Brian J. Levine

ORCID: 0000-0002-5371-4037
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About
Contact & Profiles
Research Areas
  • Antimicrobial Resistance in Staphylococcus
  • Diabetes Management and Research
  • Bacterial Identification and Susceptibility Testing
  • Diabetes Treatment and Management
  • Sleep and Wakefulness Research
  • Diabetes Management and Education
  • Acute Kidney Injury Research
  • Sleep and related disorders
  • Sepsis Diagnosis and Treatment
  • Central Venous Catheters and Hemodialysis
  • Healthcare Decision-Making and Restraints
  • Clostridium difficile and Clostridium perfringens research
  • Sleep and Work-Related Fatigue
  • Mobile Health and mHealth Applications
  • Emergency and Acute Care Studies
  • Pancreatic function and diabetes
  • Antibiotics Pharmacokinetics and Efficacy
  • Facial Trauma and Fracture Management
  • Clinical practice guidelines implementation
  • Traumatic Ocular and Foreign Body Injuries
  • Cardiac Imaging and Diagnostics
  • Intensive Care Unit Cognitive Disorders
  • Ultrasound in Clinical Applications
  • Nursing Roles and Practices
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients

Close Concerns (United States)
2017-2021

University of San Francisco
2020

Christiana Care Health System
2007-2019

Williams College
2018

Jefferson College
2014

Morristown Medical Center
2012-2013

Thomas Jefferson University
2000

Henry Ford Hospital
1987-1988

The daytime sleepiness of a large sample (n = 129) healthy, young (age 18-29) adults with no sleep-wake complaints was measured and compared that 47) older 30-80) normal sleeping, subjects. Each spent 8 h in the laboratory on 1 night received Multiple Sleep Latency Test (MSLT) following day. latency at 1000, 1200, 1400, 1600 h. Mean sleep ranged from 2 to 20 min within each group, but shape distribution between groups different. mean subjects (particularly college students) shorter than...

10.1093/sleep/11.1.39 article EN SLEEP 1988-01-01

IN BRIEF After assessing patient perspectives on the success of current diabetes therapies and factors that have greatest impact daily life, we show time-in-range is a crucial outcome for people with are falling short this metric. We also patients feel significant stress worry, they believe in diet, exercise, weight maintenance. In addition, diet exercise in-range blood glucose biggest drivers improved management mindset. Together, these findings support need improve outcomes including beyond A1C.

10.2337/cd17-0094 article EN cc-by-nc-nd Clinical Diabetes 2017-12-28

To characterize emergency department sedation practices in mechanically ventilated patients, and test the hypothesis that deep is associated with worse outcomes.Multicenter, prospective cohort study.The ICUs of 15 medical centers.Mechanically adult patients.None.All data involving (medications, monitoring) were recorded. Deep was defined as Richmond Agitation-Sedation Scale -3 to -5 or Sedation-Agitation 2 1. A total 324 patients studied. Emergency observed 171 (52.8%), a higher frequency...

10.1097/ccm.0000000000003928 article EN Critical Care Medicine 2019-08-08

C‐peptide is a cleavage product that comes from processing proinsulin to insulin induces nitric oxide (NO) ‐mediated vasodilation. NO modulates leukocyte‐endothelium interaction. We hypothesized might inhibit interaction via increased release of endothelial NO. Using intravital microscopy the rat mesentery, we measured leukocyte‐ endothelium interactions after administration rat. Superfusion mesentery with either thrombin or L‐NAME consistently and significantly number rolling, adhering,...

10.1096/fj.00-0183com article EN The FASEB Journal 2000-11-01

Optimizing vancomycin dosing may help eradicate bacteria while avoiding resistance. The guidelines recommend loading doses; however, there are no data to demonstrate that this result in a more rapid achievement of therapeutic troughs.To evaluate the percentage troughs reaching levels at 12, 24, and 36 hours following an initial dose 30 mg/kg compared with 15 mg/kg.This prospective, randomized study was performed community academic medical center. Patients who were receive emergency...

10.1177/1060028014556813 article EN Annals of Pharmacotherapy 2014-10-30

IN BRIEF Given the progressive nature of type 2 diabetes, treatment intensification is usually necessary to maintain glycemic control. However, for a variety reasons, often not intensified in timely manner. The combined use basal insulin and glucagon-like peptide-1 receptor agonist recognized provide complementary approach diabetes. This review evaluates efficacy safety two co-formulation products, degludec/liraglutide glargine/lixisenatide, diabetes inadequately controlled on either...

10.2337/cd17-0093 article EN cc-by-nc-nd Clinical Diabetes 2018-01-11

This study employed a repeated measures design to assess the relationship between sleep efficiency and time-in-bed (TIB). Fourteen subjects underwent three TIB conditions: (5 hour, 8 11 hour), which were presented in Latin Square design. Subjects slept total of six nights (two per condition) while being monitored by wrist actigraph determine time. Sleep efficiencies (sleep time/TIB) analyzed with two-way repeated-measures ANOVA. The main effect night was not significant. interaction In...

10.3109/00207458808986162 article EN International Journal of Neuroscience 1988-01-01

Patients with a low risk of coronary artery disease (CAD) presenting to the emergency department (ED) chest pain pose diagnostic dilemma because small percentage will suffer an acute myocardial infarction (MI) and sudden death. The authors conducted this study determine whether exercise stress echocardiography (ESE) could be used further support safe discharge these low-risk patients.A convenience sample patients > or =30 years age without prior cardiac history who presented academic...

10.1111/j.1553-2712.2001.tb01290.x article EN Academic Emergency Medicine 2001-02-01

Objective Vancomycin loading doses are recommended; however, the risk of nephrotoxicity with these is unknown. The primary objective this study was to compare in emergency department (ED) sepsis patients who received vancomycin at high (>20 mg/kg) versus lower (≤20 mg/kg). Methods A retrospective cohort performed three academic EDs. Inclusion criteria were age ≥ 18 years, intravenous order, and hospital admission. Exclusion no documented weight, hemodialysis-dependent, inadequate serum...

10.1111/acem.12934 article EN Academic Emergency Medicine 2016-02-06

It has been proposed that telehealth may help to combat the epidemic of diabetes and other chronic diseases in US. As a result rapid technological advancement over past decade, there an explosion virtual management program offerings rooted smartphone technology, connected devices for blood glucose monitoring, remote coaching or support. Such take many forms with unique features. We provide care team-based classification system programs highlight their strengths limitations. also include...

10.1038/s41746-020-00313-3 article EN cc-by npj Digital Medicine 2020-08-07

To the best of our knowledge, there are no published data on historical and recent use CGM in clinical trials pharmacological agents used treatment diabetes. We analyzed 2,032 40 antihyperglycemic therapies currently market with a study start date between 1 January 2000 31 December 2019. According to ClinicalTrials.gov, 119 (5.9%) these CGM. usage has increased over time, rising from <5% before 2005 12.5% However, it is still low given its inclusion American Diabetes Association's latest...

10.2337/cd20-0049 article EN Clinical Diabetes 2021-01-22
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