A5052467575- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Cardiac Arrest and Resuscitation
- Neonatal and fetal brain pathology
- Tracheal and airway disorders
- Cardiovascular Issues in Pregnancy
- 3D Printing in Biomedical Research
- Cardiovascular and Diving-Related Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Advanced MRI Techniques and Applications
- Intensive Care Unit Cognitive Disorders
- Ultrasound in Clinical Applications
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Anesthesia and Neurotoxicity Research
- Pregnancy and preeclampsia studies
- Disaster Response and Management
Cleveland Clinic
2018-2024
Riley Hospital for Children
2023
Indiana University – Purdue University Indianapolis
2022-2023
Cleveland Clinic Lerner College of Medicine
2018-2022
University of Miami
2016-2019
Batchelor Institute of Indigenous Tertiary Education
2017
Children’s Institute
2016
King Hussein Cancer Center
2011
Mesenchymal stem cells (MSC) improve alveolar and vascular structures in experimental models of bronchopulmonary dysplasia (BPD). Female MSC secrete more anti-inflammatory pro-angiogenic factors as compared to male MSC. Whether the therapeutic efficacy attenuating lung injury an model BPD is influenced by sex donor or recipient unknown. Here we tested hypothesis that female would have greater regenerative properties than this benefit be evident males.To determine whether intra-tracheal (IT)...
Mesenchymal stem cells (MSCs) attenuate lung injury in experimental models of bronchopulmonary dysplasia (BPD). Stromal derived factor-1 (SDF-1), a chemokine secreted by MSCs, modulates angiogenesis and cell recruitment. Here we tested the hypothesis that SDF-1 mediates MSC protective effects BPD modulating angiogenesis. was knocked down MSCs using lentiviral vectors carrying anti-SDF-1 short hairpin RNA (MSC-SDF KD). Non-silencing used as control (MSC-NS control). Newborn rats exposed to...
Mechanical ventilators are safety-critical devices that help patients breathe, commonly found in hospital intensive care units (ICUs)-yet, the high costs and proprietary nature of commercial inhibit their use as an educational research platform. We present a fully open ventilator device-The People's Ventilator: PVP1-with complete hardware software documentation including detailed build instructions DIY cost $1,700 USD. validate PVP1 against both key performance criteria specified U.S. Food...
Objectives: Transposition of the great arteries is most common cyanotic congenital heart defect. Surgical correction usually occurs in first week life; presence restrictive interatrial communication and severe hypoxemia warrants urgent intervention with balloon atrial septostomy medical stabilization prior to surgery. The main objective this study compare characteristics, outcomes, mortality risks patients transposition who underwent during their hospitalization versus have not undergone...
Soluble endoglin (sENG) is increased in the amniotic fluid of women with preeclampsia and chorioamnionitis. Preterm infants born to these disorders have an risk aberrant lung development. Whether this secondary elevated sENG levels unclear. The objective study was determine whether intrauterine exposure adenovirus overexpressing impairs neonatal angiogenesis by modulating endothelial nitric oxide synthase (eNOS) signaling. Pregnant Sprague-Dawley rats were randomly assigned receive...
The rapidly evolving COVID-19 pandemic has led to increased use of critical care resources, particularly mechanical ventilators. Amidst growing concerns that the health system could face a shortage ventilators in future, there is need for an affordable, simple, easy use, emergency stockpile ventilator.
The use of inhaled nitric oxide (iNO) in +late preterm and term infants with pulmonary hypertension is Food Drug Administration (FDA) approved has improved outcomes survival. iNO not FDA for previous studies show no mortality benefit. objectives were 1) to determine the usage among neonates <35 weeks before after 2010 National Institutes Health consensus statement 2) evaluate characteristics who received iNO.This a population-based cross-sectional study. Billing procedure codes used usage....
The syndrome of isosexual precocious puberty associated with primary malignant hepatic tumors is rare. All previously reported cases in the literature are old and prognosis was grim. We present case a 15-month-old Asian male baby who presented hepatoblastoma. Serum concentrations alpha-fetoprotein free testosterone were elevated, as beta human chorionic gonadotropin hormone. He treated six courses chemotherapy underwent surgery. His surface markers well level returned to normal during...
Bronchopulmonary dysplasia (BPD) is characterized by alveolar simplification and disordered angiogenesis. Stromal derived factor-1 (SDF-1) a chemokine which modulates cell migration, proliferation, Here we tested the hypothesis that intra-tracheal (IT) administration of naked plasmid DNA expressing SDF-1 would attenuate neonatal hyperoxia-induced lung injury in an experimental model BPD, promoting angiogenesis.Newborn Sprague-Dawley rat pups (n = 18-20/group) exposed to room air (RA) or...
The aim of the study is to identify rates and trends various procedures performed on newborns.
Bronchopulmonary dysplasia (BPD) is a heterogeneous disease that poses challenge when ventilating premature infants. The purpose of this study was to determine how inspiratory pressure rise time (IRT), different ventilators, and their software updates affect the balance ventilation among 2 lung units.A passive dual-chamber model constructed using IngMar ASL5000 approximate moderate BPD. One chamber had short constant, other long constant. Three ventilators were used provide control...
Despite the improving understanding of how lung mechanics and tidal volume requirements evolve during evolution bronchopulmonary dysplasia (BPD), clinical management continues to be heterogeneous inconsistent at many institutions. Recent reports have examined use high tidal-volume low respiratory rate strategies in these patients once disease has been well established help facilitate their eventual extubation improve long-term neurodevelopmental outcomes. In this retrospective observational...
The prevalence, morbidity, and mortality associated with Ebstein anomaly (EA) remains poorly characterized in neonates. EA is a rare form of congenital heart disease (CHD) significant heterogeneity.To determine the recent, 2000-2018, mortality, outcomes, healthcare utilization infants admitted at ≤28 days life comparison to other critical defects (CCHD) United States using national data set.The National Inpatient Sample (NIS) from Healthcare Cost Utilization Project (HCUP) was queried for...