A5091089371- Chemotherapy-induced organ toxicity mitigation
- Acute Kidney Injury Research
- Blood disorders and treatments
- Acute Lymphoblastic Leukemia research
- Platelet Disorders and Treatments
- RNA Interference and Gene Delivery
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- MicroRNA in disease regulation
- Immunodeficiency and Autoimmune Disorders
- Childhood Cancer Survivors' Quality of Life
- Neutropenia and Cancer Infections
- Thyroid and Parathyroid Surgery
- Mesenchymal stem cell research
- Magnesium in Health and Disease
- Birth, Development, and Health
- Renal function and acid-base balance
- Liver Diseases and Immunity
- Electrolyte and hormonal disorders
- Renal and related cancers
- Complement system in diseases
- Blood groups and transfusion
- Neonatal Health and Biochemistry
- Dialysis and Renal Disease Management
- ATP Synthase and ATPases Research
Schneider Children's Medical Center
2013-2024
Hospital for Sick Children
2020-2024
Emek Medical Center
2021-2024
University of Toronto
2020-2024
SickKids Foundation
2020-2024
Technion – Israel Institute of Technology
2021
Tel Aviv University
2014-2020
Moncton Hospital
2018
Hôpitaux Universitaires Henri-Mondor
2018
Assistance Publique – Hôpitaux de Paris
2018
Our aim was to identify miRNAs that can predict risk of relapse in pediatric patients with acute lymphoblastic leukemia (ALL). Following high‐throughput miRNA expression analysis (48 samples), five miRs were selected for further confirmation performed by real time quantitative PCR on a cohort precursor B‐cell ALL ( n = 138). The results correlated clinical parameters and outcome. Low miR‐151‐5p, miR‐451, high miR‐1290 or combination all three predicted inferior free survival P 0.007, 0.042,...
Background The relative frequency of mutated genes among patients with severe congenital neutropenia (SCN) may differ between various ethnic groups. To date, few population‐based genetic studies have been reported. This study describes the analysis 32 Israeli SCN. Procedures Clinical data were retrieved from prospective Inherited Bone Marrow Failure Registry. Recruitment included living and deceased who diagnosed 1982 2012, for whom molecular diagnosis was performed. ELANE , HAX1 G6PC3...
Apparent mineralocorticoid excess (AME) syndrome is an ultra-rare autosomal-recessive tubulopathy, caused by mutations in HSD11B2, leading to excessive activation of the kidney receptor, and characterized early-onset low-renin hypertension, hypokalemia, risk chronic disease (CKD). To date, most reports included few patients, none described patients from Israel. We aimed describe AME Israel review relevant literature.
Infections is a common complication of nephrotic syndrome (NS). Our objective was to evaluate the frequency and risk factors for serious bacterial infections (SBI) in febrile children with NS. We reviewed 239 admissions 107 NS who were admitted fever tertiary hospital Israel, during 1995 2016. SBI diagnosed 35 (14.6%), most commonly pneumonia (n = 12), bacteremia/sepsis 8), urinary tract infection 6). Patients more likely be female (60.0% vs 36.3%, P .008) have nephrotic-range proteinuria...
Abstract Background Congenital neutropenias are characterized by severe infections and a high risk of myeloid transformation; the causative genes vary across ethnicities. The Israeli population is an ethnically diverse with rate consanguinity. Objective To evaluate clinical genetic spectrum congenital in Israel. Methods We included individuals listed Inherited Bone Marrow Failure Registry. Sanger sequencing was performed for ELANE or G6PC3 , patients wild‐type ELANE/G6PC3 were referred...
Background: The potential of hypophosphatemia (HP) to differentiate between febrile syndromes and its clinical significance in children without sepsis were not previously described. Methods: Data retrospectively collected 3 months 18 years age, hospitalized at general pediatric wards during 2010–2019. Phosphate levels compared bacterial infection (BI), viral (VI), Kawasaki disease (KD). Regression analyses used evaluate the relationship HP outcome. Results: Of 3963 children, 559 had BI, 3271...
Adenovirus is a common pediatric pathogen responsible for wide variety of infections. Despite this, secondary bacteremia following an adenovirus infection has not been previously systematically described. Herein, we describe seven cases in hospitalized children during 8-year period. Pediatricians should be informed this serious complication.
Abstract Context Bartter syndrome (BS) is a group of rare autosomal-recessive tubulopathies characterized by hypokalemic, hypochloremic metabolic alkalosis in which the primary defect deficiency transporters involved sodium chloride reabsorption. Type 2 BS results from renal outer medullary potassium channel encoded KCNJ1 gene. presents with polyhydramnios, intrauterine growth retardation, prematurity, failure to thrive, polyuria, hypercalciuria, and life-threatening episodes dehydration....
Approximately 30% of childhood cancer survivors (CCSs) will develop chronic kidney disease (CKD) or hypertension 15 to 20 years after treatment ends. The incidence CKD and in the 5-year window therapy is unknown. Moreover, extent monitoring CCS with associated complications current practice underexplored. To inform development new existing care guidelines for CCS, epidemiology early period following warrants further investigation.To describe design methods KIdney aNd blooD prESsure ouTcomes...
Cisplatin is a chemotherapeutic agent highly excreted in urine and known to cause acute kidney injury (AKI). As AKI diagnosis by serum creatinine (SCr) usually delayed, endeavors for finding early biomarkers continue. This study aims determine if platinum (UP) concentration 24 hours after cisplatin infusion associated with AKI, evaluate the association between tubular damage biomarkers: neutrophil gelatinase-associated lipocalin (NGAL) molecule-1 (KIM-1). Children treated 12 Canadian centers...
e22003 Background: Urine kidney injury biomarkers measured during cisplatin therapy may help identify patients at risk for adverse long-term outcomes. In children treated cancer, we examined associations of urine tubular collected two cycles, with chronic disease (CKD) and hypertension 3 12 months post-cisplatin. Methods: We analyzed data from the Applying Biomarkers to Minimize Long-Term Effects Childhood/Adolescent Cancer Treatment (ABLE) Nephrotoxicity Study: a twelve-center prospective...
Background: Malignant gliomas are the most common and deadly brain tumors. Mean survival rate for a patient diagnosed with glioblastoma multiforme (GBM) remains slightly over one year. Standard of care consists treatment temozolomide (TMZ) radiotherapy. Recent work has highlighted functions long non-coding RNAs (lncRNAs) in GBM progression TMZ response even though information regarding these newly discovered molecules is sparse. The overarching objective this project was thus to assess...