A5057947661- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Connective Tissue Growth Factor Research
- Pulmonary Hypertension Research and Treatments
- Cardiac and Coronary Surgery Techniques
- Respiratory Support and Mechanisms
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Inflammasome and immune disorders
- Connective tissue disorders research
- Cardiac Ischemia and Reperfusion
- Neonatal Health and Biochemistry
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Mechanical Circulatory Support Devices
- Extracellular vesicles in disease
- TGF-β signaling in diseases
- Kawasaki Disease and Coronary Complications
- Thyroid Cancer Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- HER2/EGFR in Cancer Research
- Pregnancy and preeclampsia studies
- Heart Rate Variability and Autonomic Control
- Congenital Heart Disease Studies
Nanjing University
2009-2025
Peking University First Hospital
2016-2025
Peking University
2016-2025
University of Miami
2015-2024
Wenzhou Central Hospital
2024
Children’s Institute
2016-2024
Jackson Health System
2024
Inner Mongolia University
2024
University of Miami Hospital
2024
Palmetto General Hospital
2020-2024
Approximately 20-25% of traumatic brain injury (TBI) subjects develop acute lung (ALI), but the pathomechanisms TBI-induced ALI remain poorly defined. Our previous work has shown that inflammasome plays a critical role in secondary pathophysiology and proteins are released extracellular vesicles (EV) after TBI. Here we investigated whether EV-mediated signaling contributed to etiology ALI. C57/BL6 male mice were subjected controlled cortical impact (CCI), brains lungs examined for activation...
Mesenchymal stem cells (MSC) improve alveolar and vascular structures in experimental models of bronchopulmonary dysplasia (BPD). Female MSC secrete more anti-inflammatory pro-angiogenic factors as compared to male MSC. Whether the therapeutic efficacy attenuating lung injury an model BPD is influenced by sex donor or recipient unknown. Here we tested hypothesis that female would have greater regenerative properties than this benefit be evident males.To determine whether intra-tracheal (IT)...
Purpose: To compare the efficacy of four different ultrasound-based risk-stratification systems in assessing malignancy risk thyroid nodules Chinese population. Methods: We retrospectively reviewed digital ultrasound images 1568 patients (1612 nodules) who underwent surgery our hospital between January 2012 and December 2017. All were pathologically identified as malignant or benign. evaluated following characteristics: size, location, composition, echogenicity, shape, margins, calcification...
Abstract Mesenchymal stem cell (MSC) extracellular vesicles (EVs) have beneficial effects in preclinical bronchopulmonary dysplasia and pulmonary hypertension (BPD-PH) models. The optimal source, dosing, route, duration of are however unknown. objectives this study were to (a) compare the efficacy GMP-grade EVs obtained from Wharton’s Jelly MSCs (WJ-MSCs) bone marrow (BM-MSCs), (b) determine dosing route administration, (c) evaluate its long-term effects, (d) how MSC alter lung...
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The pathological hallmarks of bronchopulmonary dysplasia (BPD), one the most common long-term pulmonary complications associated with preterm birth, include arrested alveolarization, abnormal vascular growth, and variable interstitial fibrosis. Severe BPD is often complicated by hypertension characterized excessive remodeling right ventricular hypertrophy that significantly contributes to mortality morbidity these infants. Connective tissue growth factor (CTGF) a multifunctional protein...
Hyperoxia plays a key role in the development of bronchopulmonary dysplasia (BPD), chronic lung disease preterm infants. Infants with BPD often have brain injury that leads to long-term neurodevelopmental impairment, but underlying mechanisms control BPD-induced impairment remain unclear. Our previous studies shown hyperoxia-induced rodents is associated inflammasome activation. Here, we tested hypothesis and mediated by activation, inhibition caspase-1, component inflammasome, attenuates...
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The pathological hallmarks of bronchopulmonary dysplasia (BPD), a chronic lung disease premature infants, include inflammation, arrested alveolarization, and dysregulated angiogenesis. Severe BPD is often complicated by pulmonary hypertension (PH) that significantly increases morbidity mortality. Glycogen synthase kinase (GSK)-3β plays pivotal role in embryonic development, cell proliferation survival, inflammation modulating multiple signaling pathways, particularly the nuclear...
Abstract Hyperoxia-induced lung injury plays a key role in the development of bronchopulmonary dysplasia (BPD), characterized by inflammatory and impaired preterm infants. Although BPD is predictor poor neurodevelopmental outcomes, currently it uncertain how contributes to brain Extracellular vesicles (EVs) are heterogeneous group cell-derived membranous structures that regulate intercellular inter-organ communications. Gasdermin D (GSDMD) has emerged as executor inflammasome-mediated cell...
Bronchopulmonary dysplasia (BPD) is the most common and serious chronic lung disease of preterm infants. The development pulmonary hypertension (PH) significantly increases mortality morbidity this disease. β-Catenin signaling plays an important role in tissue remodeling. Aberrant β-catenin associated with clinical experiment models BPD. To test hypothesis that inhibition beneficial promoting alveolar vascular preventing PH experimental BPD, we examined effects ICG001, a newly developed...
Abstract Preterm infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH) have accelerated lung aging poor long-term outcomes. Klotho is an antiaging protein that modulates oxidative stress, angiogenesis fibrosis. Here we test the hypothesis decreased cord levels in preterm predict increased BPD–PH risk early supplementation prevents BPD-like phenotype PH rodents exposed to neonatal hyperoxia. In experiment 1, were measured blood of who enrolled a longitudinal cohort...
Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are among the most common morbidities affecting extremely premature infants who receive oxygen therapy. Many clinical studies indicate that BPD is associated with advanced ROP. However, mechanistic link between hyperoxia, BPD, ROP remains to be explored. Gasdermin D (GSDMD) a key executor inflammasome-induced pyroptosis inflammation. Inhibition GSDMD has been shown attenuate hyperoxia-induced brain injury in neonatal mice....
Abstract Background Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common morbidities affecting extremely premature infants and a leading cause severe vision impairment in children worldwide. Activations inflammasome cascade microglia have been implicated playing role development both ROP BPD. Apoptosis-associated speck-like protein containing caspase recruitment domain (ASC) pivotal assembly. Utilizing mouse models...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES