A5111428881- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Leptospirosis research and findings
- Viral Infections and Vectors
- Escherichia coli research studies
- Vibrio bacteria research studies
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Infective Endocarditis Diagnosis and Management
- Amoebic Infections and Treatments
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Resistance in Bacteria
- Neonatal and Maternal Infections
- Pediatric health and respiratory diseases
- Vaccine Coverage and Hesitancy
- Aquaculture disease management and microbiota
- Allergic Rhinitis and Sensitization
- Essential Oils and Antimicrobial Activity
- Antimicrobial Peptides and Activities
- Tuberculosis Research and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Respiratory viral infections research
- Influenza Virus Research Studies
- vaccines and immunoinformatics approaches
Changchun Institute of Biological Products
2021
Finlay Institute
2005-2017
Presidency University
2007
Universidad de León
1996
Universidade de Santiago de Compostela
1972
ContextMeningococcal disease occurs worldwide, and serogroup B accounts for a large proportion of cases. Although persons younger than 4 years are at greatest risk meningococcal disease, vaccine efficacy has not been demonstrated in this age group.ObjectiveTo evaluate serum bactericidal activity (SBA) against homologous type strains heterologous Chilean epidemic strain Neisseria meningitidis as potential correlate efficacy.DesignDouble-blind, randomized controlled trial conducted between...
Serum bactericidal activity (SBA) and ELISA antibody levels elicited by two efficacious serogroup B meningococcal vaccines were measured in a controlled trial involving 408 15- to 20-year-olds. Subjects given doses at 6-week interval of or control vaccine. Response was defined as > = 4-fold rise level. After the Finlay Institute (Havana) vaccine 12 months, proportions SBA responders not different from those group (15% 17% [vaccine] vs. 13% 9% [control], P .05). National Public Health (Oslo)...
ABSTRACT Vibrio cholerae 638 (El Tor, Ogawa), a new CTXΦ-negative hemagglutinin/protease-defective strain that is cholera vaccine candidate, was examined for safety and immunogenicity in healthy adult volunteers. In double-blind placebo-controlled study, no significant adverse reactions were observed volunteers ingesting 638. Four of 42 who ingested 1 14 received placebo experienced loose stools. The strongly colonized the human small bowel, as evidenced by its isolation from stools 37 V....
The in vitro antistaphylococcal activity of lactoferrin and the antibiotic resistance clinical Staphylococcus aureus isolates obtained from three different sites infection were examined. Antibiotic, but not correlated with selective pressure, nosocomial most community resistant, whereas only a third each group was resistant to lactoferrin. antimicrobial lactoferrin, both defined medium normal human plasma serum, dependent upon its ferrochelating properties. Therapeutic approaches based on...
To evaluate the efficacy of vax-SPIRAL, a Cuban vaccine against leptospirosis, and to provide additional information concerning safety this (which was developed by Cuba's Finlay Institute).This phase III trial vax-SPIRAL controlled, randomized, double blind. The control used for Heberbiovac-HB (Heber Biotec, Cuba), recombinant hepatitis B vaccine. randomization unit allocating persons study group or were 523 family physician offices in selected municipalities. covered entire population males...
Abstract Neisseria meningitidis B proteoliposome (AFPL1 when used as adjuvant) and its derivative‐Cochleate (AFCo1) contain immunopotentiating immunomodulating properties delivery system capacities required for a good adjuvant. Additionally, they meningococcal protective antigens permit packaging of other pathogen‐associated molecular patterns (PAMP). Consequently, we hypothesized that would function vaccine adjuvants their own also non‐related antigens. AFPL1 is detergent‐extracted outer...
ABSTRACT This report explores the participation of some afferent mechanisms in immune response induced by Cuban anti-meningococcal vaccine VA-MENGOC-BC. The induction delayed-type hypersensitivity nursing babies and lymphocyte proliferation after immunization is demonstrated. presence gamma interferon IFN-γ interleukin-2 (IL-2) mRNAs but absence IL-4, IL-5, IL-10 were observed peripheral blood mononuclear cells from immunized subjects vitro challenge with outer membrane vesicles. In...
Background. The serogroup B meningococcus is responsible for the majority of cases meningococcal disease in temperate countries. Infants and young children <2 years age are at greatest risk disease. This study assessed immunogenicity infants a outer membrane protein vaccine that has been used extensively outbreaks Cuba several Latin American countries shown to be efficacious teenagers. Method. One hundred five healthy entering routine vaccination schedule Havana, Cuba, were given either 2 or...
Abstract Proteoliposomes purified from the Outer Membrane of Neisseria meningitidis B, have been successfully used as core for adjuvants and vaccine formulations. We tried to increase their structural definition conserve efficacy stability avoiding addition aluminum hydroxide final formulation. Liposomal particle systems were prepared components defined molecular structure, such a B protein complex, extracted without forming vesicle structures. Liposomes mixture dioleoyl phosphatidyl serine...
EhCPADH is an immunogenic, heterodimeric protein that formed by EhCP112 (cysteine protease) and EhADH112 (adhesin), polypeptides involved in Entamoeba histolytica 's cytopathic effect, target-cell adherence phagocytosis. The complex located the plasma membrane cytoplasmic vacuoles. Here, independent expression of fibroblasts hamsters was analysed. Also investigated immunological response animals independently inoculated with plasmid pcDNA- Ehcp112 , which carries complete cysteine...