A5088488665- Bone Tissue Engineering Materials
- Tendon Structure and Treatment
- Silk-based biomaterials and applications
- Orthopedic Surgery and Rehabilitation
- Tissue Engineering and Regenerative Medicine
- Global Health and Surgery
- Organ Transplantation Techniques and Outcomes
- Facial Trauma and Fracture Management
- Organ and Tissue Transplantation Research
- Reconstructive Surgery and Microvascular Techniques
- Artificial Intelligence in Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital limb and hand anomalies
- Central Venous Catheters and Hemodialysis
- Reconstructive Facial Surgery Techniques
- Electrospun Nanofibers in Biomedical Applications
- Connective Tissue Growth Factor Research
- Mesenchymal stem cell research
- Surgical Simulation and Training
- Graphene and Nanomaterials Applications
- Vascular anomalies and interventions
- Organ Donation and Transplantation
- Knee injuries and reconstruction techniques
- Periodontal Regeneration and Treatments
- Congenital gastrointestinal and neural anomalies
University of Nottingham
2023-2024
Johns Hopkins Medicine
2021-2023
Johns Hopkins University
2021-2023
SUNY Upstate Medical University
2023
University of California, Los Angeles
2015-2019
Los Angeles Medical Center
2019
Harvard University
2009-2012
Massachusetts General Hospital
2009-2012
Massachusetts Institute of Technology
2009
Harvard–MIT Division of Health Sciences and Technology
2009
This study instituted a unique approach to bone tissue engineering by combining effects of mechanical stimulation in the form fluid shear stresses and presence bone-like extracellular matrix (ECM) on osteodifferentiation. Rat marrow stromal cells (MSCs) harvested from were cultured titanium (Ti) fiber mesh discs for 12 days flow perfusion system generate constructs containing ECM. To observe osteodifferentiation deposition, these decellularized plain Ti meshes seeded with MSCs (Ti/ECM Ti,...
Abstract In this study, we cultured marrow stromal cells on titanium fiber meshes in a flow perfusion bioreactor and examined the effect of altering scaffold mesh size cell behavior an effort to develop bone tissue construct composed scaffold, osteogenic cells, extracellular matrix. Scaffolds differing size, that is, distance between fibers, were created by diameter fibers (20 or 40 μm) while maintaining constant porosity. These scaffolds had porosity 80% sizes 65 μm (20‐μm fibers) 119...
Abstract Background and Objective Suture repair of Achilles tendon rupture can cause infection, inflammation scarring, while prolonged immobilization promotes adhesions to surrounding tissues joint stiffness. Early mobilization reduce complications provided the is strong enough resist re‐rupture. We have developed a biocompatible, photoactivated wrap from electrospun silk (ES) provide additional strength that could permit early mobilization, act as barrier adhesion formation. Study...
Vascularized composite allotransplantation (VCA) is a viable reconstructive option for complex tissue defects. Although grafts with large muscular component may be uniquely susceptible to ischemia-reperfusion (I/R) syndrome, the safe cold ischemia time in VCA has not been established. We investigated effects of on innate immune response and recipient survival murine orthotopic hindlimb transplantation model. Surprisingly, mice receiving exposed 6 h or longer storage demonstrated reduced...
Background: Intravenous immunoglobulin (IVIg) for Clostridioides difficile infection (CDI) no longer features in treatment guidelines. However, IVIg is still used by some clinicians severe or recurrent CDI (rCDI) cases. The main objective of this study was to investigate the efficacy and identify possible predictors disease resolution post administration patients with CDI. Methods: This retrospective observational cohort ≥2 years old hospitalised severe, relapsing, rCDI treated therapy...