A5016581055- Surfactants and Colloidal Systems
- Protein Interaction Studies and Fluorescence Analysis
- Ionic liquids properties and applications
- Photochemistry and Electron Transfer Studies
- Drug Transport and Resistance Mechanisms
- Analytical Chemistry and Chromatography
- Spectroscopy and Quantum Chemical Studies
- Chemical and Physical Properties in Aqueous Solutions
- Protein Structure and Dynamics
- Metal-Catalyzed Oxygenation Mechanisms
- Vanadium and Halogenation Chemistry
- Metal complexes synthesis and properties
- Polymer Surface Interaction Studies
- Antibiotics Pharmacokinetics and Efficacy
- Thermodynamic properties of mixtures
- Lipid Membrane Structure and Behavior
- Enzyme Structure and Function
- Molecular Sensors and Ion Detection
- Synthesis and properties of polymers
Jamia Millia Islamia
2014-2022
University of Delhi
2018-2021
TIFR Centre for Interdisciplinary Sciences
2017
The present work is a brief overview of the effect psychostimulant drug mephedrone hydrochloride (4MMC) on transport protein, bovine serum albumin (BSA). binding 4MMC BSA has been investigated by using UV-visible, steady-state fluorescence, time-resolved fluorescence resonance energy transfer, Fourier transform infrared, circular dichroism, and molecular docking method. 4-Methylmephedrone quenched intrinsic static quenching mechanism, which was further confirmed fluorescence. absorption...
Herein, we are reporting the interaction of ionic liquid type gemini surfactant, 1,4-bis(3-dodecylimidazolium-1-yl) butane bromide ([C12-4-C12 im]Br2) with lysozyme by using Steady state fluorescence, UV-visible, Time resolved Fourier transform-infrared (FT-IR) spectroscopy techniques in combination molecular modeling and docking method. The steady fluorescence spectra suggested that was quenched [C12-4-C12 im]Br2 through static quenching mechanism as confirmed time spectroscopy. binding...
Protein interactions with surfactants are dependent on their physiochemical properties.
Herein, the binding of 1-methyl-3-octylimidazolium chloride [OMIM][Cl] ionic liquid with hen egg white lysozyme (HEWL) has been studied using fluorescence, time resolved UV-visible and circular dichroism (CD) spectroscopy, in combination computational study. The fluorescence results revealed that quenches fluorophore HEWL through static quenching mechanism. calculated thermodynamic parameters show bind hydrophobic interactions. In addition, negative value Gibbs energy change (∆G) indicates...
Abstract The thermodynamics of mixed micellization amitriptyline hydrochloride (AMT) with ionic liquid‐type imidazolium gemini surfactant ([C 10 ‐4‐C im] Br 2 ), was investigated at different mole fractions and temperatures by surface tension measurements. deviation the critical micelle concentration (CMC) from ideal (CMC * micellar fraction ( ) values interaction parameter activity coefficients (for both micelles monolayer) explained non‐ideal behavior (i.e., synergistic behavior) binary...
The interactions of imidazolium bashed ionic liquid-type cationic gemini surfactant ([C12-4-C12im]Br2) with HSA were studied by fluorescence, time-resolved UV-visible, circular dichroism, molecular docking and dynamic simulation methods. results showed that the [C12-4-C12im]Br2 quenched fluorescence through quenching mechanism as confirmed spectroscopy. Stern-Volmer constant (Ksv) relevant thermodynamic parameters such enthalpy change (ΔH), Gibbs free energy (ΔG) entropy (ΔS) for interaction...
Bovine serum albumin (BSA) is one of the most abundant albumins in plasma. This class protein plays a vital role transportation variety exogenous and endogenous substances s...
Abstract To get an idea about the pharmacokinetics and pharmacodynamics, it is important to study drug‐protein interaction. Therefore, herein, we studied interaction of diclofenac sodium (DIC) with human hemoglobin. The binding nonsteroidal antiinflammatory drug, DIC hemoglobin (HHB) was done by utilizing fluorescence, UV–visible, time‐resolved fluorescence far‐UV circular dichroism spectroscopy (CD). Various thermodynamic parameters such as enthalpy change ( ΔH ), entropy ΔS Gibbs free...
The mixed micellization behavior of amitriptyline hydrochloride (AMT) with cetyltrimethylammonium bromide (CTAB) has been studied at different mole fractions in the presence imidazolium based ionic liquid 1-butyl-3-methyl (Bmim·Cl), by using electrical conductivity temperatures from 298 to 318 K. A shift Tmax value (i.e., temperature which cmc is maximized) observed rise CTAB fraction. Synergistic interaction explained deviations critical micelle concentration (cmc) an ideal (cmc*) and...
Abstract We investigated the interaction of diclofenac sodium (Dic.Na) with bovine serum albumin (BSA) in absence and presence urea using different spectroscopic techniques. A fluorescence quenching study revealed that Stern–Volmer constant decreases urea, decreasing further at higher concentrations. The binding number sites were also evaluated for BSA–Dic.Na system a modified equation. is greater high concentrations, as shown by results. In addition, system, static mechanism was observed,...
Herein, we have studied the micellization of imidazolium-based ionic liquid type gemini surfactant ([C12-4-C12im]Br2) in absence and presence aromatic amino acids by conductivity surface tension measurements at different temperatures (i.e., 298, 308, 318 K). Various interfacial parameters, that is, Gibbs excess (Γmax), minimum head group area air/water interface (Amin), thermodynamic free energy micellization/adsorption (), standard entropy enthalpy () were evaluated for all systems. The...
Herein, we discuss various physicochemical properties of cationic (CTAB), anionic (SDBS) and nonionic (TX-100) surfactants in the presence absence lysozyme, at different temperatures by using tensiometery. The surface excess (Γmax) decreases with increase temperature for all three kinds but most prominent decrease is to be observed SDBS as compared CTAB TX-100 lysozyme. minimum area per molecule (Amin) follows opposite trend expected. In addition, contact angle analysis was also done observe...