A5073875236- Cancer, Stress, Anesthesia, and Immune Response
- Immune Cell Function and Interaction
- Inflammatory mediators and NSAID effects
- Neuropeptides and Animal Physiology
- Chemokine receptors and signaling
- Immune cells in cancer
- Immune Response and Inflammation
- Stress Responses and Cortisol
- Anesthesia and Pain Management
- Cancer, Hypoxia, and Metabolism
- Enhanced Recovery After Surgery
- Immunotherapy and Immune Responses
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- Hereditary Neurological Disorders
- Cancer Treatment and Pharmacology
- Oral health in cancer treatment
- Antimicrobial Peptides and Activities
- Vitamin C and Antioxidants Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Dementia and Cognitive Impairment Research
- Blood Coagulation and Thrombosis Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
Schneider Children's Medical Center
2023
Tel Aviv University
2007-2023
Tel Aviv Sourasky Medical Center
2022
Institute of Neuroimmunology of the Slovak Academy of Sciences
2010
Surgical procedures, including primary tumor resection, have been suggested to suppress immune competence and promote postoperative infections cancer metastasis. Catecholamines prostaglandins were recently implicated in these processes, directly promoting angiogenesis invasion.To examine the integration of 2 complementary approaches reduce immunosuppression metastatic progression: (1) perioperative immunostimulation with CpG-C (2) pharmacological blockade tumor-promoting immunosuppressing...
Clinical practice does not consider perioperative paracrine and neuroendocrine stress responses as risk factors for cancer recurrence, although recent animal studies provided supportive evidence. Suggested mechanisms include the effects of stress-hormones on tumor cells host physiology. In this study, in mice undergoing primary excision, we tested survival-enhancing potential blockade catecholamines prostaglandins, studied mediating mechanisms. C57BL/6J were inoculated intrafootpad with...
In leukemia patients, stress and anxiety were suggested to predict poorer prognosis. Oncological patients experience ample physiological psychological stress, potentially leading increased secretion of factors, including epinephrine, corticosteroids, prostaglandins. Here we tested whether environmental these factors impact survival leukemia-challenged rats, studied mediating mechanisms. F344 rats administered with a miniscule dose 60 CRNK-16 cells, subjected intermittent forced swim or...
Introduction: Heavy menstrual bleeding (HMB) poses a significant concern among adolescents and can arise from disorders. This study aimed to compare the clinical presentations treatment of with HMB, distinguishing those without an underlying disorder. Methods: We conducted retrospective analysis adolescent patients presenting HMB during 2014-2022 at specialized hematology-adolescent clinics in two tertiary referral hospitals Israel. The was approved by Institutional Review Boards. Results:...
Surgery remains an essential therapeutic approach for most solid malignancies, including breast cancer. However, surgery also constitutes a risk factor promotion of pre-existing micrometastases and the initiation new metastases through several mechanisms, release prostaglandins stress hormones (e.g., catecholamines glucocorticoids). perioperative period presents opportunity cell mediated immunity (CMI) other mechanisms to eradicate or control minimal residual disease, provided that...
Suppression of natural killer (NK) cell activity is common after stress, has been reported to predict malignant recurrence in cancer patients, and was shown underlie metastatic dissemination animal models. We have previously that catecholamines play a major role NK suppression, particularly the context physiologic stress surgery. In current study using Fisher 344 rats, we examined prophylactic use different regimens type-C CpG oligodeoxynucleotides (CpG-C ODN) on pharmacologic (using...
A significant role has been indicated for cellular immunity in controlling circulating cancer cells, but most autologous tumor cells seem resistant, vitro, to natural killer cell (NKC) and cytotoxic T lymphocytes cytotoxicity. Addressing this apparent contradiction, we recently identified a unique leukocyte population, marginating-pulmonary (MP)-leukocytes, which exhibit potent (NK) Here, characterize the MP-compartment naive immunostimulated rats, assessed its cytotoxicity against...
Invasive Fusarium species infections in immunocompromised patients occur predominantly those with hematological malignancies. Survival rates of 20−40% were reported adults, but data children are limited. Our retrospective, nationwide multicenter study invasive fusariosis pediatric hematology/oncology and stem cell transplant (SCT) identified twenty-two cases. Underlying conditions included malignancies (n = 16; 73%), solid tumors 2), non-malignant 4). Nineteen (86%) neutropenic, nine (41%)...
Abstract Background Congenital neutropenias are characterized by severe infections and a high risk of myeloid transformation; the causative genes vary across ethnicities. The Israeli population is an ethnically diverse with rate consanguinity. Objective To evaluate clinical genetic spectrum congenital in Israel. Methods We included individuals listed Inherited Bone Marrow Failure Registry. Sanger sequencing was performed for ELANE or G6PC3 , patients wild‐type ELANE/G6PC3 were referred...
Objective: COX inhibitors and b-adrenergic blockers were recently shown to reduce cancer progression in animal models through various mechanisms.These include the prevention of immune suppression during critical perioperative period, preclusion direct promoting effects catecholamines prostaglandins on malignant tissue growth.To assess safety such pharmacological treatments context oncologic surgery, current study evaluates wound healing efficacy skin, muscle, colon tissues rats undergoing...
Abstract Background Infantile myofibromatosis (IM) is a rare benign fibrous tumor with diverse clinical presentations and treatments, such as watchful waiting, surgical excision, low‐dose chemotherapy. Procedure Clinical presentation tailored treatment of five infants solitary generalized IM are described, together review the literature. Results Three patients underwent total‐body magnetic resonance imaging (MRI) at diagnosis during follow up, which revealed disease extension that aided in...
Retinal vein occlusion (RVO) and superior ophthalmic thrombosis (SOVT) are rare diseases in the pediatric population; however, neurologic morbidity significant. As published data scarce for these conditions, we present our experience with ocular venous four patients, discuss recommended management evaluation treatment. We suggest performing thrombophilia workup all patients RVO or SOVT. In risk factors additional thrombi, highly recommend initiating anticoagulation therapy. There is a need...
reviewed; 112 (mean age 8.48 years, SD ± 5.3; males 66) had objectively confirmed TE.Eight algorithms were tested using ICD-9 and ICD-10 codes for the whole cohort (Table 1) and, early (< 04/2002) later ( ≥0 4/ 2002, solely codes) periods.Step 1 algorithm with anticoagulation utilization was best performing algorithm.Sensitivity higher period 2).Conclusion(s): An based on combination of any TE has 75% sensitivity 85% specificity diagnosis; only improve to 84% at 80%.This provides a valid...