A5087887825- Nerve injury and regeneration
- Spinal Cord Injury Research
- Signaling Pathways in Disease
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
- Neurological diseases and metabolism
- Calpain Protease Function and Regulation
- Spinal Hematomas and Complications
- Caveolin-1 and cellular processes
- Diet, Metabolism, and Disease
- Parkinson's Disease Mechanisms and Treatments
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- RNA modifications and cancer
- Cholesterol and Lipid Metabolism
- NF-κB Signaling Pathways
- Histone Deacetylase Inhibitors Research
Hasselt University
2018-2019
Universitat de Lleida
2006-2016
Biomedical Research Institute of Lleida
2007-2016
A disintegrin and metalloproteinase 17 (ADAM17) is the major sheddase involved in cleavage of a plethora cytokines, cytokine receptors growth factors, thereby playing substantial role inflammatory regenerative processes after central nervous system trauma. By making use hypomorphic ADAM17 knockin mouse model as well pharmacological ADAM10/ADAM17 inhibitors, we showed that ADAM17-deficiency or inhibition significantly increases clearance apoptotic cells, promotes axon improves functional...
In vivo and in vitro motoneuron survival depends on the support of neurotrophic factors. These factors activate signaling pathways related to cell or inactivate proteins involved neuronal death. present work, we analyzed involvement nuclear factor-κB (NF-κB) pathway mediating mouse spinal cord promoted by This comprises ubiquitously expressed transcription that could be activated two different routes: canonical pathway, associated with IKKα/IKKβ kinase phosphorylation translocation RelA...
Intracellular calcium (Ca(2+)) concentration determines neuronal dependence on neurotrophic factors (NTFs) and susceptibility to cell death. Ca(2+) overload induces death the consequences are thought be a probable cause of motoneuron (MN) degeneration in neurodegenerative diseases. In present study, we show that membrane depolarization with elevated extracellular potassium (K(+)) was toxic cultured embryonic mouse spinal cord MNs even presence NTFs. Membrane induced an intracellular...
After spinal cord injury (SCI), monocyte derived macrophages play a detrimental role.Histone deacetylases (HDACs) are central epigenetic regulators of macrophage-polarization.We hypothesized that HDAC3 inhibition suppresses the pro-inflammatory macrophage phenotype (M1), promotes anti-inflammatory (M2) and improves functional recovery after SCI.Therefore, two inhibitors were selected, namely scriptaid RGFP966.The impact on polarization was studied by investigating effect gene protein...
Abstract Smith-Lemli-Opitz syndrome (SLOS) is a rare disorder of cholesterol synthesis. Affected individuals exhibit growth failure, intellectual disability and broad spectrum developmental malformations. Among them, renal agenesis or hypoplasia, decreased innervation the gut, ptosis are consistent with impaired Ret signaling. receptor tyrosine kinase that achieves full activity when recruited to lipid rafts. Mice mutant for born no kidneys enteric neurons, display sympathetic nervous system...