A5079726166- Neurotransmitter Receptor Influence on Behavior
- HIV, Drug Use, Sexual Risk
- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Receptor Mechanisms and Signaling
- Sex work and related issues
- Pharmaceutical Practices and Patient Outcomes
- Diabetes and associated disorders
- Alzheimer's disease research and treatments
- Nicotinic Acetylcholine Receptors Study
- Pain Management and Opioid Use
- Liver physiology and pathology
- HIV-related health complications and treatments
- Platelet Disorders and Treatments
- Hepatitis B Virus Studies
- Neuropeptides and Animal Physiology
- Mitochondrial Function and Pathology
- Cardiac Arrest and Resuscitation
- Lipid metabolism and biosynthesis
- Amino Acid Enzymes and Metabolism
- Dementia and Cognitive Impairment Research
University of Alberta
2025
NHS Greater Glasgow and Clyde
2019-2024
Neuropsychiatric Research Institute
2000
University of California, Los Angeles
1987-1997
Alcohol Research Group
1987
Neurobehavioral Systems
1987
Primary and secondary antibody deficiencies (PAD SAD) are amongst the most prevalent immunodeficiency syndromes, often necessitating long-term immune globulin replacement therapy (IRT). Both intravenous immunoglobulin (IVIG) subcutaneous (SCIG) have demonstrated efficacy in deficiency. Comparative analyses of these two routes administration limited to nurse-administered IVIG home with self-administered SCIG. A third programmatic approach, SCIG administered by nurses hospital-based outpatient...
Objective To investigate the association between opioid replacement therapy (ORT) and benzodiazepine (BZD) coprescription all-cause mortality compared with prescription of ORT alone. Design Population-based cohort study. Setting Scotland, UK. Participants were people prescribed January 2010 end December 2020 aged 18 years or above. Main outcome measures All-cause mortality, drug-related deaths non-drug related deaths. Secondary continuous treatment duration. Analysis Cox regression...
Tais epidemic of exanthematous disease complicated by purulent infection the bronchi attacked several lhundred inen belonging to a recent draft from New Zealand; 418 cases measles and rubella occurred between January 1st March 8th, 1918.In large majority there was copious frothy or muco-purulent bronchorrhoea, in 75 them was. severe bronclhitis, these 26 died.If we take into consideration only
Drug-related deaths (DRDs) in Scotland increased for seven years a row between 2014 and 2020, consolidating Scotland's place at the top of United Kingdom European drug-related mortality charts. One defining features this recent rapid rise has been role benzodiazepines, which are now involved majority all DRDs. These linked to use non-prescribed, benzodiazepine-type novel psychoactive substances (NPS) have identified by Nations as global threat public health. This study aimed estimate...
Abstract An outbreak of human immunodeficiency virus (HIV) among people who inject drugs in Glasgow, Scotland started 2014. We describe 156 cases over 5 years and evaluate the impact clinical interventions using virological phylogenetic analysis. established (1) HIV services within homeless health facilities, including outreach nurses, (2) antiretroviral therapy (ART) via community pharmacies. Implementation new model reduced time to ART initiation from 264 23 days increased viral load...
Abstract Objectives Our aim was to examine mortality trends in the era of antiretroviral therapy, among people who inject drugs (PWID) are living with HIV. The study objectives were assess and quantify PWID diagnosed HIV over time Scotland, context a recent outbreak rise drug‐related mortality. Methods This retrospective cohort those Scotland between January 2000 February 2020, acquisition related injecting drug use, linked data. Factors associated all‐cause examined using Cox proportional...
Summary Alleles of the D2 dopamine receptor (DRD2) and alcohol dehydrogenase 2 (ADH2) genes were determined in 69 French Polynesian alcoholic patients 57 controls matched for racial origin. Three groups studied: pure Polynesians (PP), mixed with Caucasian (PCA) ancestry Chinese (PCH) ancestry. DRD2 A1 allele frequencies alcoholics compared to their these were: PP,.26 vs .32 ( P = .69); PCA, .44 .35 .46); PCH, .40 0.39 .88). ADH2 1 PP, .56 .62 .66); .75 .09); .78 .009). In PCA group,...
Scotland has the highest rate of drug related deaths (DRD) in Europe. These are people who use drugs such as heroin, cocaine, benzodiazepines and gabapentinoids. It is a feature that combinations which increases chance DRD. Many involve 'street' benzodiazepines, especially called etizolam. not licensed UK so come from illegal sources. People opiates can be prescribed safer replacement medication (e.g., methadone). While guidance on management highlights there little evidence to support...
Summary Twelve weeks sofosbuvir/velpatasvir (SOF/VEL) is a highly effective pan‐genotypic regimen for hepatitis C. Phase 2 data suggest 8 of treatment may be sufficient previously untreated noncirrhotic patients with genotype 3 (GT3) infection. To maximize the number potentially cured within fixed budget, we elected to treat such locally eligible (F2/3), SOF/VEL. By local protocol, treatment‐naive F2 (LSM > 6.9kPa < 9.5kPa) or F3 fibrosis (≥9.5kPa 12.5kPa) were 8‐week SOF/VEL...
The apolipoprotein E4 (APOE*4) allele is a major risk factor for the common forms of late-onset Alzheimer disease (AD), but does not account all genetic variation in AD; hence, other markers must be examined. D2 dopamine receptor (DRD2) A1 associated with abnormal brain function and decreased DRD2s. These receptors are hippocampus amygdala AD, frequencies may vary age.To study APOE DRD2 genotypes patients AD cognitively intact controls varying ages.The were examined 832 unrelated white...
Abstract Background In the context of an outbreak HIV among people who inject drugs in Glasgow, Scotland, identified 2015, our objectives were to: (1) develop epidemiological methods to estimate incidence using data linkage, and (2) examine temporal changes inform public health responses. Methods This was a retrospective cohort study involving linkage laboratory testing identify individuals with history drug use. Person‐years (PY) Poisson regression used by time period (pre‐outbreak:...
Resumen Se determinaron los alelos de genes del receptor D2 dopamina (DRD2) y alcohol deshidrogenasa 2 (ADH2) en 69 pacientes alcohólicos la Polinesia francesa 57 controles empa- rejados cuanto a su origen racial. estudiaron tres grupos raciales: polinesios puros (PP), mezclados con ascendencia caucasiana (PACauc) china (PACh). En estos grupos, las frecuencias alelo Al DRD2 comparación sus fueron: PP: 0,26 frente 0,32 (P = 0,69); PACauc: 0,44 0,35 0,46); PACh: 0,40 0,39 0,88). Las 1 ADH2...