The present study aimed to investigate the protective and therapeutic effects of caffeine on rotenone-induced rat model Parkinson's disease (PD). Rats were divided into control, PD induced by rotenone (1.5 mg/kg intraperitoneally (i.p.) for 45 days), protected group injected with (30 mg/kg, i.p.) days (during development model), treated after induction model. data revealed a state oxidative nitrosative stress in midbrain striatum animal as indicated from increased lipid peroxidation nitric...

Oxidized proteins as well modified by the lipid peroxidation product 4-hydroxy-2-nonenal (HNE) and glycation (AGE) have been shown to accumulate with aging in vivo during replicative senescence vitro. To better understand mechanisms which these damaged build up potentially affect cellular function of WI-38 fibroblasts, targeted modifications identified using a bidimensional gel electrophoresis-based proteomic approach coupled immunodetection HNE-, AGE-modified carbonylated proteins....

Protein damage mediated by oxidation, protein adducts formation with advanced glycated end products and of lipid peroxidation, has been implicated during aging age-related diseases, such as neurodegenerative diseases. Increased modification also described upon replicative senescence human fibroblasts, a valid model for studying in vitro . However, the mechanisms which these modified proteins could impact on development senescent phenotype pathogenesis diseases remain elusive. In this study,...

One new naturally isoflavone compound, 5,7,2',3',4' penta hydroxyl isoflavone-4'-O-β-glucopyranoside (1) was isolated from the aqueous methanol extract (AME) of Pulicaria undulata subsp. undulata, together with seven known compounds: kaempferol (2), 3-O-β-glucoside (3), quercetin (4), (5), 3-O-β-galactoside (6), 3,7-di OCH3 (7), and caffeic acid (8). Their structures were established through chemical (acid hydrolysis) spectral analysis (UV, NMR, ESIM). The AME some compounds evaluated as...

To investigate the prophylactic efficacy of gut microbiota-based treatments on nonalcoholic steatohepatitis (NASH) management via modulation Hippo signaling pathway-related genes (YAP1, LATS1 and NF2), their epigenetic regulators (miR-1205 lncRNA SRD5A3-AS1) retrieved from in-silico data analysis.

The aim of the present research was to evaluate anti-inflammatory activity pumpkin seed oils (PSOs) an Egyptian and European variety, in a rat model adjuvant arthritis. Edema thickness, plasma tumor necrosis factor-α (TNF-α) erythrocyte sedimentation rate (ESR) were determined as inflammatory biomarkers while malondialdehyde (MDA) total antioxidant capacity (TAC) assessed indicative oxidative stress. Chromosomal aberration, sperm shape abnormalities, DNA fragmentations are cytogenetic...

To date few reports have pointed out the role of circulating miRNAs in discriminating metastatic liver tumors from primary hepatocellular (HCC) tumors. Such discrimination will significant therapeutic and prognostic implications. The purpose this study was to evaluate potential value a panel HCC-related (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 miR-1246) as noninvasive biomarkers for HCC liver.The expression level selected quantified by quantitative...

The objective of the present study was to evaluate cardiovascular protective effect Egyptian and European umpkin seed oil (PSO) in hypercholesterolemic rats. Tocopherols, fatty acids (FAs) unsaponifiable matter (UNSAP) were assessed both oils. results showed that α-tocopherol 108 273, γ-tocopherol 3.95 0 d-tocopherol 1.58 mg·100 g-1 European, respectively. GLC analysis FAs revealed presence linoleic acid as major Feeding a diet produced significant increase plasma total cholesterol (T-Ch),...

An accumulating body of evidence supports the role autophagy in pathophysiology T2DM. Also, abnormal endoplasmic reticulum (ER) stress response that has been implicated as a cause insulin resistance (IR) could also be affected by autophagic status β-cells. The present study was designed to investigate whether is regulated T2DM well modulatory effect ER inhibitor 4-phenylbutyric acid (4-PBA) and inducer rapamycin (Rapa) on diabetic using type 2 animal model with IR. Treatment rats either...

Background: 4-Aminoquinoline derivatives possess various potential biological properties.The introduction of additional piperazine heterocyclic pharmacophoric moiety tends to haveprofound impact in increasing the activity. The present work was undertaken investigate thein-vitro and in-vivo anti-inflammatory activity as well peripheral central analgesicactivities compound 1-(4-(7-chloroquinoline-4-yl)piperazin-1-yl)-2-(4-phenylpiperazin-1-yl)ethanone (5) experimental models. Methods:...

Abstract The main objective of this study was to investigate the potential protective effect ursodeoxycholic acid ( UDCA ) on fructose/streptozotocin‐induced diabetic cataract in rats. model DM induced through administration 10% fructose drinking water for 2 weeks followed by streptozotocin injection intraperitoneal ). One week later, hyperglycemia assisted and animals were treated with either as local eye drops (0.5% solution, four times/day) or orally (100 mg/kg b.w.). Cataract formation...

The present study was undertaken to evaluate the chemopreventive activity of myrtenal, a natural monoterpene, against bladder carcinoma in rats induced with N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) and promoted γ-ionizing radiation (γ-IRR) as well assess involvement inflammation, apoptosis oxidative damage tumor development. Histopathological examination rat revealed presence noninvasive papillary transitional cell (Grade 2) sections from BBN group indicating credibility applied...

Aspergillus unguis SPMD-EGY (A. unguis) and sp. 2C1-EGY (Aspergillus sp.) were isolated from the soft corals Sinularia Lobophyton sp in Hurghada coast, Red Sea, Egypt. One strain many compounds (OSMAC) was applied to trigger fungal silent biosynthetic genes. The results revealed that A. static filtrate extracts (St F) of all tested media exhibited highest antimicrobial activity (inhibition zones 18.5-30.5 mm) against S. aureus, P. aeruginosa, C. albicans. shake cell A C α-glucosidase...

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