A5005260007- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Biochemical Analysis and Sensing Techniques
- Eating Disorders and Behaviors
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Sleep and related disorders
- Pharmacological Receptor Mechanisms and Effects
- Pancreatic function and diabetes
- Remote Sensing and Land Use
- Tryptophan and brain disorders
- Gut microbiota and health
- Nicotinic Acetylcholine Receptors Study
- Dietary Effects on Health
- Advanced Photocatalysis Techniques
- Obsessive-Compulsive Spectrum Disorders
- Circadian rhythm and melatonin
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pain Mechanisms and Treatments
- Treatment of Major Depression
Università di Camerino
2020-2024
University of Perugia
2017
Abstract Objective Binge‐eating disorder is an eating characterized by recurrent binge‐eating episodes, during which individuals consume excessive amounts of highly palatable food (HPF) in a short time. This study investigates the intricate relationship between repeated episode and transcriptional regulation two key genes, adenosine A 2A receptor ( AR ) dopamine D2 D2R ), selected brain regions rats. Method Binge‐like behavior on HPF was induced through combination restrictions frustration...
Consumption of energy-dense palatable "comfort" food can alleviate stress and negative emotions, while abrupt withdrawal from a diet worsen these symptoms, causing difficulties with adherence to weight-loss diets. Currently, no pharmacological treatment is effective for obesity-related anxiety, so we investigated the endocannabinoid system (ECS), specifically fatty acid amide hydrolase (FAAH), as an interesting emerging target in this context because its key role regulation both energy...
Recurrent Binge Eating (BE) episodes characterize several eating disorders. Here, we attempted to reassemble a condition closer BE disorder, and analyzed whether recurrent might evoke molecular alterations in the hypothalamus of rats. The is brain region which sensitive stress relevant motivated behaviors, such as food intake. A well-characterized animal model BE, history intermittent restriction induce binge-like palatable consumption, was used analyze transcriptional regulation...
Abstract Objective Test the efficacy of selective orexin 1 receptor (OX1R) antagonist (SO1RA) nivasorexant in an animal model binge‐eating disorder (BED) and study its dose–response relationship considering free brain concentrations calculated OX1R occupancy. Compare nivasorexant's profile to that other, structurally diverse SO1RAs. Gain understanding potential changes orexin‐A (OXA) neuropeptide deltaFosB (ΔFosB) protein expression possibly underlying development phenotype rat used. Method...
Changes in functionality and composition of gut microbiota (GM) have been associated may contribute to the development maintenance obesity related diseases. The aim our study was investigate for first time impact Lactiplantibacillus (L.) plantarum IMC 510 a rat model diet-induced obesity, specifically cafeteria (CAF) diet. This diet provides strong motivation voluntary overeat, due palatability variety selected energy-dense foods. oral administration 84 days this probiotic strain, added CAF...
In this paper, the benzo-cracking approach was applied to potent sigma1 (σ1) receptor antagonist 1 afford less conformationally constrained 1,3-dioxane derivatives 2 and 3. To evaluate effect of increase in distance between two hydrophobic structural elements that flank basic function, cis trans diastereomers 4 5 were also prepared studied. Compounds 3 showed affinity values at σ1 significantly higher than lead compound 1. particular, displayed unprecedented selectivity over σ2 receptor,...
Background: Alterations of dopamine (DA) transmission in the brain reward system can be associated with an addictive-like state defined as food addiction (FA), common obese individuals. Subjects affected by FA experience negative feelings when abstinent from their preferred diet and may develop mood disorders, including depression, sustained alterations DA pathways. Objective: This study aims to investigate impact long-term abstinence a palatable on depressive-like behavior rats, exploring...
There is a strong relationship between palatable diet and pain sensitivity, the cannabinoid opioid systems might play an important role in this correlation. The used many animal models of obesity cafeteria (CAF), based on human food with high sugar, salt, fat content. In study, we investigated whether long-term exposure to CAF could modify sensitivity explored cannabinergic system modification. Male Sprague-Dawley rats were divided into 2 groups: one fed standard chow only (CO) other...
Maladaptive eating behavior is a growing public health problem and compulsively excessive food in short time, or binge eating, key symptom of many disorders. In order to investigate the binge-like female rats, induced by intermittent restrictions/refeeding frustration stress, we analyzed for first time metabolic profile obtained from serum through nuclear magnetic resonance (NMR) spectroscopy. this experimental protocol, rats were exposed chow restricting/refeeding stress manipulation. This...
During the last years, application of Structural Health Monitoring (SHM) systems to heritage constructions has received a great interest due low invasiveness and low-cost necessary equipment.When applied monumental structures and, more in general, cultural ones, such SHM represent an effective solution for preventive conservation against both material degradation damages derived by natural hazards, as earthquakes.Among various technical solutions currently available SHM, vibration-based...