A5062760245- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Birth, Development, and Health
- Transplantation: Methods and Outcomes
- Salivary Gland Disorders and Functions
- Gestational Diabetes Research and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Immunotherapy and Immune Responses
- Cardiovascular Conditions and Treatments
- Oral microbiology and periodontitis research
- Neurofibromatosis and Schwannoma Cases
- Protein Degradation and Inhibitors
- Radiology practices and education
- Cardiac Arrhythmias and Treatments
- Connective tissue disorders research
- Organ and Tissue Transplantation Research
- Ocular Disorders and Treatments
- Cardiac and Coronary Surgery Techniques
- Organ Donation and Transplantation
- Retinopathy of Prematurity Studies
All India Institute of Medical Sciences
2014-2024
Albert Einstein College of Medicine
2014-2023
Montefiore Medical Center
2014-2023
All India Institute of Medical Sciences, Deoghar
2021-2022
Vinoba Bhave University
2018-2019
Uttaranchal University
2018
California University of Pennsylvania
2017
University of Pennsylvania
2009-2014
Florida College
2011
University of Florida
2011
The Clinical Islet Transplantation 07 (CIT07) protocol uses antithymocyte globulin and etanercept induction, islet culture, heparinization, intensive insulin therapy with the same low-dose tacrolimus sirolimus maintenance immunosuppression as in Edmonton protocol. To determine whether CIT07 improves engrafted β-cell mass, our center measured secretory capacity from glucose-potentiated arginine tests at days 75 365 after transplantation compared those results previously achieved by group...
Asthma is an obstructive airway disease characterized by inflammation.To measure systemic inflammation in asthma patients, and to assess the effect of treatment on inflammation.In 30 newly diagnosed non-randomized adult patients we measured markers (serum high-sensitivity C-reactive protein, total leukocyte count, erythrocyte sedimentation rate) before after a 6-week standard with inhaled steroids β(2) agonist. The comparison group comprised 20 healthy control subjects. All subjects were...
Abstract A major obstacle to transplantation tolerance is humoral immunity. In this paper, we demonstrate that the intrinsic developmental propensity of B lymphocyte compartment for acquisition self-tolerance can be harnessed induce unresponsiveness transplanted alloantigens. current study, when transitional cells developed in presence donor lymphoid cells, mature failed mount a donor-specific alloantibody response an organ transplant—despite unrestrained acute T cell-mediated allograft...
Immunologic rejection is a major barrier to successful long-term outcomes in clinical transplantation. The importance of B lymphocytes-and their secretory products, alloantibodies-in the pathogenesis allograft accepted. Furthermore, it now clear that dominant regulator peripheral B-cell homeostasis and tolerance B-lymphocyte stimulator (BLyS), also referred as activating factor (BAFF). Recently, novel class immunotherapeutic agents specific for BLyS, its family cytokines, has emerged...
Redfield RR, Parsons RF, Rodriguez E, Mustafa M, Cassuto J, Vivek K, Noorchashm H, Naji A, Levine MH, Abt PL. Underutilization of A2 ABO incompatible kidney transplantation. Clin Transplant 2011 DOI: 10.1111/j.1399‐0012.2011.01543.x. © John Wiley & Sons A/S. Abstract: Background: compatibility creates a disadvantage for O and B renal allograft candidates. transplant may decrease waiting times generate equivalent graft survival to an compatible transplant. Methods: Death‐censored was...
T lymphocytes are the primary targets of immunotherapy in clinical transplantation; however, B-lymphocytes and their secreted alloantibodies also highly detrimental to allograft. Therefore, achievement sustained organ transplant survival will likely require induction B-lymphocyte tolerance. During development, acquisition B-cell tolerance self-antigens relies on clonal deletion early stages compartment ontogeny. We contend that this mechanism should be recapitulated setting alloantigens...
Coloboma as an ocular finding has been documented in various syndromes. Here we have a case of infantile Tay-Sachs disease associated with unilateral choroidal coloboma. To the best our knowledge, such association not literature. Whether is matter chance or signifies involvement ganglioside metabolism embryogenesis remains to be elucidated.
Nonhuman primates are the closest animal models to humans with respect genetics and physiology. Consequently, a critical component of immunogenetics research relies on drawing inferences from cynomolgus macaque inform human trials. Despite conserved organization Major Histocompatibility Complex (MHC) between macaques humans, MHC genotyping is challenging due high rates copy number variants, duplications, rearrangements, particularly at class I loci. Furthermore, limited availability...
The present objective was to assess the phytochemical and in vitro antioxidant properties of Ehretia laevis ethyl acetate extract. Antioxidant activity measured using DPPH standard technique followed by purification a solvent gradient based column TLC. positive fractions were analyzed gas chromatography technique. It discovered that chloroform more elute than hexane 22 distinct systems. Elution fraction with water alone showed poor fractionation no scavenging potential. Chloroform methanol...
A 38-year-old female with a past history of pheochromocytoma and subsequent malignant paraganglioma presented right arm pain after fall. Imaging demonstrated malunited humeral shaft associated large cortical destructive lesion extraosseous extension. Here, we report the use multidisciplinary team approach including an endocrinologist, anesthesiologist, orthopedic surgeon in perioperative management patient metastatic undergoing surgical resection humerus, internal fixation, reconstruction,...