A5047583948- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Fungal and yeast genetics research
- Escherichia coli research studies
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
- Plant nutrient uptake and metabolism
- Biofuel production and bioconversion
- Cellular transport and secretion
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Heart Rate Variability and Autonomic Control
Université Laval
2021-2024
Institut Cochin
2019-2021
Inserm
2019-2021
Montreal Heart Institute
2021
Université Paris Cité
2019-2020
Centre National de la Recherche Scientifique
2019-2020
Délégation Paris 5
2019
Sorbonne Paris Cité
2019
University of Havana
1991-1999
Centro Nacional de Investigaciones Científicas
1998
ABSTRACT Vibrio cholerae 638 (El Tor, Ogawa), a new CTXΦ-negative hemagglutinin/protease-defective strain that is cholera vaccine candidate, was examined for safety and immunogenicity in healthy adult volunteers. In double-blind placebo-controlled study, no significant adverse reactions were observed volunteers ingesting 638. Four of 42 who ingested 1 14 received placebo experienced loose stools. The strongly colonized the human small bowel, as evidenced by its isolation from stools 37 V....
<b><i>Introduction:</i></b> Metabolic dysfunction is now recognized as a pivotal component of Alzheimer’s disease (AD), the most common dementia worldwide. However, precise molecular mechanisms linking metabolic to AD remain elusive. <b><i>Objective:</i></b> Here, we investigated direct impact soluble oligomeric amyloid beta (Aβ) peptides, main hallmark AD, on leptin system, major central energy metabolism regulation....
Leptin links body energy stores to high demanding processes like reproduction and immunity. Based on leptin's role in autoimmune diseases cancer, several leptin receptor (LR) antagonists have been developed, but these intrinsically lead unwanted weight gain. Here, we report the uncoupling of metabolic immune functions based cross talk with epidermal growth factor (EGFR). We show that both receptors spontaneously interact and, remarkably, this complex can partially overrule lack LR activation...
The liver plays a major role in glucose and lipid homeostasis acts as key organ the pathophysiology of metabolic diseases. Intriguingly, increased sympathetic nervous system (SNS) activity to has been associated with development progression type 2 diabetes obesity. However, precise mechanisms by which SNS regulates hepatic metabolism remain be defined. While alpha1-adrenoceptors were suggested play homeostasis, specific subtypes involved are unknown mainly because limitations pharmacological...
The RS1 element associated with Vibrio cholerae CTXΦ prophage was cloned from an El Tor biotype strain. We used the recA− vaccine strain Peru-15, that lacks target for RS-mediated site-specific integration, to show promotes autonomous replication of a suicide vector. A linker insertion in rstR open reading frame abolished Peru-15 but not containing chromosome. An AT-rich region cis-acting elements involved identified by deletion. This sufficient support DNA sequence analysis present and RS2...
Leptin is an anti-obesity hormone, which circulates in the blood and acts on neuronal cells brain. activates leptin receptor Ob-Rb induces JAK2-STAT3 pathway, thus inducing action. It has been suggested that most forms of obesity are accompanied by resistance to leptin, is, insensitivity action hormone. Obesity also a low-grade inflammation, associated with resistance. In present study, we investigated effect adenosine, produced during signaling. We found adenosine can be transported into...