were used as carriers for silver nanoparticles (AgNPs). In this process, MWCNTs coated with mesoporous silica (MWCNT-Silica) uniform and regular loading of AgNPs on the MWCNTs. addition, astaxanthin (AST) extract was a reducing agent ions to enhance antioxidant, antibiofilm, anticancer activities AgNPs. AST extracted from Haematococcus pluvialis (H. pluvialis) processed by hot melt extrusion (HME) content H. . has strong antioxidative...
While wogonin has been known to have cytotoxicity against various cancer cells, its bioavailability and are low due water solubility. Therefore, wogonin-loaded solid lipid nanoparticles were fabricated using a hot-melted evaporation technique. The highest solubility of was observed in stearic acid. Hence, composed acid as the matrix. physicochemical properties evaluated by dynamic laser scattering scanning electron microscopy. exhibited sustained controlled release up 72 h. In addition, it...
Methicillin-resistant Staphylococcus aureus (MRSA) is a significant concern for skin and soft tissue infections. Apart from biofilm formation, these bacteria can reside intracellularly in phagocytic nonphagocytic mammalian cells, complicating treatment with conventional antibiotics. Lipid-polymer hybrid nanoparticle (LPN) systems, combining the advantages of polymeric nanoparticles liposomes, represent new generation nanocarriers potential to address therapeutic challenges. In this study,...
The objective of this study was to evaluate the potential surface-modified paclitaxel (PTX)-incorporated solid lipid nanoparticles with hydroxypropyl-β-cyclodextrin (smPSH). smPSH released 89.70±3.99% its entrapped PTX within 24 h when placed in dissolution medium containing sodium lauryl sulfate. cellular uptake from Caco-2 cells 5.3-fold increased compared a solution based on Taxol formulation. Moreover, showed an cytotoxicity solution. In addition, AUC (5.43 µg•h/ml) and Cmax (1.44 µg/ml)...
Lipid-polymer hybrid nanoparticle enhances antibiotic efficacy through localised, sustained delivery to bacterial biofilms.
Abstract Objectives This study aimed to evaluate the potential of solid lipid nanoparticles (SLNs) paclitaxel (PTX) modified with a 2-hydroxypropyl-β-cyclodextrin system enhance cellular accumulation PTX into p-glycoprotein (p-gp)-expressing cells. Methods The PTX-loaded-SLNs consisted (stearic acid) and surfactants (lecithin poloxamer 188) were then by sonication method. Key findings In terms cytotoxicity, PTX-loaded SLNs showed higher cytotoxicity than other formulations. particular,...
Abstract: The World Health Organization (WHO) has reported that globally 235 million people suffer from chronic and other inflammatory diseases. short half-lives of nonsteroidal anti-inflammatory drugs (NSAIDs) their notoriety in causing gastrointestinal discomforts, warrants these to be released a controlled sustained manner. Although polymeric particles have been widely used for drug delivery, there are few reports showcase ability encapsulating sustaining the release NSAIDs. In this...
The aim of this work was to investigate the transdermal gel loaded with tadalafil, a practically insoluble selective phosphodiesterase-5 inhibitor (PDE5) in order improve solubility and bioavailability. tadalafil mixed solution hydroxypropyl-β-cyclodextrin (HPCD), polyethylene glycol (PEG) 400 tween 80 (T2 solution) 260.8 ± 4.3 µg/mL that modified T2 (M-T2) solution, which dissolved 20% (w/v) HPCD at first then mixture solutions PEG were added, increased 344.9 30.6 µg/mL. Four formulae...
Enterococcus faecalis (E. faecalis) biofilms are implicated in endocarditis, urinary tract infections, and biliary infections. Coupled with E. internalization into host cells, this opportunistic pathogen poses great challenges to conventional antibiotic therapy. The inability of ampicillin (Amp) eradicate bacteria hidden intracellular niches greatly reduces its efficacy against complicated To enhance the potency Amp different forms was loaded Lipid-Polymer hybrid Nanoparticles (LPNs), a...
KOB extracts are a polyherbal medicine had been prescribed for the treatment of hyperhydrosis and allergic diseases such as asthma rhinitis in oriental clinics. Therefore, pharmacokinetic studies extract administered orally to normal rats rhinitis-induced understand correlation efficacy plasma concentration patients future were performed. The study was conducted according administration pure baicalin rats, rats. Baicalin rat analyzed validated by HPLC analysis. interday precision based on...