A5067274774- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Cell Image Analysis Techniques
- Neuroscience and Neural Engineering
- Respiratory Support and Mechanisms
- Retinal Development and Disorders
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- Nanopore and Nanochannel Transport Studies
- Microfluidic and Capillary Electrophoresis Applications
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Advanced biosensing and bioanalysis techniques
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Neuropharmacology Research
- Machine Learning in Healthcare
- Scientific Computing and Data Management
- Advanced Fluorescence Microscopy Techniques
- Memory and Neural Mechanisms
- Analytical Chemistry and Sensors
- Neural Networks and Applications
- Gender Diversity and Inequality
- Health, Environment, Cognitive Aging
- Image Processing Techniques and Applications
Princeton University
2020-2025
University of Delaware
2025
Max Planck Institute for Dynamics and Self-Organization
2014-2021
Max Planck Institute of Experimental Medicine
2015-2021
Neuroscience Institute
2021
Bernstein Center for Computational Neuroscience Göttingen
2014-2017
Focus (Germany)
2014-2015
University of Göttingen
2014-2015
University of Würzburg
2014-2015
Jülich Aachen Research Alliance
2011-2012
Peer review is the cornerstone of scholarly publishing and it essential that peer reviewers are appointed on basis their expertise alone. However, difficult to check for any bias in peer-review process because identity generally remains confidential. Here, using public information about identities 9000 editors 43000 from Frontiers series journals, we show women underrepresented process, both genders operate with substantial same-gender preference (homophily), mechanisms this homophily...
Many laboratories use two-photon microscopy through commercial suppliers, or homemade designs of considerable complexity. The integrated nature these systems complicates customization, troubleshooting, and training on the principles microscopy. Here, we present “Twinkle”: a microscope for Two-photon Imaging in Neuroscience, Kit Learning Education. It is fully open, high performing easy-to-set-up that can effectively be used both education research. instrument features >1 mm field view,...
We present a new nanocavity device for highly localized on-chip recordings of action potentials from individual cells in network. Microelectrode have become the method choice recording extracellular high density cultures or slices. Nevertheless, interfacing network with resolution still remains challenging due to an insufficient coupling signal small electrodes, exhibiting diameters below 10 µm. show that this problem can be overcome by type sensor features electrode, which is accessed via...
Orientation preference maps (OPMs) are a prominent feature of primary visual cortex (V1) organization in many primates and carnivores. In rodents, neurons not organized OPMs but instead interspersed "salt pepper" fashion, although clusters orientation-selective have been reported. Does this fundamental difference reflect the existence lower size limit for orientation columns (OCs) below which they cannot be scaled down with decreasing V1 size? To address question, we examined one smallest...
Mechanical ventilators are safety-critical devices that help patients breathe, commonly found in hospital intensive care units (ICUs)-yet, the high costs and proprietary nature of commercial inhibit their use as an educational research platform. We present a fully open ventilator device-The People's Ventilator: PVP1-with complete hardware software documentation including detailed build instructions DIY cost $1,700 USD. validate PVP1 against both key performance criteria specified U.S. Food...
We present a model to describe the response of chip-based nanocavity sensors during extracellular recording action potentials. These feature microelectrodes which are embedded in liquid-filled cavities. They can be used for highly localized detection electrical signals on chip. calculate sensor's impedance and simulate propagation Subsequently we apply our findings analyze cell-chip coupling properties. The results compared experimental data obtained from cardiomyocyte-like cells. show that...
The architecture of iso-orientation domains in the primary visual cortex placental carnivores and primates apparently follows species invariant quantitative laws. Dynamical optimization models assuming that neurons coordinate their stimulus preferences throughout cortical circuits linking millions cells specifically predict these invariants. This might indicate V1's intrinsic connectome its functional adhere to a single principle with high precision robustness. To validate this hypothesis,...
