A5089972949- Pneumonia and Respiratory Infections
- Blood transfusion and management
- Blood groups and transfusion
- Bacterial Infections and Vaccines
- Hemoglobinopathies and Related Disorders
- Blood donation and transfusion practices
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Platelet Disorders and Treatments
- Respiratory Support and Mechanisms
- Streptococcal Infections and Treatments
- Airway Management and Intubation Techniques
- Metallic Glasses and Amorphous Alloys
- Blood properties and coagulation
- Long-Term Effects of COVID-19
- Neonatal and Maternal Infections
- Peripheral Neuropathies and Disorders
- Infectious Encephalopathies and Encephalitis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vitamin K Research Studies
- Blood disorders and treatments
- Vitamin C and Antioxidants Research
- Diet, Metabolism, and Disease
- Antibiotic Resistance in Bacteria
- Virology and Viral Diseases
Canadian Blood Services
2021
National Medical and Surgical Center named after N.I. Pirogov
2021
Cambridge University Hospitals NHS Foundation Trust
2008-2018
University of Cambridge
2009-2016
NHS Blood and Transplant
2009-2016
Addenbrooke's Hospital
1996-2016
Bridge University
2016
National Health Service
2013
Institute of Child Health
2003
John Radcliffe Hospital
2003
The guideline is a revision of the 2004 British Committee for Standards in Haematology (BCSH) on transfusion neonates and older children (BCSH, 2004). Although there has been little evidence which to base paediatric clinical decisions past, have number studies national audits published over recent years that contribute decision-making this area. In addition changes other guidance, including management neonatal jaundice National Institute Health Clinical Excellence (NICE, 2010) requirement...
Abstract Hematopoiesis is a carefully controlled process that regulated by complex networks of transcription factors are, in part, signals resulting from ligand binding to cell-surface receptors. To further understand hematopoiesis, we have compared gene expression profiles human erythroblasts, megakaryocytes, B cells, cytotoxic and helper T natural killer granulocytes, monocytes using whole genome microarrays. A bioinformatics analysis these data was performed focusing on factors,...
Background. The serogroup B meningococcus is responsible for the majority of cases meningococcal disease in temperate countries. Infants and young children <2 years age are at greatest risk disease. This study assessed immunogenicity infants a outer membrane protein vaccine that has been used extensively outbreaks Cuba several Latin American countries shown to be efficacious teenagers. Method. One hundred five healthy entering routine vaccination schedule Havana, Cuba, were given either 2 or...
Abstract Background and Objectives Platelets for transfusion have a shelf‐life of 7 days, limiting availability leading to wastage. Cryopreservation at −80°C extends least 1 year, but safety effectiveness are uncertain. Materials Methods This single centre blinded pilot trial enrolled adult cardiac surgery patients who were high risk platelet transfusion. If treating clinicians determined was required, up three units either cryopreserved or liquid‐stored platelets intraoperatively during...
Acquired coagulopathy is a relatively uncommon occurrence in acute paediatrics but when it occurs usually associated with significant underlying pathology and often critical illness. It can be caused by number of disease processes infection, blood loss, iatrogenic causes liver dysfunction are among the commonest. The coagulation cascade complex intersects many other physiological pathways. also subject to developmental changes, 'normal' haemostasis change considerably during early life....
SUMMARY Objective To describe the epidemiology of blood transfusion in children: including incidence transfusion, diagnoses leading to donor exposure ( DE ) and post‐transfusion survival. Study design methods The Epidemiology Survival Transfusion Recipients (EASTR) was a multi‐centre epidemiological study with prospective survival monitoring. Cross‐sectional sampling adult paediatric recipients 29 hospitals used select three separate cohorts red cell RBC ), platelet PLT fresh frozen plasma...
Current procedures for thawing and issuing of cryopreserved platelets (CPPs) are laborious have remained challenging in emergency settings such as blood banks military operations. In this prospective study, a novel processing method designed to facilitate the rapid issuance CPPs with no postthaw handling required was developed functionally characterized parallel standard manufactured.
Background and Objectives Efficiency in mitigating HIV transmission risk by transfusion may vary internationally. We compared prevalence incidence blood donors across different jurisdictions relation to those rates the general population differences deferral practices. Materials Methods Data from 2007 2016 were collected Australia, Brazil (São Paulo), Canada, England, France, Italy, Ireland, Japan, Netherlands, New Zealand, Norway, Spain (Basque Country), USA (Vitalant) Wales. For each...
SUMMARY Objective To determine the long‐term survival of adult recipients (>16 years) transfused with red blood cells ( RBC ), platelets PLT ) and fresh frozen plasma FFP in England Wales. Study design methods The EASTR study (Epidemiology Survival Transfusion Recipients) was a national multi‐centre epidemiological cross‐sectional sampling from 29 representative hospitals supplied by NHS Blood Transplant NHSBT ). Three separate groups n = 9142), 4232) (3584) were sampled over 1 year (1...
To determine the association between ability of a different strains meningococci to survive in whole blood and age donor.A panel serogroup B C strain Neisseria meningitidis was tested an ex vivo model. Blood from 81 healthy children 20 adults during convalescence (55 patients) or (43 meningococcal infection assessed.Age-dependent acquisition killing bacterial isolates demonstrated with inverse relationship reported incidence disease. After meningococci, evidence bacteria found even <2 years...
We present an unusually severe case of pneumococcal infection in immunocompetent child who progressed from pneumonia to empyema, pericarditis with cardiac tamponade, and venous thromboembolism leading life-threatening pulmonary embolus.
Background Studies show that 1 in 1200 neonates have a low platelet ( PLT ) count due to alloimmunization against human antigen HPA )‐1a (β 3 ‐ L 33). This mainly occurs ‐1a–negative mothers who are positive for the leukocyte HLA )‐ DRB 3*01:01 allele, but only about one‐third of cases will mount an effective alloimmune response. The development specific treatment modalities requires mechanisms driving maternal response fetal PLTs be further explored. An antibody reagent has different...
Background and aims: Two children with ventilator dependence secondary to spinal injury underwent insertion of bilateral Atrostim Implantable Phrenic Nerve Stimulators (IPNS). We studied both children, before after IPNS, using Structured Light Plethysmography (SLP) (Thora3Di TM PneumaCare Ltd, UK), a novel non-invasive method which captures functional images the lungs by analysing chest wall movement, translates this data into pulmonary function outputs. Aims: aimed determine whether SLP...
<h3>Aim</h3> NHS England has outlined the Neonatal Intensive Care Unit (NICU) service to be for infants who are generally (but not exclusively)<44 weeks corrected gestational age (CGA). There implications Paediatric (PICU) and general paediatric wards in terms of managing this workload, transitioning complex infants. Following challenges accommodating some these cases within our services, we conducted a study assess workload outcomes transferred from NICU after 44 CGA over 5 year period....
Background and aims: Septic shock remains a leading cause of morbidity mortality. Whilst mortality has reduced with improvements in critical care management, there is evidence from adult septic patients that early diagnosis aggressive treatment (‘goal directed therapy’) improves outcome. Best practice guidelines for paediatric include intervention fluid resuscitation, ventilator circulatory support correction metabolic disturbances3. Aims: We set out to determine the level compliance current...