A5058342762- Ginseng Biological Effects and Applications
- Immune Response and Inflammation
- Plant Toxicity and Pharmacological Properties
- Electrospun Nanofibers in Biomedical Applications
- Healthcare and Venom Research
- Veterinary Oncology Research
- Antimicrobial agents and applications
- Phytoestrogen effects and research
- Immunotoxicology and immune responses
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Nanomaterials in Catalysis
- Nanoparticles: synthesis and applications
- Ocular Surface and Contact Lens
- Pediatric health and respiratory diseases
- Bacterial Identification and Susceptibility Testing
- Vestibular and auditory disorders
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Congenital Heart Disease Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- biodegradable polymer synthesis and properties
- Diverse Topics in Contemporary Research
- Genomics, phytochemicals, and oxidative stress
- Heavy Metal Exposure and Toxicity
- Ginger and Zingiberaceae research
Korea Institute of Toxicology
2021-2025
Chungnam National University
2018-2022
Intratympanic (IT) therapies have been explored to address several side effects that could be caused by systemic administration of steroids treat inner ear diseases. For effective drug delivery the ear, an IT system was developed using poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) and thermosensitive gels maintain sustained release. Dexamethasone (DEX) used as a model drug. The size zeta potential PLGA NPs gelation time gel were measured. In vitro release studied Franz diffusion...
Abstract Background Gastric cancer (GC) is a common malignancy worldwide, with major attribution to Helicobacter pylori . Interleukin (IL)-17A has been reported be up-regulated in serum and tumor of GC patients, but the precise mechanisms underlying its involvement gastric tumorigenesis are yet established. Here, we investigated roles IL-17A pathogenesis H. -induced GC. Methods was induced knockout (KO) wild-type (WT) mice via N -methyl- -nitrosourea (MNU) treatment infection. At 50 weeks...
Abstract Cerium oxide nanoparticles (CeO 2 NPs, NM-212) are well-known for their catalytic properties and antioxidant potential, have many applications in various industries, drug delivery, cosmetic formulations. CeO NPs exhibit strong antimicrobial activity can be used to efficiently remove pathogens from different environments. However, knowledge of the toxicological evaluation is too limited support safe use. In this study, were orally administered Sprague Dawley rats 13 weeks at doses 0,...
The flavonoid myricetin is abundant in vegetables and has various bioactive properties, including anti-inflammatory antioxidative activities. In the present study, we explored effects of on alcohol-induced gastric ulcer a rat model. To induce ulcer, absolute ethanol (5 mL/kg body weight) was orally administrated to each rat. positive control myricetin-treated groups were given oral doses omeprazole (20 mg/kg) or (12 mg/kg), respectively, 1 hour prior administration alcohol. We found that...
Feline hypertrophic cardiomyopathy (HCM) is a common heart disease affecting 10–15% of all cats. Cats with HCM exhibit breathing difficulties, lethargy, and murmur; furthermore, feline can also result in sudden death. Among various methods indices, radiography ultrasound are the gold standards diagnosis HCM. However, only 75% accuracy has been achieved using alone. Therefore, we trained five residual architectures (ResNet50V2, ResNet152, InceptionResNetV2, MobileNetV2, Xception) 231...
Inhalation of polyhexamethylene guanidine phosphate (PHMG) can cause pulmonary fibrosis. Nicotinamide adenine dinucleotide (NADPH) oxidases (Nox) are enzymes that produce reactive oxygen species, which may be involved in tissue damage various lung diseases. To investigate whether the Nox2 isoform Nox is progression PHMG-induced damage, we studied contribution injury Nox2-deficient mice. We treated wild-type (WT) and knockout mice with a single intratracheal instillation 1.1 mg/kg PHMG...
Background. Chronic obstructive pulmonary disease (COPD) refers to a lung disorder associated with symptoms of dyspnea, cough, and sputum production. Traditionally, Yijin-tang (YJT), mixture Pinellia ternate, Poria cocos, ginger, Chinese liquorice, tangerine peel, has been prescribed for the treatment respiratory system diseases caused by dampness phlegm. This experiment investigated therapeutic effect YJT in mouse model cigarette smoke (CS)- lipopolysaccharide (LPS)-induced COPD. Methods....
Palmijihwanghwan (PJH) is a traditional medicine and eight constituents derived from PJH possess anti-inflammatory activities. However, the scientific evidence for its potential as therapeutic agent inflammatory lung disease has not yet been studied. In this study, we examined protective effect of in mouse model chronic obstructive pulmonary (COPD) induced by cigarette smoke (CS) with lipopolysaccharide (LPS).Mice received CS exposure 8 weeks intranasal instillation LPS on 1, 3, 5 7. (100...
Context Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung associated with respiratory symptoms and narrowing of airways. Gyeji-tang (GJT) traditional Asian medicine that has been used to relieve early-stage cold symptoms, headache, chills.Objective We examined the effect potential molecular action mechanism GJT in mouse model COPD induced by cigarette smoke (CS) plus lipopolysaccharide (LPS).Materials methods was C57BL/6J mice via daily exposure CS for 1 h 8 weeks...
Fatal systemic infection by Clostridium tarantellae in a wild Korean raccoon dog (Nyctereutes procyonoides koreensis) was diagnosed based on histopathology, immunofluorescence, PCR, and microbiome taxonomic profiling. Pathologic features were similar to Tyzzer's disease caused C. piliforme. This is the first report of dogs.
Abstract Background The long‐tailed macaque ( Macaca fascicularis ) is an Old World species, which one among the most commonly used monkeys for pharmaceutical research. However, of available background data are not suitable good laboratory practice (GLP)‐regulated drug safety tests because current reverence value covers fewer indices than necessary. Therefore, in this study, historical preclinical test were collected and managed. Methods Twenty‐five hematology, 20 clinical chemistry, 19...
A 5-year-old female lion-head rabbit weighing 2 kg was brought to a local animal hospital with hematuria. Radiography showed mass in the uterus, which removed by ovariohysterectomy. Macroscopic examination several masses both uterine horns. These masses, invaded deep walls, were firm touch, and their cut surfaces greyish-white color. Histopathologically, these nonencapsulated composed of spindle cells arranged cellular, large interlacing bundles or streams. The tumor had elongate nuclei...