A5054067473- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Endometrial and Cervical Cancer Treatments
- Bioinformatics and Genomic Networks
- Prostate Cancer Diagnosis and Treatment
- Gene expression and cancer classification
- Gynecological conditions and treatments
- Genetic and phenotypic traits in livestock
- Sperm and Testicular Function
- Reproductive tract infections research
- Bee Products Chemical Analysis
- Social and Political Issues
- Health, Nursing, Elderly Care
- Sexual function and dysfunction studies
- Environmental and Ecological Studies
- Reproductive Physiology in Livestock
- Social and Economic Solidarity
- Urologic and reproductive health conditions
- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- Spaceflight effects on biology
- Ureteral procedures and complications
- Medicinal Plant Pharmacodynamics Research
Instituto de Investigación Biosanitaria de Granada
2022-2025
Universidad de Jaén
2018-2024
Universidad de Granada
2022-2024
Brazilian Agricultural Research Corporation
2010
In recent years, high-throughput sequencing technologies have revolutionised reproductive microbiome research. Our understanding of the endometrial is primarily based on DNA-based 16S rRNA gene profiling, but DNA detection does not imply alive microbe presence. While this method cost-effective and widely used, it has notable limitations, including underestimation microbial diversity, abundance, functionality, as well limited species-level resolution. Meta-transcriptomic analysis, an...
Abstract STUDY QUESTION Do women with endometriosis have a different endometrial gene expression profile at the time of embryo implantation than without endometriosis? SUMMARY ANSWER The differs from that mid-secretory phase, although differences are small. WHAT IS KNOWN ALREADY About 50% suffer infertility. Several molecular studies suggested impaired receptivity in endometriosis, while others detected no dysregulation receptivity. Nevertheless, previous transcriptome comparing and been...
Uterine pathologies pose a challenge to women’s health on global scale. Despite extensive research, the causes and origin of some these common disorders are not well defined yet. This study presents comprehensive analysis transcriptome data from diverse datasets encompassing relevant uterine such as endometriosis, endometrial cancer leiomyomas. Leveraging Comparative Analysis Shapley values (CASh) technique, we demonstrate its efficacy in improving outcomes classical differential expression...
Uterine pathologies pose a challenge to women’s health on global scale. Despite extensive research, the causes and origin of some these common disorders are not well defined yet. This study presents comprehensive analysis transcriptome data from diverse datasets encompassing relevant uterine such as endometriosis, endometrial cancer leiomyomas. Leveraging Comparative Analysis Shapley values (CASh) technique, we demonstrate its efficacy in improving outcomes classical differential expression...
Which genes regulate receptivity in the epithelial and stromal cellular compartments of human endometrium, which molecules are interacting implantation process between blastocyst endometrial cells?A set receptivity-specific cells was identified, role galectins (LGALS1 LGALS3), integrin β1 (ITGB1), basigin (BSG) osteopontin (SPP1) embryo-endometrium dialogue among many other protein-protein interactions were highlighted.The molecular taking place embryo endometrium is poorly understood due to...
Abstract Study question Does the analysis of endometrial microbiome provide same information when using DNA or RNA sequencing-based techniques? Summary answer vs. RNA-based techniques demonstrate significant microbial compositional differences, meaning that previous 16S rRNA gene-based results might be overestimated. What is known already In recent years, high-throughput sequencing technologies have revolutionised field reproductive research. Our understanding composition predominantly...
Abstract Study question Does seminal microbiome differ between men with good and poor sperm quality parameters? Summary answer Men values presented a higher microbial richness, while after rigorous contamination controlling no specific bacteria associated parameters. What is known already Infertility represents major health concern affecting 1 in every 6 couples. Approximately 50% of infertility cases are attributed to male factor, where crucial. Recent studies have brought light the role...
Abstract Study question Does semen harbour functionally active microorganisms, and whether the microbial composition associate with quality parameters? Summary answer Seminal fluid harbours alive microorganisms including bacteria, viruses, archaea, viroids fungi whose metabolic functions parameters. What is known already has been shown to possess different microbes, where bacteria have associated spermatogenesis, seminal parameters infertility. Nevertheless, previous results are inconclusive...
Abstract Study question Does the endometrium possess alive, culturable bacteria, and are there any microbes associated with endometriosis? Summary answer Thirty-five cultured bacterial species were identified in receptive-phase endometrium, an endometriosis-specific profile was detected. What is known already Endometriosis a chronic inflammatory disease one of most prevalent female reproductive disorders, but its etiology remains unknown. Recently, significant attention has been directed...
La labor de identificación fenómenos climáticos mediante la utilización mediciones radar se ve notablemente dificultada por presencia interferencias provenientes del entorno terrestre. objetos u obstáculos que causan desviaciones en el haz resulta generación ecos alta intensidad comprometen integridad las y vician al proceso detección. En contexto este estudio, propone consecución un modelo concebido con finalidad discernir catalogar células contaminadas tierra, procediendo posteriormente a...
Neurological disorders such as Autism Spectrum Disorder (ASD), Schizophrenia (SCH), Bipolar (BD), and Major Depressive (MDD) affect millions of people worldwide, yet their molecular mechanisms remain poorly understood. This study applied the Comparative Analysis Shapley values (CASh) to transcriptomic data from nine datasets associated with these complex disorders, demonstrating its effectiveness in identifying differentially expressed genes (DEGs). CASh, which integrates Game Theory...
Abstract Study question Do gut microbial composition and functionality differ between women with without endometriosis? Summary answer Gut microbiome diversity (species pathways) were not significantly different endometriosis. What is known already Endometriosis, defined as the presence of endometrial-like tissue outside uterus, one most common female reproductive disorders. Although theories possible causes endometriosis have been proposed, its pathogenesis clear. Novel studies indicate...
Abstract Study question Does male sterilisation with vasectomy induce changes in the seminal microbiome composition? Summary answer Human semen harbours an enriched microbial community and composition significantly differed samples from same men before after vasectomy. What is known already The a polymicrobial community, where Lactobacillus, Corynebacterium, Staphylococcus, Prevotella, Finegoldia are common. origin of microbiome, however, has not yet been established. One-third microbes...
Abstract Study question Are there differential transcriptomic profiles of the receptive phase endometria in infertile women with different infertility diagnoses? Summary answer Endometrium-related pathologies such as endometriosis and RIF seemed to share similar endometrial molecular mid-secretory phase,while samples from unexplained were controls. What is known already Successful embryo implantation orchestrated by combination a viable blastocyst, endometrium perfectly synchronized dialogue...
Nutritional status is essential for the determination of mammalian reproductive performance, and insulin one main indicators such condition. This hormone able to interfere, directly or indirectly, with CL function, leading alterations in steroidogenic capacity cell development and, consequently, early embryonic development. The aim this work was identify histological caused by different plasma concentrations superovulated ewes, as well their interference progesterone production. Santa Inês...
Abstract Study question What is the entire metabolomic profile of receptive-phase human endometrium and does metabolic composition differ between women with different infertility diagnosis? Summary answer Human contains 925 metabolites from diverse chemical classes, signature varies diagnosis. known already Different have been identified in endometrium, including amino acids, nucleosides/nucleotides, organic lipids, sugars, main focus on lipid profiles endometriosis. Metabolic dysregulation...