A5071324328- Wound Healing and Treatments
- Pressure Ulcer Prevention and Management
- Autoimmune and Inflammatory Disorders
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Diabetic Foot Ulcer Assessment and Management
- Diagnosis and Treatment of Venous Diseases
- Eosinophilic Disorders and Syndromes
- Skin Diseases and Diabetes
- Cutaneous lymphoproliferative disorders research
- Plasma Applications and Diagnostics
- Oral Health Pathology and Treatment
- Dermatological diseases and infestations
- Medicine and Dermatology Studies History
- Venous Thromboembolism Diagnosis and Management
- Hidradenitis Suppurativa and Treatments
- Nail Diseases and Treatments
- Lymphatic System and Diseases
- Streptococcal Infections and Treatments
- Artificial Intelligence in Healthcare and Education
- Parkinson's Disease and Spinal Disorders
- Burn Injury Management and Outcomes
- Vascular Tumors and Angiosarcomas
- Hair Growth and Disorders
- Spectroscopy Techniques in Biomedical and Chemical Research
Essen University Hospital
2017-2024
University of Duisburg-Essen
2017-2024
Ruhrlandklinik
2024
Bristol-Myers Squibb (Switzerland)
2023
Boehringer Ingelheim (Canada)
2023
Leo Pharma (Australia)
2023
Novartis (France)
2023
Roche (Switzerland)
2023
Janssen (Switzerland)
2023
AstraZeneca (Poland)
2023
Bacteria in wounds can lead to stagnation of wound healing as well local or even systemic infections up potentially lethal sepsis. Consequently, the bacterial load should be reduced part treatment. Therefore, efficacy simple mechanical debridement investigated terms reducing colonisation.
Abstract Bacterial colonisation in wounds delays healing, mandating regular bacterial removal through cleaning and debridement. Real‐time monitoring of the efficacy mechanical debridement has recently become possible fluorescence imaging. Red fluorescence, endogenously produced during metabolism, indicates regions contaminated with live bacteria (>10 4 CFU/g). In this prospective study, conventional photos were taken 25 venous leg ulcers before after debridement, without use antiseptics....
Summary Background Cold atmospheric plasma (CAP) has been used successfully for wound treatment, with thrice weekly treatment intervals. In this study, we wished to investigate whether comparably beneficial results can be achieved even once CAP treatment. Patients and methods randomized clinical pilot study (RCT) patients therapy‐refractory chronic wounds were examined over a maximum of twelve weeks. Groups 1 2 treated twice week, respectively. in Group 3 received placebo therapy week....
Abstract Pyoderma gangrenosum (PG) is a non‐infectious, neutrophilic dermatosis that was difficult to diagnose in clinical practice. Today, the PARACELSUS score validated tool for diagnostics. Based on this score, patients with clearly diagnosed PG were examined regard predilection sites. In retrospective study, data of from University Hospitals Essen and Erlangen analysed whom diagnosis could be confirmed using score. A total 170 patients, 49 men (29%) 121 women (71%) an average age at...
Introduction: Automation bias poses a significant challenge to the effectiveness of Clinical Decision Support Systems (CDSS), potentially compromising diagnostic accuracy. Previous research highlights trust, self-confidence, and task difficulty as key determinants. With increasing availability AI-enabled CDSS, automation attains new attention. This study therefore aims identify factors influencing in task. Methods: A quantitative intervention with participants from different backgrounds (n =...
Diabetic foot ulcer (DFU) is a chronic wound and common diabetic complication as 2% - 6% of patients witness the onset thereof. The DFU can lead to severe health threats such infection lower leg amputations, Coordination interdisciplinary care requires well-written but time-consuming documentation. Artificial intelligence (AI) systems lend themselves be tested extract information from images, e.g. maceration, fill A convolutional neural network was therefore trained on 326 augmented images...
Abstract Visual clinical diagnosis of dermatoses in people color (PoC) is a considerable challenge daily practice and potential cause misdiagnosis this patient cohort. The study aimed to determine the difference visual diagnostic skills dermatologists practicing Germany patients with light skin (Ls) (SoC) identify need for further education. From April June 2023, German were invited complete an online survey 24 photographs depicting 12 diseases on both Ls SoC. study’s primary outcomes number...