It has been argued that the emergence of roughly periodic orientation preference maps (OPMs) in primary visual cortex (V1) carnivores and primates can be explained by a so-called statistical connectivity model. This model assumes input to V1 neurons is dominated feed-forward projections originating from small set retinal ganglion cells (RGCs). The typical spacing between adjacent cortical columns preferring same then arises via Moiré-Interference hexagonal ON/OFF RGC mosaics. While this...
The rise of large scientific collaborations in neuroscience requires systematic, scalable, and reliable data management. How this is best done practice remains an open question. To address this, we conducted a science survey among currently active U19 grants, funded through the NIH’s BRAIN Initiative. was answered by both liaisons Principal Investigators, speaking for ∼500 researchers across 21 nation-wide collaborations. We describe tools, technologies, methods use, identify several...
We present a fully open ventilator platform–The People’s Ventilator: PVP1– with complete documentation and detailed build instructions, DIY cost of $1,300 USD. Here, we validate PVP1 against key performance criteria specified in the U.S. Food Drug Administration’s Emergency Use Authorization for Ventilators. Notably, performs well over wide range test conditions has been demonstrated to perform stably minimum 72,000 breath cycles three days mechanical lung. As an project, can enable both...
Short-term plasticity gates information transfer across neuronal synapses and is thought to be involved in fundamental brain processes, such as cortical gain control sensory adaptation. Neurons employ synaptic vesicle priming proteins of the CAPS Munc13 families shape short-term vitro, but relevance this phenomenon for processing intact unknown. By combining stimulation with vivo patch-clamp recordings anesthetized mice, we show that genetic deletion CAPS-1 thalamic neurons results more...
Key points Responses to natural scenes are the business of retina. We find primate ganglion cell responses such consistent with those simpler stimuli. A biophysical model confirmed this and predicted close retinal reliability. Primate were driven by temporal variations in colour luminance over receptive field centre caused eye movements, little influenced interaction surround structure scene. discuss implications context efficient coding visual environment. Much information a higher...
Decision making is traditionally thought to be mediated by populations of neurons whose firing rates persistently accumulate evidence across time. However, recent decision-making experiments in rodents have observed the brain that fire sequentially as a function spatial position or time, rather than persistently, with subset sequence depending on animal's choice. We develop two new candidate circuit models, which encoded either relative competing chains network location stereotyped pattern...
A bstract We consider the problem of controlling an invasive mechanical ventilator for pressure-controlled ventilation: a controller must let air in and out sedated patient’s lungs according to trajectory airway pressures specified by clinician. Hand-tuned PID controllers similar variants have comprised industry standard decades, yet can behave poorly over- or under-shooting their target oscillating rapidly. data-driven machine learning approach: First, we train simulator based on data...
Many laboratories use two-photon microscopy through commercial suppliers, or homemade designs of considerable complexity. The integrated nature these systems complicates customization, troubleshooting as well grasping the principles microscopy. Here, we present "Twinkle": a microscope for Two-photon Imaging in Neuroscience, and Kit Learning Education. It is fully open, high-performance cost-effective research teaching without any custom parts beyond what can be fabricated university machine...
We consider the problem of controlling an invasive mechanical ventilator for pressure-controlled ventilation: a controller must let air in and out sedated patient's lungs according to trajectory airway pressures specified by clinician. Hand-tuned PID controllers similar variants have comprised industry standard decades, yet can behave poorly over- or under-shooting their target oscillating rapidly. data-driven machine learning approach: First, we train simulator based on data collect from...
ABSTRACT Background Multi-electrode arrays (MEAs) allow non-invasive multiunit recording in-vitro from cultured neuronal networks. For sufficient growth and adhesion on such MEAs, substrate preparation is required. Plating of dissociated neurons a uniformly prepared MEA’s surface results in the formation spatially extended random networks with substantial inter-sample variability. Such cultures are not optimally suited to study relationship between defined structure dynamics To overcome...