A5042241512- Neuroendocrine Tumor Research Advances
- Clinical Nutrition and Gastroenterology
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Nutrition and Health in Aging
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Body Composition Measurement Techniques
- Electrolyte and hormonal disorders
- Gestational Trophoblastic Disease Studies
- Child Nutrition and Feeding Issues
- Pancreatic and Hepatic Oncology Research
- Childhood Cancer Survivors' Quality of Life
- Abdominal Surgery and Complications
- Enhanced Recovery After Surgery
- Health and Medical Studies
- Metastasis and carcinoma case studies
- Brain Metastases and Treatment
- Child Nutrition and Water Access
- Electrostatic Discharge in Electronics
- Therapeutic Uses of Natural Elements
- Cancer, Stress, Anesthesia, and Immune Response
- Pancreatic function and diabetes
- Intestinal and Peritoneal Adhesions
- Diabetes Treatment and Management
Asklepios Klinik St. Georg
2019-2025
Asklepios Kliniken Hamburg
2022
Semmelweis University
2022
Charité - Universitätsmedizin Berlin
2011-2020
MSH Medical School Hamburg – University of Applied Sciences and Medical University
2019-2020
Humboldt-Universität zu Berlin
2018
European Neuroendocrine Tumor Society
2018
Freie Universität Berlin
2018
DRK Kliniken Berlin
2015
Malnutrition is a common problem in oncological diseases, influencing treatment outcomes, complications, quality of life and survival. The potential role malnutrition has not yet been studied systematically neuroendocrine neoplasms (NEN), which, due to their growing prevalence additional therapeutic options, provide an increasing clinical challenge diagnosis management. aim this cross-sectional observational study, which included long-term follow-up, was therefore define the 203 patients...
Pulsed-field ablation (PFA) yields a novel technology for atrial fibrillation (AF). PFA lesions promise to be highly durable, however clinical data on lesion characteristics are still limited.This study sought investigate creation with ultrahigh-density (UHDx) mapping.Consecutive AF patients underwent PFA-based pulmonary vein isolation (PVI) using multispline catheter (Farwave, Farapulse Inc.). Additional ablation, including left posterior wall (LAPWI) and mitral isthmus (MI) were performed...
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare malignancies deriving from the endocrine system in gastrointestinal tract including pancreas. Prognosis is greatly heterogenous due to its dependency on various factors, most importantly stage and differentiation. Several studies report an alarming rise incidence past decade. Despite there being some therapeutical options, best therapy sequence still needs be defined, particularly for unresectable and/or intermediate...
Abstract Background Parenteral nutrition (PN) is a life‐sustaining therapy for patients with chronic intestinal failure (IF) but inevitably has an impact on patients’ quality of life (QoL). The purpose this study was to examine multiple aspects QoL by utilizing the standardized Short Form 36 (SF‐36) health survey. Methods Between 2014 and 2017, total 90 adult IF who were receiving PN prospectively enrolled in observational study. All subjects underwent status assessment, liver blood tests,...
<b>Hintergrund:</b> Neuroendokrine Tumoren (NET) des Verdauungstrakts sind seltene und heterogene Tumoren. Die Erhebung valider Daten zu Epidemiologie, Diagnostik, Therapie, Prognose Risikofaktoren ist das Ziel deutschen NET-Registers. <b>Patienten/Methode:</b> Das deutsche NET-Register erfasst bundesweit die histologisch gesicherter NET-Patienten. Der hier dargestellte Erfassungszeitraum umfasst Zeit von 1999 bis 2010 wird seit 2004 prospektiv fortgeführt. <b>Ergebnisse:</b> 2009 Patienten...
The glucagon-like peptide-2 (GLP-2) analogue teduglutide is a medical treatment option for patients with short-bowel syndrome-associated chronic intestinal failure. Because studies in mice have shown that GLP-2 analogues may promote the growth of colonic neoplasms, surveillance colonoscopies before and during therapy were recommended. occurrence small-intestinal neoplasms has not been reported so far, except recent report about de novo development hamartomatous duodenal polyps. We case...
Although gastric neuroendocrine neoplasias (gNEN) are an orphan disease, their incidence is rising. The heterogeneous clinical course powers the ongoing discussion of most appropriate classification system and management. Prognostic relevance proposed classifications was retrospectively analysed in 142 patients from a single tertiary referral centre. Baseline, management survival data were acquired for statistical analyses. distribution according to clinicopathological typification gNEN-1 (n...
Liver abnormalities in intestinal failure (IF) patients receiving parenteral nutrition (PN) can progress undetected by standard laboratory tests to associated liver disease (IFALD). The aim of this longitudinal study is evaluate the ability non-invasive function assess following initiation PN. Twenty adult with IF were prospectively included at PN and received scheduled follow-up assessments after 6, 12, 24 months between 2014 2019. Each visit assessment (LiMAx [Liver Maximum Capacity] test,...
Neuroendocrine neoplasia grade 3 (NEN G3) represents a rare and heterogeneous cancer type with poor prognosis. The aim of our study was to analyze real-world data from the German NET Registry focus on therapeutic prognostic aspects.
4095 Background: Global European high quality epidemiologic data on Neuroendocrine Neoplasms (NEN) are lacking. There is limited knowledge the contribution of prognostic factors patient (pt) management. Methods: The multinational ENETS registry (www.enets.org/the_registry.html) was launched in 2015. To date, from 7 countries (Belgium, Czech republic, Germany, Greece, Poland, Spain, Switzerland) were analyzed, including age, gender, primary site, functional syndrome, WHO grade, stage...
Lymph node (LN) involvement in gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) has been reported to have prognostic and therapeutic implications. Numerous novel LN classifications exist; however, no comparison of their performance for GEP-NEN done yet. Using a nationwide cohort from the German Neuroendocrine Tumor (NET) Registry, discriminatory power different ratio (LNR) log odds metastatic (LODDS) were investigated using multivariate Cox regression C-statistics 671 patients with...
The human intestinal tract reacts to extensive resection with spontaneous adaptation. We analyzed whether gene expression analyses or permeability (IP) testing could provide biomarkers describe regulation mechanisms in the barrier short bowel syndrome (SBS) patients during adaptive response treatment glucagon-like peptide-2 analog teduglutide.Relevant regions of GLP-2 receptor were sequenced. Gene and immunohistochemistry performed from mucosal biopsies. IP was assessed using a carbohydrate...
Was ist neu? Anatomische und funktionelle Klassifikation Das chronische Darmversagen (CVD) bei Kurzdarmsyndrom (KDS) wird sowohl durch die postoperative Anatomie als auch funktionell anhand des parenteralen Kalorien- Volumenbedarfs klassifiziert. Spontane intestinale Adaptation Die Anpassungsreaktion nach Darmresektion verläuft in 3 Phasen, jeweils eines interdisziplinären Managements bedürfen. Therapie chronischen Darmversagens Ziel der eine ausreichende Nährstoffversorgung unter Vermeidung...
Zusammenfassung Neuroendokrine Neoplasien (NEN) umfassen eine seltene Tumorentität mit heterogener Biologie, Prognose und therapeutischen Optionen. In Zusammenhang der kürzlichen Publikation ersten deutschen Leitlinie zur Diagnostik Therapie von NEN erfolgte die Analyse Kohorte des Deutschen NET-Registers Gesellschaft für Endokrinologie (DGE). Hierzu wurden 2686 Fälle extrahiert ihre Patientencharakteristika wie Alter, Geschlecht, Primärtumorlokalisation, Grading Staging dargestellt sowie...