Patients with leg ulcers often have severe edema of the lower extremities, which should be treated as part a successful wound treatment. Today in Germany necessary compression therapies are performed very error-prone and time-consuming short-stretch bandages only. Multicomponent systems, adaptive ulcer stocking systems newer, much less treatment options. In addition to lacking knowledge, fears high costs also mentioned reasons for lack prescription these systems. It was therefore our aim...
Abstract Background Pyoderma gangrenosum (PG) is a rare ulcerative skin condition with no current standardized outcomes or outcome measures. With rich investigational therapeutic pipeline, standardization of and improvement data quality interpretability will promote the appropriate consistent evaluation potential new therapies. Core sets (COS) are agreed, that represent minimum should be measured reported in all clinical trials specific condition. Objectives To identify reach consensus on...
Pyoderma gangrenosum (PG) is rare neutrophil skin disease causing painful, progressively enlarging ulcers. Among the treatment options, intravenous immunoglobulin (IVIG) a therapy of first choice for paraneoplastic PG. Otherwise, it used in therapy-refractory courses. To assess efficacy and safety IVIG patients with A retrospective chart review five dermatologic wound centres Germany was performed. Overall, 81 were included. as adjunct (methyl-) prednisolone and/or steroid sparing 77 (95.1%)...
Chronic wounds are ulcerations of the skin that fail to heal because an underlying condition such as diabetes mellitus or venous insufficiency. The timely identification this is crucial for healing. However, requires expert knowledge unavailable in some care situations. Here, artificial intelligence technology may support clinicians. In study, we explore performance a deep convolutional neural network classify diabetic foot and leg ulcers using wound images. We trained on 863 cropped Using...
Zusammenfassung Hintergrund Psoriasisplaques an den Unterschenkeln zeigen sich oftmals besonders therapierefraktär. Eine Kompressionstherapie könnte dieser Lokalisation möglicherweise eine sinnvolle ergänzende Therapiemaßnahme darstellen. Jedoch bestehen oft Bedenken, dass ein Köbner-Phänomen zu einer Verschlechterung des Hautbefundes führen könnte. Daher sollten in Studie die Effekte auf bei gleichzeitig bestehenden Ödemen untersucht werden. Patienten und Methoden Es erfolgte...
Wound infections are a major problem worldwide, both for the healthcare system and patients affected. Currently available diagnostic methods to determine responsible germs time-consuming costly. mostly caused by various bacteria, which in turn produce volatile organic compounds. From clinical experience, we know that depending on bacteria involved, specific odor impression can be expected. For this reason, hypothesized electronic noses, i.e., non-invasive sensors detection of compounds,...
Zusammenfassung Hintergrund Wöchentlich dreimalige Anwendung kalten atmosphärischen Plasmas (KAP) wurde bereits erfolgreich zur Wundbehandlung eingesetzt. Jetzt sollte untersucht werden, ob mit nur einmal wöchentlicher Behandlung vergleichbar gute Ergebnisse erzielt werden können. Patienten und Methodik In dieser randomisierten klinischen Pilotstudie (RCT) wurden therapierefraktären chronischen Wunden über maximal zwölf Wochen 1 x/Woche (Gruppe 1) oder 3 2) KAP behandelt. der Gruppe...
Venous leg ulcers and diabetic foot are the most common chronic wounds. Their prevalence has been increasing significantly over last years, consuming scarce care resources. This study aimed to explore performance of detection classification algorithms for these types wounds in images. To this end, YoloV5 family pre-trained models were applied 885 images containing at least one two wound types. The YoloV5m6 model provided highest precision (0.942) a high recall value (0.837). Its mAP_0.5:0.95...
For artificial intelligence (AI) based systems to become clinically relevant, they must perform well. Machine Learning (ML) AI require a large amount of labelled training data achieve this level. In cases shortage such amounts, Generative Adversarial Networks (GAN) are standard tool for synthesising images that can be used augment the set. We investigated quality synthetic wound regarding two aspects: (i) improvement wound-type classification by Convolutional Neural Network (CNN) and (ii)...
For observational studies, which are relevant especially for chronic conditions like wounds, the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) offers a standardized database schema. In this study an ETL process transition of wound related data was developed. After understanding in general and mapping codes to concepts available OMOP, implemented. first step, generic algorithm convert csv format implemented Java. The resulting file then processed within KNIME be...