A5088300809- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Cholesterol and Lipid Metabolism
- Peptidase Inhibition and Analysis
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Immune Response and Inflammation
- Ion channel regulation and function
- Helicobacter pylori-related gastroenterology studies
- Alcohol Consumption and Health Effects
- Adenosine and Purinergic Signaling
- Reproductive tract infections research
- Asthma and respiratory diseases
- Cancer, Hypoxia, and Metabolism
- Neonatal and Maternal Infections
- Peroxisome Proliferator-Activated Receptors
- Complement system in diseases
- Metabolism and Genetic Disorders
- Lipid metabolism and biosynthesis
- Lipid metabolism and disorders
- Drug Transport and Resistance Mechanisms
- Diet, Metabolism, and Disease
Medizinische Hochschule Brandenburg Theodor Fontane
2017-2024
Brandenburg University of Technology Cottbus-Senftenberg
2021-2024
University of Potsdam
2021-2024
Charité - Universitätsmedizin Berlin
2014-2023
Klinikum Brandenburg
2023
Humboldt-Universität zu Berlin
2007-2022
Freie Universität Berlin
2018-2022
German Institute of Human Nutrition
2021
Max Delbrück Center
2014-2017
DRK Kliniken Berlin
2015
Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are the precursors of potent lipid mediators play an important role in regulation inflammation. Generally, n-6 PUFA promote inflammation whereas n-3 have antiinflammatory properties, traditionally attributed to their ability inhibit formation PUFA-derived proinflammatory eicosanoids. Newly discovered resolvins protectins derived directly from with distinct pathways action. However, tissue status these has not been addressed....
Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA) contribute to the regulation cardiovascular function. CYP enzymes also accept EPA and DHA yield more potent vasodilatory potentially anti-arrhythmic metabolites, suggesting that endogenous CYP-eicosanoid profile can be favorably shifted by dietary omega-3 fatty acids. To test this hypothesis, 20 healthy volunteers were treated with an EPA/DHA supplement analyzed for concomitant changes in circulatory urinary levels AA-,...
Cytokines such as tumor necrosis factor alpha (TNF-alpha) are key factors in liver inflammation. Supplementation with essential omega-3 polyunsaturated fatty acids (n-3 PUFA) has been demonstrated to lower TNF-alpha and IL-1 production mononuclear cells. An inflammation-dampening effect observed increased acid supplementation several inflammatory diseases. In this study, we used the transgenic fat-1 mouse, expressing a Caenorhabditis elegans desaturase endogenously forming n-3 PUFA from n-6...
Background: Colonic microbiome is thought to be involved in auto-immune multiple sclerosis (MS). Interactions between diet and the colonic MS are unknown. Methods: We compared composition of microbiota quantitatively 25 patients 14 healthy controls.Fluorescence situ hybridization (FISH) with 162 ribosomal RNA derived bacterial FISH probes was used. Ten received a ketogenic for 6 months. Changes concentrations 35 numerically substantial groups were monitored at baseline 2, 12, 23/24 weeks....
Liver tumors, particularly hepatocellular carcinoma (HCC), are a major cause of morbidity and mortality worldwide. The development HCC is mostly associated with chronic inflammatory liver disease various etiologies. Previous studies have shown that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) dampen inflammation in the decrease formation tumor necrosis factor (TNF)-α. In this study, we used fat-1 transgenic mouse model, which endogenously forms n-3 PUFA from n-6 to determine effect an...
Malnutrition is a common problem in oncological diseases, influencing treatment outcomes, complications, quality of life and survival. The potential role malnutrition has not yet been studied systematically neuroendocrine neoplasms (NEN), which, due to their growing prevalence additional therapeutic options, provide an increasing clinical challenge diagnosis management. aim this cross-sectional observational study, which included long-term follow-up, was therefore define the 203 patients...
Colorectal cancer (CRC) is the second leading cause of deaths in USA. Anti-inflammatory drugs were shown to be effective prevention CRC, supporting a link between inflammation and tumorigenesis colon. However, due their side effects, long-term administration these for CRC not feasible. An increased tissue content omega-3 polyunsaturated fatty acids (n-3 PUFA) can dampen colon animals as well humans. Whether increasing n-3 PUFA alone preventing remains investigated. Here we show that...
Volume regulation is essential for normal cell function. A key component of the cells' response to volume changes activation a channel, which elicits characteristic chloride currents (ICl, Swell). The molecular identity this channel has been controversial. Most recently, ClC-3, protein highly homologous ClC-4 and ClC-5 proteins, proposed as being responsible ICl, Swell (1Duan D. Winter C. Cowley S. Hume J.R. Horowitz B. Nature. 1997; 390: 417-421Crossref PubMed Scopus (412) Google Scholar)....
There is a large body of experimental evidence suggesting that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are capable modulating immune function. Some studies have shown these PUFAs might beneficial effect in patients suffering form multiple sclerosis (MS), chronic inflammatory demyelinating disease the central nervous system (CNS). This could be due to increased n-3 PUFA-derived anti-inflammatory lipid mediators. In present study we tested an endogenously PUFA status on...
Long-chain n-3 polyunsaturated fatty acid (PUFA) supplementation has shown potential benefits in the prevention of coronary heart disease (CHD); however, impact omega-3 levels on CHD risk remains a subject debate. Here, we aimed to investigate association between PUFA and CHD, with particular reference subtypes PUFA. Methods: Prospective studies retrospective case-control analyzing published up 30 July 2022, were selected. A random effects meta-analysis was used for pooled assessment,...
Abstract Although early detection and treatment of colorectal cancer (CRC) have improved, it remains a significant health‐care problem with high morbidity mortality. Data indicate that long‐term intake low‐dose aspirin reduces the risk CRC; however, mechanisms underlying this chemopreventive effect are still unclear. Different mouse models for inflammation‐associated, sporadic, hereditary CRC were applied to assess efficacy mechanism on tumor prevention. An initial dosing study performed in...